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circumsporozoite protein

Minimal Role for the Circumsporozoite Protein in the Induction of Sterile Immunity by Vaccination with Live Rodent Malaria Sporozoites

April 19, 2010 - 14:17 -- Patrick Sampao
Marjorie M., Rita T., et al.
Infection and Immunity, Vol. 78, No. 5 p. 2182-2188, May 2010

Here, we have employed transgenic Plasmodium berghei parasites in which the endogenous CSP was replaced by that of Plasmodium yoelii, another rodent malaria species, to assess the role of CSP in the sterile protection induced by the Spz-plus-CQ protocol.


Evolutionary dynamics of the immunodominant repeats of the Plasmodium vivax malaria-vaccine candidate circumsporozoite protein (CSP)

February 26, 2010 - 11:35 -- Kabogo Ndegwa
Aarti Patil, Pamela Orjuela-Sánchez, Mônica da Silva-Nunes, Marcelo U. Ferreira
Infection, Genetics and Evolution, Volume 10, Issue 2, March 2010, Pages 298-303

To determine whether rearrangements of repeat motifs during mitotic DNA replication of parasites create significant CSP diversity under conditions of low effective meiotic recombination rates, we examined csp alleles from sympatric P. vivax isolates systematically sampled from an area of low malaria endemicity in Brazil over a period of 14 months.

A bicomponent Plasmodium falciparum investigational vaccine composed of protein-peptide conjugates

January 20, 2010 - 09:42 -- Ingeborg van Schayk
Joanna Kubler-Kielb, Fathy Majadly, Zuzana Biesova, Christopher P. Mocca, Chunyan Guo, Ruth Nussenzweig, Victor Nussenzweig, Satish Mishra, Yimin Wu, Louis H. Miller, Jerry M. Keith, Teh-Yung Liu, John B. Robbins, and Rachel Schneerson
PNAS January 19, 2010 vol. 107 no. 3 1172-1177

To provide a CSP-based candidate vaccine, we investigated recombinant CSP and NANP conjugates of various peptide lengths, with different N-terminal amino acids, bound at different ratios to various carrier proteins.

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