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A molecular clock for malaria parasites

July 16, 2010 - 14:14 -- Kabogo Ndegwa
R.E Ricklefs, D.C Outlaw
Science 9 July 2010, Vol. 329. no. 5988, pp. 226 – 229

The evolutionary origins of new lineages of pathogens are fundamental to understanding emerging diseases. Phylogenetic reconstruction based on DNA sequences has revealed the sister taxa of human pathogens, but the timing of host-switching events, including the human malaria pathogen Plasmodium falciparum, remains controversial.

Open Access | Antiplasmodial Activity of Some Medicinal Plants Used in Sudanese Folk-medicine

June 8, 2010 - 09:34 -- Kabogo Ndegwa
Ahmed el-HM, Nour BY, Mohammed YG, Khalid HS.
Environ Health Insights. 2010 Feb 4;4:1-6

Ten plants indigenous to Sudan and of common use in Sudanese folk-medicine, were examined in vitro for antimalarial activity against schizonts maturation of Plasmodium falciparum, the major human malaria parasite.

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Open Access | Stress, drugs and the evolution of reproductive restraint in malaria parasites

May 25, 2010 - 09:18 -- Kabogo Ndegwa
SE Reece, E Ali, P Schneider, HA Babiker
Proc. R. Soc. B May 19

Life-history theory predicts that sexually reproducing organisms have evolved to resolve resource-allocation trade-offs between growth/survival versus reproduction, and current versus future reproduction.

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Review: IgM, FcµRs, and Malarial Immune Evasion

April 22, 2010 - 12:03 -- Kabogo Ndegwa
Daniel M. Czajkowsky, Ali Salanti, Sisse B. Ditlev, Zhifeng Shao, Ashfaq Ghumra, J. Alexandra Rowe, and Richard J. Pleass
J. Immunol., May 2010; 184: 4597 – 4603

IgM is an ancestral Ab class found in all jawed vertebrates, from sharks to mammals. This ancient ancestry is shared by malaria parasites (genus Plasmodium) that infect all classes of terrestrial vertebrates with whom they coevolved.

Open Access | Short Report: Evaluation of three PCR-based diagnostic assays for detecting mixed Plasmodium infection

April 8, 2010 - 07:42 -- Kabogo Ndegwa
T Mixson-Hayden, NW Lucchi, V Udhayakumar
BMC Res Notes (2010) 3: 88

The nested PCR method remains the method of choice for the detection of mixed malaria infections and especially of sub-clinical infections. 


Open Access | On the Diversity of Malaria Parasites in African Apes and the Origin of Plasmodium falciparum from Bonobos

February 23, 2010 - 12:13 -- Ingeborg van Schayk
Krief S, Escalante AA, Pacheco MA, Mugisha L, André C, et al.
PLoS Pathog 6(2): e1000765

Finally, our data and that of others indicated that chimpanzees and bonobos maintain malaria parasites, to which humans are susceptible, a factor of some relevance to the renewed efforts to eradicate malaria.


Open Access | Improved methods for magnetic purification of malaria parasites and haemozoin

January 19, 2010 - 15:40 -- Ingeborg van Schayk
Charles C Kim, Emily B Wilson, Joseph L DeRisi
Malaria Journal 2010, 9:17 (14 January 2010)

How to construct a cheap separation system for isolating haemozoin and infected red blood cells from malaria infected blood cultures using a magnet. The study is the first report of the effect of magnet strength and configuration on the efficiency of isolation of both haemozoin and iRBCs.

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