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A GFP-Actin reporter line to explore microfilament dynamics across the malaria parasite lifecycle

February 9, 2012 - 08:31 -- Patrick Sampao
Author(s): 
Fiona Angrisano, Michael J. Delves, Angelika Sturm, Vanessa Mollard, Geoffrey I. McFadden, Robert E. Sinden, Jake Baum
Reference: 
Molecular and Biochemical Parasitology, Volume 182, Issues 1–2, March–April 2012, Pages 93-96

MalariaWorldHowever, following treatment with the actin filament-stabilizing drug Jasplakinolide, we show evidence for concentration of F-actin dynamics in the parasite pellicle and at polar apices.

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Open Access | Identification and molecular characterization of an Alba-family protein from human malaria parasite Plasmodium falciparum

February 8, 2012 - 08:23 -- Patrick Sampao
Author(s): 
Manish Goyal, Athar Alam, Mohd Shameel Iqbal, Sumanta Dey, Samik Bindu, Chinmay Pal, Anindyajit Banerjee, Saikat Chakrabarti and Uday Bandyopadhyay
Reference: 
Nucl. Acids Res. (2012) 40 (3): 1174-1190.

MalariaWorldWe have investigated the DNA-binding nature as well as the function of a putative Alba (Acetylation lowers binding affinity) family protein (PfAlba3) from Plasmodium falciparum.

Review: Defining the protein interaction network of human malaria parasite Plasmodium falciparum

February 2, 2012 - 09:05 -- Patrick Sampao
Author(s): 
Abhinay Ramaprasad, Arnab Pain, Timothy Ravasi
Reference: 
Genomics, Volume 99, Issue 2, February 2012, Pages 69–75

MalariaWorldThis review aims to discuss the computational approaches used till date to construct a malaria protein interaction network and to catalog the functional predictions and biological inferences made from analysis of the PPI network.

Person: 

Molecular analysis of Plasmodium falciparum co-chaperone Aha1 supports its interaction with and regulation of Hsp90 in the malaria parasite

December 22, 2011 - 09:17 -- Patrick Sampao
Author(s): 
Chun Song Chua, Huiyu Low, Norbert Lehming, T.S. Sim
Reference: 
The International Journal of Biochemistry & Cell Biology, Volume 44, Issue 1, January 2012, Pages 233-245

MalariaWorldIn this study, a putative co-chaperone P. falciparum Aha1 (PfAha1) was identified and investigated for its interaction and regulation of PfHsp90.

Plasmodium knowlesi: A Malaria Parasite of Monkeys and Humans

December 9, 2011 - 14:45 -- Patrick Sampao
Author(s): 
William E. Collins
Reference: 
Annual Review of Entomology, Vol. 57: 107-121 (January 2012)

MalariaWorldThe parasite was a major monkey animal model for developing antimalarial vaccines and investigations of the biology of parasite invasion. P. knowlesi is the first monkey malaria parasite genome to be sequenced and annotated.

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Mini-review: Helicases involved in splicing from malaria parasite Plasmodium falciparum

November 25, 2011 - 14:15 -- Patrick Sampao
Author(s): 
Renu Tuteja
Reference: 
Parasitology International, Volume 60, Issue 4, December 2011, Pages 335-340

MalariaWorldThis article will focus on members of the DExD/H-box proteins involved specially in splicing in the malaria parasite Plasmodium falciparum.

Virulence of a Malaria Parasite, Plasmodium mexicanum, for Its Sand Fly Vectors, Lutzomyia vexator and Lutzomyia stewarti (Diptera: Psychodidae)

November 23, 2011 - 14:52 -- Patrick Sampao
Author(s): 
Jos. J. Schall
Reference: 
Journal of Medical Entomology 48(6):1183-1188. 2011

MalariaWorldThis report is the first measure of virulence of Plasmodium for an insect vector other than a mosquito and concords with both expectations of theory and previous studies on natural parasite-host associations that revealed low virulence.

Open Access | A rapid and robust tri-color flow cytometry assay for monitoring malaria parasite development

October 31, 2011 - 14:45 -- Patrick Sampao
Author(s): 
Benoît Malleret, Carla Claser, Alice Soh Meoy Ong, Rossarin Suwanarusk, Kanlaya Sriprawat, Shanshan Wu Howland, Bruce Russell, Francois Nosten & Laurent Rénia
Reference: 
Scientific Reports, Volume: 1:118

MalariaWorldThis protocol, which does not require any washing steps, allows infected red blood cells to be distinguished from leukocytes, as well as allowing non-infected reticulocytes and normocytes to be identified.

Infection Intensity-Dependent Responses of Anopheles gambiae to the African Malaria Parasite Plasmodium falciparum

October 17, 2011 - 08:29 -- Patrick Sampao
Author(s): 
Antonio M. Mendes, Parfait H. Awono-Ambene, Sandrine E. Nsango, Anna Cohuet, Didier Fontenille, Fotis C. Kafatos, George K. Christophides, Isabelle Morlais, and Dina Vlachou
Reference: 
Infect. Immun., Nov 2011; 79: 4708 - 4715.

MalariaWorldThese data suggest that coadaptation between vectors and parasites may act to minimize the impact of infection on mosquito fitness by selectively suppressing specific functional classes of genes.

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Comparative efficacy of pre-erythrocytic whole organism vaccine strategies against the malaria parasite

October 6, 2011 - 08:18 -- Patrick Sampao
Author(s): 
Johannes Friesen, Kai Matuschewski
Reference: 
Vaccine, Volume 29, Issue 40, 16 September 2011, Pages 7002-7008

Together, we show that systematic pre-clinical evaluation and quantification of vaccine efficacy is vital for identification of the most potent whole organism anti-malaria vaccine strategy.

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