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malaria parasite

In search of the malarial parasite

August 31, 2011 - 07:26 -- Kabogo Ndegwa
Kristine Krafts, Ernst Hempelmann & Barbara J. Oleksyn
Parasitology Research, Volume 109, Number 3, 521-529

Methylene blue was synthesized by Caro in 1876 at BASF, a chemical company. Six years later, Koch employed methylene blue when he discovered the tubercle bacillus.

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Open Access | Biophysics of Malarial Parasite Exit from Infected Erythrocytes

June 28, 2011 - 06:32 -- Kabogo Ndegwa
Rajesh Chandramohanadas, YongKeun Park, Lena Lui, Ang Li, David Quinn, Kingsley Liew, Monica Diez-Silva, Yongjin Sung, Ming Dao, Chwee Teck Lim, Peter Rainer Preiser, Subra Suresh
PLoS ONE 6(6): e20869

Upon infection and development within human erythrocytes, P. falciparum induces alterations to the infected RBC morphology and bio-mechanical properties to eventually rupture the host cells through parasitic and host derived proteases of cysteine and serine families.

Open Access | Environmental Constraints Guide Migration of Malaria Parasites during Transmission

June 22, 2011 - 06:50 -- Kabogo Ndegwa
Janina Kristin Hellmann, Sylvia Münter, Mikhail Kudryashev, Simon Schulz, Kirsten Heiss, Ann-Kristin Müller, Kai Matuschewski, Joachim P. Spatz, Ulrich S. Schwarz, Friedrich Frischknecht
PLoS Pathog 7(6): e1002080

Migrating cells are guided in complex environments mainly by chemotaxis or structural cues presented by the surrounding tissue.

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Open Access | Activation of a PAK-MEK signalling pathway in malaria parasite-infected erythrocytes

June 8, 2011 - 15:06 -- Patrick Sampao
Audrey Sicard, Jean-Philippe Semblat, Christian Doerig, et al
Cellular Microbiology, Volume 13, Issue 6, pages 836–845, June 2011

Here, we report that a protein kinase-mediated signalling pathway involving host RBC PAK1 and MEK1, which do not have orthologues in the Plasmodium kinome, is selectively stimulated in Plasmodium falciparum-infected (versus uninfected) RBCs, as determined by the use of phospho-specific antibodies directed against the activated forms of these enzymes.

Open Access | The Puf-Family RNA-Binding Protein Puf2 Controls Sporozoite Conversion to Liver Stages in the Malaria Parasite

May 24, 2011 - 08:58 -- Kabogo Ndegwa
Katja Müller, Kai Matuschewski, Olivier Silvie
PLoS ONE 6(5): e19860

Malaria is a vector-borne infectious disease caused by unicellular, obligate intracellular parasites of the genus Plasmodium.

Open Access | Plasmodium falciparum Reticulocyte Binding-Like Homologue Protein 2 (PfRH2) Is a Key Adhesive Molecule Involved in Erythrocyte Invasion

March 8, 2011 - 07:24 -- Kabogo Ndegwa
Tajali Sahar, K. Sony Reddy, Mitasha Bharadwaj, Alok K. Pandey, Shailja Singh, Chetan E. Chitnis, Deepak Gaur
PLoS ONE 6(2): e17102

Erythrocyte invasion by Plasmodium merozoites is a complex, multistep process that is mediated by a number of parasite ligand-erythrocyte receptor interactions.

Open Access | Identification and Genome-Wide Prediction of DNA Binding Specificities for the ApiAP2 Family of Regulators from the Malaria Parasite

November 2, 2010 - 08:00 -- Kabogo Ndegwa
Tracey L. Campbell, Erandi K. De Silva, Kellen L. Olszewski, Olivier Elemento, Manuel Llinás
PLoS Pathog 6(10): e1001165

The molecular mechanisms underlying transcriptional regulation in apicomplexan parasites remain poorly understood.


Open Access | Comparison of real-time PCR and microscopy for malaria parasite detection in Malawian pregnant women

October 11, 2010 - 08:10 -- Kabogo Ndegwa
Rantala A, Taylor SM, Trottman PA, Luntamo M, Mbewe B, Maleta K, Kulmala T, Ashorn P, Meshnick SR
Malaria Journal 2010, 9:269 (6 October 2010)

Although microscopy remains the most appropriate method for clinical malaria diagnosis in field settings, molecular diagnostics such as real-time PCR offer a more reliable means to detect malaria parasites, particularly at low levels.


Single nucleotide polymorphisms, putatively neutral DNA markers and population genetic parameters in Indian Plasmodium vivax isolates

October 11, 2010 - 07:48 -- Kabogo Ndegwa
Bhavna Gupta, Aditya P. Dash, Nalini Shrivastava, Aparup Das
Parasitology, Volume 137, Issue 12, October 2010, pp 1721 – 1730

With a view to developing putatively neutral markers based on Single Nucleotide Polymorphisms (SNPs) in the human malaria parasite, Plasmodium vivax, we utilized the published whole genome sequence information of P. falciparum and P. vivax to find a ~200 kb conserved syntenic region between these two species.


Plasmodium falciparum Tudor Staphylococcal Nuclease interacting proteins suggest its role in nuclear as well as splicing processes

October 6, 2010 - 07:58 -- Kabogo Ndegwa
Manzar J. Hossain, Reshma Korde, Prashant K. Singh, Shivani Kanodia, Ravi Ranjan, Geeta Ram, Gaganjot Singh Kalsey, Rita Singh, Pawan Malhotra
Gene, Volume 468, Issues 1-2, 15 November 2010, Pages 48-57

Tudor Staphylococcal Nuclease (p100 or SND1), a member of the micronuclease family is a multifunctional protein that plays a key role(s) in transcription and splicing processes in many eukaryotic cells.


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