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falciparum malaria

Open Access | Clindamycin plus quinine for treating uncomplicated falciparum malaria: a systematic review and meta-analysis

January 5, 2012 - 07:05 -- Kabogo Ndegwa
Author(s): 
Obonyo CO, Juma EA
Reference: 
Malaria Journal 2012, 11:2 (4 January 2012)

MalariaWorldThe evidence on the efficacy of clindamycin plus quinine as an alternative treatment for uncomplicated malaria is inconclusive.

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Open Access | Similar efficacy and safety of artemether-lumefantrine (Coartem(R)) in African infants and children with uncomplicated falciparum malaria across different body weight ranges

December 20, 2011 - 09:07 -- Kabogo Ndegwa
Author(s): 
Bassat Q, Gonzalez R, Machevo S, Nahum A, Lyimo J, Maiga H, Martensson A, Bashraheil M, Ouma P, Ubben D, Walter V, Nwaiwu O, Kipkeu C, Lefevre G, Ogutu B, Menendez C
Reference: 
Malaria Journal 2011, 10:369 (16 December 2011)

MalariaWorldEfficacy of AL in uncomplicated falciparum malaria is similar across body weight dosing groups as currently recommended in the label with no clinically relevant differences in safety or tolerability.

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Deletion of the APOBEC3B gene strongly impacts susceptibility to falciparum malaria

December 16, 2011 - 13:53 -- Patrick Sampao
Author(s): 
Pankaj Jha, Swapnil Sinha, Saman Habib, et al.
Reference: 
Infection, Genetics and Evolution, Volume 12, Issue 1, January 2012, Pages 142-148

MalariaWorldOur study also presents a case for malaria as a positive selection force for the APOBEC3B insertion and suggests a major role for this gene in innate immunity against malaria.

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Efficacy of chloroquine plus primaquine treatment and pfcrt mutation in uncomplicated falciparum malaria patients in Rangamati, Bangladesh

November 25, 2011 - 14:51 -- Patrick Sampao
Author(s): 
Atsuko Kawai, Namie Arita, Yasuyo Matsumoto, Masato Kawabata, M. Stephen Chowdhury, Atsuko Saito-Ito
Reference: 
Parasitology International, Volume 60, Issue 4, December 2011, Pages 341-346

MalariaWorldOf the 38 patients, in total 15 patients (14/25 minority-indigenous and 1/13 Bengali patients) resulted in adequate clinical and parasitological response (ACPR).

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Open Access | Pharmacokinetics of Dihydroartemisinin and Piperaquine in Pregnant and Nonpregnant Women with Uncomplicated Falciparum Malaria

November 15, 2011 - 07:37 -- Kabogo Ndegwa
Author(s): 
Marcus J. Rijken, Rose McGready, Aung Phae Phyo, Niklas Lindegardh, Joel Tarning, Natthapon Laochan, Hla Hla Than, Oh Mu, Aye Kyi Win, Pratap Singhasivanon, Nicholas White, and François Nosten
Reference: 
Antimicrob. Agents Chemother. December 2011 vol. 55 no. 12 5500-5506

MalariaWorldDihydroartemisinin-piperaquine is a fixed-dose artemisinin-based combination treatment. Some antimalarials have altered pharmacokinetics in pregnancy.

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Open Access | Standardizing the measurement of parasite clearance in falciparum malaria: the parasite clearance estimator

November 15, 2011 - 07:21 -- Kabogo Ndegwa
Author(s): 
Flegg JA, Guerin PJ, White NJ, Stepniewska K
Reference: 
Malaria Journal 2011, 10:339 (10 November 2011)

MalariaWorldThe parasite clearance estimator provides a consistent, reliable and accurate method to estimate the lag phase and malaria parasite clearance rate.

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A Simple Dose Regimen of Artesunate and Amodiaquine Based on Arm Span- or Age Range for Childhood Falciparum Malaria: A Preliminary Evaluation

November 8, 2011 - 08:23 -- Kabogo Ndegwa
Author(s): 
Akintunde Sowunmi, Ibukun A. Akinrinola, Grace O. Gbotosho, Titilope M. Okuboyejo, and Christian T. Happi
Reference: 
J Trop Pediatr (2011)

MalariaWorldA dose regimen of artesunate and amodiaquine based on arm span- or age range (DRAAAS), derived from a study of 1674 children, was compared with standard dose regimen of the same drugs calculated according to body weight (SDRAA) in 68 malarious children.

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Distinct cytokine profiles define clinical immune response to falciparum malaria in regions of high or low disease transmission.

October 19, 2011 - 14:22 -- Patrick Sampao
Author(s): 
Sinha S, Qidwai T, Kanchan K, Jha GN, Anand P, Pati SS, Mohanty S, Mishra SK, Tyagi PK, Sharma SK, Awasthi S, Venkatesh V, Habib S.
Reference: 
Eur Cytokine Netw. 2010 Dec 1;21(4):232-40. Epub 2010 Nov 15.

MalariaWorldWe analyzed circulating levels of pro-inflammatory (TNF, IFN-γ, IL-12, IL-16) and anti-inflammatory (IL-4, IL-10, IL-13) cytokines in control and patient groups drawn from a P. falciparum-endemic and a non-endemic region of India.

Refractory Pancytopenia and Megaloblastic Anemia due to Falciparum Malaria

August 2, 2011 - 09:22 -- Kabogo Ndegwa
Author(s): 
Varun Aggarwal, Anu Maheshwari, Bimbadhar Rath, Praveen Kumar, and Srikanta Basu
Reference: 
J Trop Pediatr (2011) 57 (4): 283-285. doi: 10.1093/tropej/fmq090

Anemia is a common complication in malarial infection. Direct destruction and ineffective erythropoesis does not adequately explain the cause of anemia in malaria.

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Therapeutic Efficacies of Artemisinin-Based Combination Therapies in Nigerian Children with Uncomplicated Falciparum Malaria during Five Years of Adoption as First-Line Treatments

June 3, 2011 - 09:30 -- Patrick Sampao
Author(s): 
Grace O. Gbotosho, Akintunde Sowunmi, Christian T. Happi, and Titilope M. Okuboyejo
Reference: 
Am J Trop Med Hyg 2011 84:936-943

The therapeutic efficacies of 3-day regimens of artesunate-amodiaquine and artemether-lumefantrine during 5 years of adoption as first-line treatments were evaluated in 811 ≤ 12-year-old malarious children.

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