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prophylaxis

Plasmodium falciparum Infection during Suppressive Prophylaxis with Mefloquine Does Not Induce an Antibody Response to Merozoite Surface Protein-1(42)

May 5, 2011 - 09:30 -- Patrick Sampao
Author(s): 
James E. Moon, Gregory A. Deye, Lori Miller, Susan Fracisco, R. Scott Miller, Donna Tosh, James F. Cummings, Colin Ohrt, AND Alan J. Magill
Reference: 
Am J Trop Med Hyg, May 2011; 84: 825 - 829.

We conclude that malaria infection during suppressive prophylaxis does not induce antibody response to the blood-stage antigen MSP142 in a malaria-naïve study population.

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Presumptive treatment with sulphadoxine-pyrimethamine versus weekly chloroquine for malaria prophylaxis in children with sickle cell anaemia in Uganda: a randomized controlled trial

October 29, 2009 - 12:18 -- Ingeborg van Schayk
Author(s): 
Presumptive treatment with sulphadoxine-pyrimethamine versus weekly chloroquine for malaria prophylaxis in children with sickle cell anaemia in Uganda: a randomized controlled trial Victoria Nakibuuka, Grace Ndeezi, Deborah Nakiboneka, Christopher M Ndugwa, James K Tumwine
Reference: 
Malaria Journal 2009, 8:237 (24 October 2009)

Malaria carries high case fatality among children with sickle cell anaemia. In Uganda, chloroquine is used for prophylaxis in these children despite unacceptably high levels of resistance. Intermittent presumptive treatment with sulphadoxine-pyrimethamine (SP) has shown great potential for reducing prevalence of malaria and anaemia among pregnant women and infants.

Presumptive treatment with SP was more efficacious than weekly chloroquine in reducing prevalence of malaria in children with sickle cell anaemia. Continued use of chloroquine for malaria chemoprophylaxis in children with sickle cell anaemia in Uganda does not seem to be justified. ClinicalTrials.gov Identifier: NCTOO124267

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