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A GFP-Actin reporter line to explore microfilament dynamics across the malaria parasite lifecycle

February 9, 2012 - 08:31 -- Patrick Sampao
Fiona Angrisano, Michael J. Delves, Angelika Sturm, Vanessa Mollard, Geoffrey I. McFadden, Robert E. Sinden, Jake Baum
Molecular and Biochemical Parasitology, Volume 182, Issues 1–2, March–April 2012, Pages 93-96

MalariaWorldHowever, following treatment with the actin filament-stabilizing drug Jasplakinolide, we show evidence for concentration of F-actin dynamics in the parasite pellicle and at polar apices.

Medical Condition: 

Open Access | Identification and molecular characterization of an Alba-family protein from human malaria parasite Plasmodium falciparum

February 8, 2012 - 08:23 -- Patrick Sampao
Manish Goyal, Athar Alam, Mohd Shameel Iqbal, Sumanta Dey, Samik Bindu, Chinmay Pal, Anindyajit Banerjee, Saikat Chakrabarti and Uday Bandyopadhyay
Nucl. Acids Res. (2012) 40 (3): 1174-1190.

MalariaWorldWe have investigated the DNA-binding nature as well as the function of a putative Alba (Acetylation lowers binding affinity) family protein (PfAlba3) from Plasmodium falciparum.

Review: Defining the protein interaction network of human malaria parasite Plasmodium falciparum

February 2, 2012 - 09:05 -- Patrick Sampao
Abhinay Ramaprasad, Arnab Pain, Timothy Ravasi
Genomics, Volume 99, Issue 2, February 2012, Pages 69–75

MalariaWorldThis review aims to discuss the computational approaches used till date to construct a malaria protein interaction network and to catalog the functional predictions and biological inferences made from analysis of the PPI network.


Molecular analysis of Plasmodium falciparum co-chaperone Aha1 supports its interaction with and regulation of Hsp90 in the malaria parasite

December 22, 2011 - 09:17 -- Patrick Sampao
Chun Song Chua, Huiyu Low, Norbert Lehming, T.S. Sim
The International Journal of Biochemistry & Cell Biology, Volume 44, Issue 1, January 2012, Pages 233-245

MalariaWorldIn this study, a putative co-chaperone P. falciparum Aha1 (PfAha1) was identified and investigated for its interaction and regulation of PfHsp90.

Plasmodium knowlesi: A Malaria Parasite of Monkeys and Humans

December 9, 2011 - 14:45 -- Patrick Sampao
William E. Collins
Annual Review of Entomology, Vol. 57: 107-121 (January 2012)

MalariaWorldThe parasite was a major monkey animal model for developing antimalarial vaccines and investigations of the biology of parasite invasion. P. knowlesi is the first monkey malaria parasite genome to be sequenced and annotated.


Mini-review: Helicases involved in splicing from malaria parasite Plasmodium falciparum

November 25, 2011 - 14:15 -- Patrick Sampao
Renu Tuteja
Parasitology International, Volume 60, Issue 4, December 2011, Pages 335-340

MalariaWorldThis article will focus on members of the DExD/H-box proteins involved specially in splicing in the malaria parasite Plasmodium falciparum.

Virulence of a Malaria Parasite, Plasmodium mexicanum, for Its Sand Fly Vectors, Lutzomyia vexator and Lutzomyia stewarti (Diptera: Psychodidae)

November 23, 2011 - 14:52 -- Patrick Sampao
Jos. J. Schall
Journal of Medical Entomology 48(6):1183-1188. 2011

MalariaWorldThis report is the first measure of virulence of Plasmodium for an insect vector other than a mosquito and concords with both expectations of theory and previous studies on natural parasite-host associations that revealed low virulence.

Open Access | A rapid and robust tri-color flow cytometry assay for monitoring malaria parasite development

October 31, 2011 - 14:45 -- Patrick Sampao
Benoît Malleret, Carla Claser, Alice Soh Meoy Ong, Rossarin Suwanarusk, Kanlaya Sriprawat, Shanshan Wu Howland, Bruce Russell, Francois Nosten & Laurent Rénia
Scientific Reports, Volume: 1:118

MalariaWorldThis protocol, which does not require any washing steps, allows infected red blood cells to be distinguished from leukocytes, as well as allowing non-infected reticulocytes and normocytes to be identified.

Infection Intensity-Dependent Responses of Anopheles gambiae to the African Malaria Parasite Plasmodium falciparum

October 17, 2011 - 08:29 -- Patrick Sampao
Antonio M. Mendes, Parfait H. Awono-Ambene, Sandrine E. Nsango, Anna Cohuet, Didier Fontenille, Fotis C. Kafatos, George K. Christophides, Isabelle Morlais, and Dina Vlachou
Infect. Immun., Nov 2011; 79: 4708 - 4715.

MalariaWorldThese data suggest that coadaptation between vectors and parasites may act to minimize the impact of infection on mosquito fitness by selectively suppressing specific functional classes of genes.


Comparative efficacy of pre-erythrocytic whole organism vaccine strategies against the malaria parasite

October 6, 2011 - 08:18 -- Patrick Sampao
Johannes Friesen, Kai Matuschewski
Vaccine, Volume 29, Issue 40, 16 September 2011, Pages 7002-7008

Together, we show that systematic pre-clinical evaluation and quantification of vaccine efficacy is vital for identification of the most potent whole organism anti-malaria vaccine strategy.

Medical Treatment: 


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