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immunity

Open Access | Sterile protective immunity to malaria is associated with a panel of novel P. falciparum antigens

September 15, 2011 - 15:21 -- Patrick Sampao
Author(s): 
Angela Trieu, Matthew A. Kayala, Chad Burk, Douglas M. Molina, Daniel A. Freilich, Thomas L. Richie, Pierre Baldi, Philip L. Felgner and Denise L. Doolan
Reference: 
mcp.M111.007948.

These results have important implications for vaccine development, suggesting that an efficacious malaria vaccine should be multivalent and targeted at a select panel of key antigens, many of which have not been previously characterized.

Open Access | Extreme CD8 T Cell Requirements for Anti-Malarial Liver-Stage Immunity following Immunization with Radiation Attenuated Sporozoites

July 19, 2010 - 08:42 -- Kabogo Ndegwa
Author(s): 
Nathan W. Schmidt, Noah S. Butler, Vladimir P. Badovinac, John T. Harty
Reference: 
PLoS Pathog 6(7): e1000998

Radiation-attenuated Plasmodium sporozoites (RAS) are the only vaccine shown to induce sterilizing protection against malaria in both humans and rodents.

Medical Treatment: 

Minimal Role for the Circumsporozoite Protein in the Induction of Sterile Immunity by Vaccination with Live Rodent Malaria Sporozoites

April 19, 2010 - 14:17 -- Patrick Sampao
Author(s): 
Marjorie M., Rita T., et al.
Reference: 
Infection and Immunity, Vol. 78, No. 5 p. 2182-2188, May 2010

Here, we have employed transgenic Plasmodium berghei parasites in which the endogenous CSP was replaced by that of Plasmodium yoelii, another rodent malaria species, to assess the role of CSP in the sterile protection induced by the Spz-plus-CQ protocol.

Person: 

Open Access | A prospective analysis of the Ab response to Plasmodium falciparum before and after a malaria season by protein microarray

April 15, 2010 - 12:11 -- Kabogo Ndegwa
Author(s): 
Peter D. Crompton, Matthew A. Kayala, Susan K. Pierce,.et al
Reference: 
PNAS 2010 107 (15) 6958-6963

This approach, if validated in larger studies and in other epidemiological settings, could prove to be a useful strategy for better understanding fundamental properties of the human immune response to Pf and for identifying previously undescribed vaccine targets.

Technology: 

Small variant surface antigens and Plasmodium evasion of immunity

April 7, 2010 - 13:29 -- Patrick Sampao
Tags: 
Author(s): 
Jemmely, Noelle Yvonne1; Niang, Makhtar; Preiser, Peter Rainer
Reference: 
Future Microbiology, Volume 5, Number 4, April 2010 , pp. 663-682(20)

 

In this article, we highlight our current understanding of these variant antigens and provide insights on the mechanisms developed by malaria parasites to effectively avoid the host immune response and establish chronic infection.

Review: Erythrocyte invasion and functionally inhibitory antibodies in Plasmodium falciparum malaria

March 31, 2010 - 09:46 -- Patrick Sampao
Author(s): 
Kristina E.M. Persson
Reference: 
Acta Tropica, Volume 114, Issue 3, June 2010, Pages 138-143

This review gives an overview of the erythrocyte invasion process, which has been described to include several different antigens.

Parasitaemia levels in Plasmodium chabaudi infected-mice modify IFN-γ and IL-10 expression after a homologous or heterologous challenge

March 17, 2010 - 10:28 -- Ingeborg van Schayk
Author(s): 
M. Aguilar-Medina, R. Ramos-Payan, E. Arambula-Meraz, L. Sanchez-Torres, L. Favila-Castillo
Reference: 
Parasite Immunology Volume 32 Issue 4, Pages 267 - 274

CB6F1 mice infected with the nonlethal Plasmodium chabaudi chabaudi AS suffer parasitaemia levels up to 40% (full parasitaemia, FP) and develop both homologous and heterologous (against the lethal Plasmodium yoelii 17XL) protective immunity.

Report: A Peroxidase/Dual Oxidase System Modulates Midgut Epithelial Immunity in Anopheles gambiae

March 17, 2010 - 08:50 -- Ingeborg van Schayk
Author(s): 
Sanjeev Kumar, Alvaro Molina-Cruz, Lalita Gupta, Janneth Rodrigues, Carolina Barillas-Mury
Reference: 
Science DOI: 10.1126/science.1184008

We show that a peroxidase, secreted by the Anopheles gambiae midgut, and dual oxidase form a dityrosine network that decreases gut permeability to immune elicitors.

Immunology: Parasitaemia levels in Plasmodium chabaudi infected-mice modify IFN-gamma and IL-10 expression after a homologous or heterologous challenge

March 11, 2010 - 13:18 -- Patrick Sampao
Author(s): 
M. Aguilar-Medina, R. Ramos-Payan, E. Arambula-Meraz, L. Sanchez-Torres, L. Favila-Castillo.
Reference: 
Parasite Immunology,Volume 32, Issue 4, April 2010, Pages: 267-274

CB6F1 mice infected with the nonlethal Plasmodium chabaudi chabaudi AS suffer parasitaemia levels up to 40% (full parasitaemia, FP) and develop both homologous and heterologous (against the lethal Plasmodium yoelii 17XL) protective immunity.

Person: 

Age-dependent association between IgG2 and IgG3 subclasses to Pf332-C231 antigen and protection from malaria and induction of protective antibodies by sub-patent malaria infections, in Daraweesh

February 4, 2010 - 15:38 -- Kabogo Ndegwa
Author(s): 
Hayder A. Giha, Amre Nasr, Nnaemeka C. Iriemenam, Halima A. Balogun, David Arnot, Thor G. Theanderf, Marita Troye-Blomberg, Klavs Berzins and Gehad ElGhazali
Reference: 
Vaccine, Volume 28, Issue 7, 17 February 2010, Pages 1732-1739

In conclusion, this report suggests a protective effect for IgG subclasses to Pf332-C231 antigen against malaria.

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