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parasitemia

Partitioning Regulatory Mechanisms of Within-Host Malaria Dynamics Using the Effective Propagation Number

August 25, 2011 - 10:14 -- Patrick Sampao
Author(s): 
C. J. E. Metcalf, A. L. Graham, S. Huijben, V. C. Barclay, G. H. Long, B. T. Grenfell, A. F. Read, O. N. Bjørnstad
Reference: 
Science :Vol. 333 no. 6045 pp. 984-988, 19 August 2011

Our analysis showed that the capacity of innate responses to restrict initial parasite growth saturates with parasite dose and that experimentally enhanced innate immunity can affect parasite density indirectly via resource depletion.

Medical Condition: 

Perspective: Quantifying Malaria Dynamics Within the Host

August 24, 2011 - 14:53 -- Patrick Sampao
Author(s): 
Karen P. Day, Freya J. I. Fowkes
Reference: 
Science : Vol. 333 no. 6045 pp. 943-944, 19 August 2011

Drawing on data from mice, they present a new statistical approach to analyzing how parasitemia changes over time and to quantifying and comparing the roles played by the immune system and the availability of red blood cells in regulating parasite numbers.

Medical Condition: 

Signalling through the IL-2 receptor [gamma]c peptide (CD132) is essential for the expression of immunity to Plasmodium chabaudi adami blood-stage malaria (pages 512–516)

August 16, 2011 - 12:57 -- Kabogo Ndegwa
Author(s): 
W. P. Weidanz, G. LaFleur, A. Kita-Yarbro, K. Nelson, J. M. Burns JR
Reference: 
Parasite Immunology, Volume 33, Issue 9, pages 512–516, September 2011

A genetic dissection approach was employed to determine whether the IL-2 receptor complex (IL-2R) comprised of α, β and γ chains is required for the suppression of Plasmodium chabaudi adami parasitemia.

Open Access | PNAS Plus: Linkage maps from multiple genetic crosses and loci linked to growth-related virulent phenotype in Plasmodium yoelii

August 3, 2011 - 09:36 -- Kabogo Ndegwa
Author(s): 
Jian Li, Sittiporn Pattaradilokrat, Feng Zhu, Hongying Jiang, Shengfa Liu, Lingxian Hong, Yong Fu, Lily Koo, Wenyue Xu, Weiqing Pan, Jane M. Carlton, Osamu Kaneko, Richard Carter, John C. Wootton, and Xin-zhuan Su
Reference: 
PNAS August 2, 2011 vol. 108 no. 31 E374-E382

Plasmodium yoelii is an excellent model for studying malaria pathogenesis that is often intractable to investigate using human parasites;

Comparative Immunogenicities of Full-Length Plasmodium falciparum Merozoite Surface Protein 3 and a 24-Kilodalton N-Terminal Fragment

August 3, 2011 - 09:28 -- Kabogo Ndegwa
Author(s): 
Maryam Imam, Yengkhom Sangeeta Devi, Akhilesh K. Verma, and Virander Singh Chauhan
Reference: 
Clinical and Vaccine Immunology, August 2011,p. 1221-1228, Vol. 18, No. 8

Recombinant Plasmodium falciparum merozoite surface protein 3 (PfMSP3F) and a 24-kDa fragment from its N terminus (MSP3N) that includes the essential conserved domain, which elicits the maximum antibody (Ab)-dependent cellular inhibition (ADCI), were expressed as soluble proteins in Escherichia coli. Both proteins were found to be stable in both soluble and lyophilized forms.

Antiplasmodial activity of botanical extracts against Plasmodium falciparum

April 20, 2011 - 07:49 -- Kabogo Ndegwa
Author(s): 
Asokan Bagavan, Abdul Abdul Rahuman, Chinnaperumal Kamaraj, Naveen Kumar Kaushik, Dinesh Mohanakrishnan & Dinkar Sahal
Reference: 
Parasitology Research, Volume 108, Number 5, 1099-1109

The absence of a vaccine and the rampant resistance to almost all antimalarial drugs have accentuated the urgent need for new antimalarial drugs and drug targets for both prophylaxis and chemotherapy.

Medical Treatment: 

Hepatic miRNA expression reprogrammed by Plasmodium chabaudi malaria

April 20, 2011 - 07:46 -- Kabogo Ndegwa
Author(s): 
Denis Delić, Mohamed Dkhil, Saleh Al-Quraishy & Frank Wunderlich
Reference: 
Parasitology Research, Volume 108, Number 5, 1111-1121

Evidence is accumulating that miRNAs are critically implicated in the outcome of diseases, but little information is available for infectious diseases.

Histopathological studies in two strains of semi-immune mice infected with Plasmodium berghei ANKA after chronic exposure

March 22, 2011 - 10:08 -- Kabogo Ndegwa
Author(s): 
Gideon Kofi Helegbe, Tetsuo Yanagi, Masachika Senba, Nguyen Tien Huy, Mohammed Nasir Shuaibu, Akiko Yamazaki, Mihoko Kikuchi, Michio Yasunami & Kenji Hirayama
Reference: 
Parasitology Research, Volume 108, Number 4, 807-814

To mimic a human malaria infection in the endemic condition, two strains of mice (Balb/c and CBA) were infected and treated several times to generate so-called semi-immune status.

Medical Treatment: 

Survival of Plasmodium falciparum in human blood during refrigeration

March 11, 2011 - 08:35 -- Kabogo Ndegwa
Author(s): 
Rana Chattopadhyay, Victoria F. Majam and Sanjai Kumar
Reference: 
Transfusion, Volume 51, Issue 3, pages 630–635, March 2011

Although the storage of asexual blood-stage P. falciparum parasites at 4°C is detrimental to their survival (a 7.1-fold reduction in parasitemia after 14 days in storage), parasites remained microscopically detectable for 28 days, the end time point of our study.

Open Access | CD4+ Natural Regulatory T Cells Prevent Experimental Cerebral Malaria via CTLA-4 When Expanded In Vivo

December 16, 2010 - 07:24 -- Kabogo Ndegwa
Author(s): 
Ashraful Haque, Shannon E. Best, Fiona H. Amante, Seri Mustafah, Laure Desbarrieres, Fabian de Labastida, Tim Sparwasser, Geoffrey R. Hill, Christian R. Engwerda
Reference: 
PLoS Pathog 6(12): e1001221

Studies in malaria patients indicate that higher frequencies of peripheral blood CD4+ Foxp3+ CD25+ regulatory T (Treg) cells correlate with increased blood parasitemia.

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