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parasitemia

Open Access | Automated estimation of parasitaemia of Plasmodium yoelii-infected mice by digital image analysis of Giemsa-stained thin blood smears

December 3, 2010 - 08:47 -- Kabogo Ndegwa
Author(s): 
Ma C, Harrison P, Wang L, Coppel RL
Reference: 
Malaria Journal 2010, 9:348 (1 December 2010)

Plasmodium AutoCount has proven to be a useful tool for rapid and accurate determination of parasitaemia from infected mouse blood.

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Open Access | Effector Memory Th1 CD4 T Cells Are Maintained in a Mouse Model of Chronic Malaria

November 26, 2010 - 09:52 -- Kabogo Ndegwa
Author(s): 
Robin Stephens, Jean Langhorne
Reference: 
PLoS Pathog 6(11): e1001208

Protection against malaria often decays in the absence of infection, suggesting that protective immunological memory depends on stimulation.

Afebrile Plasmodium falciparum parasitemia decreases absorption of fortification iron but does not affect systemic iron utilization: a double stable-isotope study in young Beninese women

November 24, 2010 - 09:39 -- Patrick Sampao
Author(s): 
Colin I Cercamondi., Ines M Egli.,Michael B Zimmermann., et al.
Reference: 
Am J Clin Nutr December 2010 vol. 92 no. 6 1385-1392

We investigated whether asymptomatic Plasmodium falciparum parasitemia in Beninese women would impair absorption of dietary iron or utilization of circulating iron.

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Monitoring the Uptake of Glycosphingolipids In Plasmodium falciparum-Infected Erythrocytes Using Both Fluorescence Microscopy and Capillary Electrophoresis with Laser-Induced Fluorescence Detection

November 9, 2010 - 08:52 -- Kabogo Ndegwa
Author(s): 
DC Essaka, J White, P Rathod, CD Whitmore, O Hindsgaul, MM Palcic, NJ Dovichi
Reference: 
Analytical Chemistry, 2 November 2010

The metabolism of glycosphingolipids by the malaria-causing parasite Plasmodium falciparum plays an important role in the progression of the disease. We report a new and highly sensitive method to monitor the uptake of glycosphingolipids in infected red blood cells (iRBCs).

Open Access | Fine specificity of anti-MSP119 antibodies and multiplicity of Plasmodium falciparum Merozoite Surface Protein 1 types in individuals in Nigeria with sub-microscopic infection

October 22, 2010 - 08:48 -- Kabogo Ndegwa
Author(s): 
Ngoundou-Landji J, Nwuba RI, Anumudu CI, Odaibo AB, Matondo Maya WD, Awobode HO, Okafor CM, Morenikeji OA, Asinobi A, Nwagwu M, Holder AA, Ntoumi F
Reference: 
Malaria Journal 2010, 9:287 (18 October 2010)

In the search for correlates of protection against malaria, which will be essential to evaluate clinical trials of malaria vaccines based on MSP1, this study examines some potential assays and the factors that need to taken into account during their evaluation, using samples from individuals naturally exposed to malaria infection.

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Plasma Concentration of Malaria Parasite-Derived Macrophage Migration Inhibitory Factor in Uncomplicated Malaria Patients Correlates with Parasitemia and Disease Severity

October 4, 2010 - 08:29 -- Kabogo Ndegwa
Author(s): 
Cong Han, Yahui Lin, Guangliang Shan, Zaixing Zhang, Xiaodong Sun, Zhensheng Wang, Chunyan Wei, Yan Deng, Lianhui Zhang, Lingyi Bu, Dingding Shao, and Heng Wang
Reference: 
Clin. Vaccine Immunol. 2010;17 1524-1532

Host macrophage migration inhibitory factor (MIF) has been implicated in the pathogenesis of malaria infections. Several Plasmodium parasite-derived MIFs were identified to have the potential to regulate host immune response.

Evaluation of Recurrent Parasitemia after Artemether-Lumefantrine Treatment for Uncomplicated Malaria in Children in Western Kenya

September 2, 2010 - 13:16 -- Patrick Sampao
Author(s): 
Joseph V. Woodring, Bernhards Ogutu, David Schnabel, John N. Waitumbi, Cara H. Olsen, Douglas S. Walsh, D. Gray Heppner, Jr.,and Mark E. Polhemus
Reference: 
Am. J. Trop. Med. Hyg., 83(3), 2010, pp. 458-464

Although recrudescence in some cannot be ruled out, our cohort had a shorter median time to RP compared with other artemether-lumefantrine treatment studies.

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Priority Paper Evaluation: How do malaria parasites activate dendritic cells?

August 24, 2010 - 12:15 -- Kabogo Ndegwa
Author(s): 
Tracey J Lamb, Michael P Schenk, Stephen M Todryk
Reference: 
Future Microbiology August 2010, Vol. 5, No. 8, Pages 1167-1171

The authors suggest that parasite DNA complexed with protein is the main trigger for activation of DCs in malaria-infected red blood cells.

Dynamics of Plasmodium falciparum Parasitemia Regarding Combined Treatment Regimens for Acute Uncomplicated Malaria, Antioquia, Colombia

July 5, 2010 - 06:49 -- Patrick Sampao
Author(s): 
Gonzalo Álvarez, Alberto Tobón, Juan-Gabriel Piñeros, Alexandra Ríos, AND Silvia Blair
Reference: 
Am J Trop Med Hyg, Jul 2010; 83: 90 - 96.

Sexual and asexual parasite dynamics were thus evaluated in patients involved in antimalarial drug efficacy studies by using combined treatment with and without artemisinin derivatives for treating uncomplicated acute Plasmodium falciparum malaria in Antioquia, Colombia.

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Intravenous Ibuprofen (IV-ibuprofen) Controls Fever Effectively in Adults with Acute Uncomplicated Plasmodium falciparum Malaria but Prolongs Parasitemia

July 2, 2010 - 13:39 -- Patrick Sampao
Author(s): 
Srivicha K., Noppadon T., et al.
Reference: 
Am J Trop Med Hyg, Jul 2010; 83: 51 - 55.

Because some febrile patients are unable to swallow or retain oral antipyretic drugs, we carried out a double-blind, placebo-controlled trial in which intravenous ibuprofen (IV-ibuprofen) was given to adults hospitalized with fever associated with acute uncomplicated falciparum malaria treated with oral artesunate plus mefloquine.

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