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malaria parasites

Short Reports: Five-minute Giemsa stain for rapid detection of malaria parasites in blood smears

December 20, 2010 - 12:30 -- Kabogo Ndegwa
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Author(s): 
M M Jager, J L Murk, R D Piqué, T A M Hekker, and C M J E Vandenbroucke-Grauls
Reference: 
Tropical Doctor, Volume 41, Number 1, Pp. 33-35

The Giemsa stain is used as the gold standard for the diagnosis of malaria on blood smears.

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Open Access | Impact of Schistosome Infection on Plasmodium falciparum Malariometric Indices and Immune Correlates in School Age Children in Burma Valley, Zimbabwe

November 16, 2010 - 10:13 -- Kabogo Ndegwa
Author(s): 
Davison T. Sangweme, Nicholas Midzi, Sekesai Zinyowera-Mutapuri, Takafira Mduluza, Marie Diener-West, Nirbhay Kumar
Reference: 
PLoS Negl Trop Dis 4(11): e882

A group of children aged 6–17 years was recruited and followed up for 12 months to study the impact of schistosome infection on malaria parasite prevalence, density, distribution and anemia.

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Open Access | Wolbachia Stimulates Immune Gene Expression and Inhibits Plasmodium Development in Anopheles gambiae

November 2, 2010 - 08:11 -- Kabogo Ndegwa
Author(s): 
Zakaria Kambris, Andrew M. Blagborough, Sofia B. Pinto, Marcus S. C. Blagrove, H. Charles J. Godfray, Robert E. Sinden, Steven P. Sinkins
Reference: 
Pathog 6(10): e1001143

The over-replicating wMelPop strain of the endosymbiont Wolbachia pipientis has recently been shown to be capable of inducing immune upregulation and inhibition of pathogen transmission in Aedes aegypti mosquitoes.

Open Access | Monitoring of malaria parasite resistance to chloroquine and sulphadoxine-pyrimethamine in the Solomon Islands by DNA microarray technology

October 11, 2010 - 08:15 -- Kabogo Ndegwa
Author(s): 
Ballif M, Hii J, Marfurt J, Crameri A, Fafale A, Felger I, Beck H, Genton B
Reference: 
Malaria Journal 2010, 9:270 (6 October 2010)

This work provides the first insight into drug resistance markers of P. falciparum in the SI. The obtained results indicated the presence of a very homogenous P. falciparum population circulating in the community.

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Open Access | Sequestration and Tissue Accumulation of Human Malaria Parasites: Can We Learn Anything from Rodent Models of Malaria?

October 6, 2010 - 08:09 -- Kabogo Ndegwa
Author(s): 
Blandine Franke-Fayard, Jannik Fonager, Anneke Braks, Shahid M. Khan, Chris J. Janse
Reference: 
PLoS Pathog 6(9): e1001032

The sequestration of Plasmodium falciparum–infected red blood cells (irbcs) in the microvasculature of organs is associated with severe disease; correspondingly, the molecular basis of irbc adherence is an active area of study.

Origin of the human malaria parasite Plasmodium falciparum in gorillas

September 24, 2010 - 13:08 -- Kabogo Ndegwa
Author(s): 
Weimin Liu, Yingying Li, Sabrina Locatelli, et al.
Reference: 
Nature 467, 420-425 (23 September 2010)

Plasmodium falciparum is the most prevalent and lethal of the malaria parasites infecting humans, yet the origin and evolutionary history of this important pathogen remain controversial.

Open Access | Naturally Occurring Triggers that Induce Apoptosis-Like Programmed Cell Death in Plasmodium berghei Ookinetes

September 17, 2010 - 10:06 -- Kabogo Ndegwa
Author(s): 
Medhat Ali, Ebtesam M. Al-Olayan, Steven Lewis, Holly Matthews, Hilary Hurd
Reference: 
PLoS ONE 5(9): e12634

Several protozoan parasites have been shown to undergo a form of programmed cell death that exhibits morphological features associated with metazoan apoptosis. These include the rodent malaria parasite, Plasmodium berghei.

TNF family members and malaria: Old observations, new insights and future directions Original

September 8, 2010 - 08:38 -- Kabogo Ndegwa
Author(s): 
Louise M. Randall, Christian R. Engwerda
Reference: 
Experimental Parasitology, Volume 126, Issue 3, November 2010, Pages 326-331

Tumor necrosis factor (TNF) has long been recognized to promote malaria parasite killing, but also to contribute to the development of severe malaria disease. The precise molecular mechanisms that influence these different outcomes in malaria patients are not well understood, but the virulence and drug-resistance phenotype of malaria parasites and the genetic background and age of patients are likely to be important determinants.

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Priority Paper Evaluation: How do malaria parasites activate dendritic cells?

August 24, 2010 - 12:15 -- Kabogo Ndegwa
Author(s): 
Tracey J Lamb, Michael P Schenk, Stephen M Todryk
Reference: 
Future Microbiology August 2010, Vol. 5, No. 8, Pages 1167-1171

The authors suggest that parasite DNA complexed with protein is the main trigger for activation of DCs in malaria-infected red blood cells.

Approximations for the hitchhiking effect caused by the evolution of antimalarial-drug resistance

July 19, 2010 - 13:40 -- Kabogo Ndegwa
Author(s): 
KA Schneider, Y Kim
Reference: 
Journal of Mathematical Biology, July 11, 2010

An analytically feasible, deterministic model for the spread of drug resistance among human malaria parasites, which incorporates all characteristics of the complex malaria-transmission cycle was introduced by Schneider and Kim (Theor. Popul Biol, 2010).

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