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malaria parasite

Open Access | Long- and Short-Term Selective Forces on Malaria Parasite Genomes

October 4, 2010 - 13:02 -- Kabogo Ndegwa
Author(s): 
Sanne Nygaard, Alexander Braunstein, Daniel C. Jeffares, et al.
Reference: 
PLoS Genet 6(9): e1001099

Plasmodium parasites, the causal agents of malaria, result in more than 1 million deaths annually. Plasmodium are unicellular eukaryotes with small ~23 Mb genomes encoding ~5200 protein-coding genes.

Open Access | The Armadillo Repeat Protein PF16 Is Essential for Flagellar Structure and Function in Plasmodium Male Gametes

October 4, 2010 - 09:19 -- Kabogo Ndegwa
Author(s): 
Ursula Straschil, Arthur M. Talman, David J. P. Ferguson, Karen A. Bunting, Zhengyao Xu, Elizabeth Bailes, Robert E. Sinden, Anthony A. Holder, Elizabeth F. Smith, Juliet C. Coates, Rita Tewari
Reference: 
PLoS ONE 5(9): e12901

Malaria, caused by the apicomplexan parasite Plasmodium, threatens 40% of the world's population. Transmission between vertebrate and insect hosts depends on the sexual stages of the life-cycle.

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Plasma Concentration of Malaria Parasite-Derived Macrophage Migration Inhibitory Factor in Uncomplicated Malaria Patients Correlates with Parasitemia and Disease Severity

October 4, 2010 - 08:29 -- Kabogo Ndegwa
Author(s): 
Cong Han, Yahui Lin, Guangliang Shan, Zaixing Zhang, Xiaodong Sun, Zhensheng Wang, Chunyan Wei, Yan Deng, Lianhui Zhang, Lingyi Bu, Dingding Shao, and Heng Wang
Reference: 
Clin. Vaccine Immunol. 2010;17 1524-1532

Host macrophage migration inhibitory factor (MIF) has been implicated in the pathogenesis of malaria infections. Several Plasmodium parasite-derived MIFs were identified to have the potential to regulate host immune response.

Open Access | Antiprotozoal activity of drimane and coloratane sesquiterpenes towards Trypanosoma brucei rhodesiense and Plasmodium falciparum in vitro (pages 1468–1472)

September 30, 2010 - 07:31 -- Kabogo Ndegwa
Author(s): 
Abraham Abebe Wube, Franz Bucar, Simon Gibbons, Kaleab Asres, Lauren Rattray and Simon L. Croft
Reference: 
Phytotherapy Research, Volume 24, Issue 10, pages 1468–1472, October 2010

The extracts and 12 sesquiterpenes obtained from the East African medicinal plant Warburgia ugandensis Sprague (Canellaceae) were assessed for their antiplasmodial activity against the chloroquine-sensitive (3D7) and chloroquine-resistant (K1) strains of Plasmodium falciparum and antitrypanosomal activity against Trypanosoma brucei rhodesiense.

Open Access | Glutathione Reductase-null Malaria Parasites Have Normal Blood Stage Growth but Arrest during Development in the Mosquito

August 25, 2010 - 08:48 -- Kabogo Ndegwa
Author(s): 
Rebecca Pastrana-Mena, Rhoel R. Dinglasan, Adelfa E. Serrano, et al
Reference: 
The Journal of Biological Chemistry, August 27, 2010, 285 27045-27056

Malaria parasites contain a complete glutathione (GSH) redox system, and several enzymes of this system are considered potential targets for antimalarial drugs.

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Quantitative Imaging of Human Red Blood Cells Infected with Plasmodium falciparum

August 10, 2010 - 09:48 -- Kabogo Ndegwa
Author(s): 
A Esposito, JB Choimet, JN Skepper, JM Mauritz, VL Lew, CF Kaminski, T Tiffert
Reference: 
Biophysical Journal, Volume 99, Issue 3, 953-960, 4 August 2010

During its 48 h asexual reproduction cycle, the malaria parasite Plasmodium falciparum ingests and digests hemoglobin in excess of its metabolic requirements and causes major changes in the homeostasis of the host red blood cell (RBC).

Letter: Branched tricarboxylic acid metabolism in Plasmodium falciparum

August 5, 2010 - 11:46 -- Kabogo Ndegwa
Author(s): 
Kellen L. Olszewski, Michael W. Mather, Joanne M. Morrisey, Benjamin A. Garcia, Akhil B. Vaidya, Joshua D. Rabinowitz, Manuel Llinás
Reference: 
Nature 466, 774-778, 5 August 2010

A central hub of carbon metabolism is the tricarboxylic acid cycle1, which serves to connect the processes of glycolysis, gluconeogenesis, respiration, amino acid synthesis and other biosynthetic pathways.

Open Access | Protein Kinase A Dependent Phosphorylation of Apical Membrane Antigen 1 Plays an Important Role in Erythrocyte Invasion by the Malaria Parasite

June 7, 2010 - 11:47 -- Kabogo Ndegwa
Author(s): 
Kerstin Leykauf, Moritz Treeck, Paul R. Gilson, Thomas Nebl, Thomas Braulke, Alan F. Cowman, Tim W. Gilberger, Brendan S. Crabb
Reference: 
PLoS Pathog 6(6): e1000941

Apicomplexan parasites are obligate intracellular parasites that infect a variety of hosts, causing significant diseases in livestock and humans. The invasive forms of the parasites invade their host cells by gliding motility, an active process driven by parasite adhesion proteins and molecular motors.

Open Access | Using the entomological inoculation rate to assess the impact of vector control on malaria parasite transmission and elimination

May 13, 2010 - 14:39 -- Kabogo Ndegwa
Author(s): 
Shaukat AM, Breman JG, McKenzie F
Reference: 
Malaria Journal 2010, 9:122 (12 May 2010)

These studies indicate that current vector control methods alone cannot ultimately eradicate malaria because no intervention sustained an annual EIR less than one. While researchers develop new tools, integrated vector management may make the greatest impact on malaria transmission. There are many gaps in the entomological malaria literature and recommendations for future research are provided.

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Open Access | Transcriptional Analysis of the Pre-Erythrocytic Stages of the Rodent Malaria Parasite, Plasmodium yoelii

April 22, 2010 - 13:13 -- Kabogo Ndegwa
Author(s): 
Calvin T. Williams, Abdu F. Azad
Reference: 
PLoS ONE 5(4): e10267

The molecular biology of the clinically silent pre-erythrocytic stages of mammalian Plasmodium spp, composed of both the sporozoite and liver stages, has remained largely uncharacterized. Improved understanding of the biological processes required for progression through the pre-erythrocytic stages could lead to the identification of novel drug and vaccine targets.

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