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falciparum malaria

Not Open Access | Population pharmacokinetics of halofantrine in healthy volunteers and patients with symptomatic falciparum malaria

October 16, 2012 - 16:45 -- Patrick Sampao
Author(s): 
Klein K, Aarons L, Ter Kuile FO, Nosten F, White NJ, Edstein MD, Teja-Isavadharm P.
Reference: 
J Pharm Pharmacol. 2012 Nov;64(11):1603-1613

MalariaWorldTo investigate the population pharmacokinetics of the antimalarial halofantrine (HF) in healthy volunteers and patients with symptomatic falciparum malaria.

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Reappraisal of the Efficacy of a Simplified Artesunate Regimen in Falciparum Malaria

August 1, 2012 - 14:37 -- Patrick Sampao
Author(s): 
Charles J. Woodrow and Walter R. J. Taylor
Reference: 
J Infect Dis. (2012) 206 (4): 619-621

MalariaWorld This apparent contradiction led us to examine key elements of the trial methodology in the context of established guidelines on the conduct and reporting of randomized controlled trials.

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Pharmacokinetics of Piperaquine in Pregnant Women in Sudan with Uncomplicated Plasmodium falciparum Malaria

July 4, 2012 - 13:12 -- Patrick Sampao
Author(s): 
Ishag Adam, Joel Tarning, Niklas Lindegardh, Hyder Mahgoub, Rose McGready and François Nosten
Reference: 
Am J Trop Med Hyg 2012 87:35-40

MalariaWorldThe overall pharmacokinetic properties of piperaquine in this study were consistent with previously published reports in non-pregnant patients.

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Efficacy of artemether-lumefantrine, the nationally-recommended artemisinin combination for the treatment of uncomplicated falciparum malaria, in southern Laos

June 13, 2012 - 14:59 -- Patrick Sampao
Author(s): 
Mayxay M, Khanthavong M, Chanthongthip O, Imwong M, Pongvongsa T, Hongvanthong B, Phompida S, Vanisaveth V, White NJ, Newton PN
Reference: 
Malaria Journal 2012, 11:184 (8 June 2012)

MalariaWorldOf 630 patients with P. falciparum enrolled in the trial of thiamin treatment, 549 (87%, 357 children [less than or equal to]15 years and 192 adults) were included in this study.

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NOT Open Access | Antimalarial Efficacy of a Quantified Extract of Nauclea pobeguinii Stem Bark in Human Adult Volunteers with Diagnosed Uncomplicated falciparum Malaria. Part 2: A Clinical Phase IIB Trial

June 1, 2012 - 08:42 -- Patrick Sampao
Author(s): 
Kahunu Mesia, Lutete Tona, Arnold J. Vlietinck, et al.
Reference: 
Planta Med -0031-1298488

MalariaWorldThe study showed a significant decreased parasitaemia in patients treated with PR 29 CT1 and artesunate-amodiaquine with adequate clinical parasitological responses (APCR) at day 14 of 87.9 and 96.9 %, respectively.

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Open Access | Case Report: Haemolytic anaemia in an HIV-infected patient with severe falciparum malaria after treatment with oral artemether-lumefantrine

March 30, 2012 - 13:24 -- Patrick Sampao
Author(s): 
Corpolongo A, De Nardo P, Ghirga P, Gentilotti E, Bellagamba R, Tommasi C, Paglia M, Nicastri E, Narciso P
Reference: 
Malaria Journal 2012, 11:91 (27 March 2012)

MalariaWorldThis paper describes the case of an HIV-infected patient with severe falciparum malaria who was diagnosed with haemolytic anaemia after treatment with oral artemether-lumefantrine.

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Uncommon Manifestation of a Mixed-Species Malaria Infection: Cryptic Falciparum Malaria in a Traveler With Successfully Treated Tertian Malaria

March 15, 2012 - 07:04 -- Kabogo Ndegwa
Author(s): 
Nikolai Menner, Matthias Borchert, Sebastian Dieckmann, Ralf Ignatius and Frank P. Mockenhaupt
Reference: 
Journal of Travel Medicine, Volume 19, Issue 2, pages 133–135, March/April 2012

MalariaWorldWe report a case of falciparum malaria in a traveler 9 days after successful treatment of ovale malaria.

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Short Report: Successful Oral Therapy for Severe Falciparum Malaria: The World Health Organization Criteria Revisited

March 9, 2012 - 13:34 -- Patrick Sampao
Author(s): 
Eran Kopel, Enbal Marhoom, Yechezkel Sidi and Eli Schwartz
Reference: 
Am J Trop Med Hyg 2012 86:409-411

MalariaWorldWe report a successful treatment of severe falciparum malaria in a non-immune adult patient with 30% parasitemia treated with the 6-dose oral regimen of artemether plus lumefantrine combination therapy alone.

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Population Pharmacokinetics and Pharmacodynamics of Piperaquine in Children With Uncomplicated Falciparum Malaria

February 23, 2012 - 09:28 -- Kabogo Ndegwa
Author(s): 
J Tarning, I Zongo, F A Somé, N Rouamba, S Parikh, P J Rosenthal, W Hanpithakpong, N Jongrak, N P J Day, N J White, F Nosten, J-B Ouedraogo and N Lindegardh
Reference: 
Clinical Pharmacology & Therapeutics (2012); 91 3, 497–505

MalariaWorldDihydroartemisinin-piperaquine is being increasingly used as a first-line artemisinin combination treatment for malaria.

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Open Access | Population Pharmacokinetics and Pharmacodynamics of Piperaquine in Children With Uncomplicated Falciparum Malaria

February 17, 2012 - 14:14 -- Patrick Sampao
Author(s): 
J Tarning, I Zongo, F A Somé, N Rouamba, S Parikh, P J Rosenthal, W Hanpithakpong, N Jongrak, N P J Day, N J White, F Nosten, J-B Ouedraogo and N Lindegardh
Reference: 
Clinical Pharmacology & Therapeutics (2012); 91 3, 497–505.

MalariaWorldThe aim of this study was to describe the pharmacokinetic and pharmacodynamic properties of piperaquine in 236 children with uncomplicated falciparum malaria in Burkina Faso.

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