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sickle cell

Not Open Access | Sickle Cell MicroRNAs Inhibit the Malaria Parasite

August 20, 2012 - 10:58 -- Patrick Sampao
Author(s): 
Manoj T. Duraisingh, Harvey F. Lodish
Reference: 
Cell Host & Microbe, Volume 12, Issue 2, 16 August 2012, Pages 127-128

MalariaWorldIn this issue of Cell Host & Microbe, demonstrate a surprising mechanism for this innate immunity.

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Open Access | Global distribution of the sickle cell gene and geographical confirmation of the malaria hypothesis

January 18, 2012 - 11:53 -- Patrick Sampao
Author(s): 
Frédéric B. Piel, Anand P. Patil, Rosalind E. Howes, Oscar A. Nyangiri, Peter W. Gething, Thomas N. Williams, David J. Weatherall & Simon I. Hay
Reference: 
Nature Communications Volume: 1: 104

MalariaWorldHere, we use a comprehensive data assembly of HbS allele frequencies to generate the first evidence-based map of the worldwide distribution of the gene in a Bayesian geostatistical framework.

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An Antioxidant Link between Sickle Cell Disease and Severe Malaria

May 4, 2011 - 10:12 -- Kabogo Ndegwa
Author(s): 
Ashraful Haque, Christian R. Engwerda
Reference: 
Cell, Volume 145, Issue 3, 29 April 2011, Pages 335-336

Although a link between sickle cell disease and resistance to severe malaria is well established, the biochemical relationship between the two is unknown.

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Open Access | Clinical Trials and Observations: High mortality from Plasmodium falciparum malaria in children living with sickle cell anemia on the coast of Kenya

September 10, 2010 - 13:29 -- Kabogo Ndegwa
Author(s): 
Charlotte F. McAuley, Clare Webb, Julie Makani, Alexander Macharia, Sophie Uyoga, Daniel H. Opi, Carolyne Ndila, Antony Ngatia, John Anthony G. Scott, Kevin Marsh, and Thomas N. Williams
Reference: 
Blood, 9 September 2010, Vol. 116, No. 10, pp. 1663-1668.

Although malaria is widely considered a major cause of death in young children born with sickle cell anemia (SCA) in sub-Saharan Africa, this is poorly quantified. We attempted to investigate this question through 4 large case-control analyses involving 7164 children living on the coast of Kenya.

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Malaria in patients with sickle cell anemia: burden, risk factors and outcome at outpatient clinic and during hospitalization

November 13, 2009 - 09:30 -- Ingeborg van Schayk
Author(s): 
J K Makani, A N Komba, S E Cox, J Oruo, K Mwamtemi, J Kitundu, P Magesa, S Rwezaula, E Meda, J Mgaya, K Pallangyo, E Okiro, D Muturi, C R Newton, G Fegan, K Marsh and T N Williams
Reference: 
Blood, November 9, 2009; DOI 10.1182/blood-2009-07-233528

We conducted a 5-year prospective surveillance study for malaria parasitemia, clinical malaria and severe malarial anemia (SMA) in Dar-es-Salaam, Tanzania between 2004 and 2009.

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Presumptive treatment with sulphadoxine-pyrimethamine versus weekly chloroquine for malaria prophylaxis in children with sickle cell anaemia in Uganda: a randomized controlled trial

October 29, 2009 - 12:18 -- Ingeborg van Schayk
Author(s): 
Presumptive treatment with sulphadoxine-pyrimethamine versus weekly chloroquine for malaria prophylaxis in children with sickle cell anaemia in Uganda: a randomized controlled trial Victoria Nakibuuka, Grace Ndeezi, Deborah Nakiboneka, Christopher M Ndugwa, James K Tumwine
Reference: 
Malaria Journal 2009, 8:237 (24 October 2009)

Malaria carries high case fatality among children with sickle cell anaemia. In Uganda, chloroquine is used for prophylaxis in these children despite unacceptably high levels of resistance. Intermittent presumptive treatment with sulphadoxine-pyrimethamine (SP) has shown great potential for reducing prevalence of malaria and anaemia among pregnant women and infants.

Presumptive treatment with SP was more efficacious than weekly chloroquine in reducing prevalence of malaria in children with sickle cell anaemia. Continued use of chloroquine for malaria chemoprophylaxis in children with sickle cell anaemia in Uganda does not seem to be justified. ClinicalTrials.gov Identifier: NCTOO124267

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