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malaria parasites

Open Access | Characterization and tissue-specific expression patterns of the Plasmodium chabaudi cir multigene family

September 28, 2011 - 08:04 -- Kabogo Ndegwa
Author(s): 
Petra Ebbinghaus, Jurgen Krucken
Reference: 
Malaria Journal 2011, 10:272 (19 September 2011)

The tissue-specific expression of cir mRNAs found in this study indicates correlation between expression of CIR antigens and distribution of parasites in inner organs.

Open Access | Hostile Takeover by Plasmodium: Reorganization of Parasite and Host Cell Membranes during Liver Stage Egress

September 7, 2011 - 07:06 -- Kabogo Ndegwa
Author(s): 
Stefanie Graewe, Kathleen E. Rankin, Christine Lehmann, Christina Deschermeier, Leonie Hecht, Ulrike Froehlke, Rebecca R. Stanway, Volker Heussler
Reference: 
PLoS Pathog 7(9): e1002224

The protozoan parasite Plasmodium is transmitted by female Anopheles mosquitoes and undergoes obligatory development within a parasitophorous vacuole in hepatocytes before it is released into the bloodstream.

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Open Access | What Do Human Parasites Do with a Chloroplast Anyway?

September 6, 2011 - 08:55 -- Kabogo Ndegwa
Author(s): 
Sethu C. Nair, Boris Striepen
Reference: 
PLoS Biol 9(8): e1001137

Apicomplexans are an important group of pathogens that include the causative agents of malaria, toxoplasmosis, and cryptosporidiosis.

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Falcipains and other cysteine proteases of malaria parasites.

June 14, 2011 - 13:33 -- Patrick Sampao
Author(s): 
Rosenthal PJ
Reference: 
Adv Exp Med Biol. 2011;712:30-48.

Gene disruption studies suggested that SERA-5 and SERA-6 are essential. activation of SERA-5 by a serine protease seems to be required for merozoite egress from the erythrocyte. New drugs for malaria are greatly needed and cysteine proteases represent potential drug targets.

Open Access | Inhibitory Effect of TNF-α on Malaria Pre-Erythrocytic Stage Development: Influence of Host Hepatocyte/Parasite Combinations

March 15, 2011 - 07:56 -- Kabogo Ndegwa
Author(s): 
Nadya Depinay, Jean Francois Franetich, Anne Charlotte Grüner, Marjorie Mauduit, Jean-Marc Chavatte, Adrian J. F. Luty, Geert-Jan van Gemert, Robert W. Sauerwein, Jean-Michel Siksik, Laurent Hannoun, Dominique Mazier, Georges Snounou, Laurent Rénia
Reference: 
PLoS ONE 6(3): e17464

Treatment TNF-α prevents the development of human and rodent malaria pre-erythrocytic stages through the activity of a mediator that remains to be identified.

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Open Access | Sex and Death: The Effects of Innate Immune Factors on the Sexual Reproduction of Malaria Parasites

March 11, 2011 - 08:29 -- Kabogo Ndegwa
Author(s): 
Ricardo S. Ramiro, João Alpedrinha, Lucy Carter, Andy Gardner, Sarah E. Reece
Reference: 
PLoS Pathog 7(3): e1001309

Malaria parasites must undergo a round of sexual reproduction in the blood meal of a mosquito vector to be transmitted between hosts.

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2-Acylamino-5-chlorobenzophenones with enhanced selectivity towards malaria parasites

March 9, 2011 - 08:21 -- Kabogo Ndegwa
Author(s): 
Swetlana, Heinrich Mirko, Altenkämper Benjamin, Bechem Johann, Perruchon Regina, Ortmann Hans-Martin, Dahse Yulin, Wang Michael, Lanzer Martin, Schlitzer
Reference: 
European Journal of Medicinal Chemistry, Volume 46, Issue 4, April 2011, Pages 1331-1342

Through the replacement of the 5-acylamino moiety by simple chlorine and further modifications of the 2-acylamino residue we could obtain inhibitors with improved selectivity towards malaria parasites combined with an acceptable reduction of antimalarial activity.

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The intradermal route for inoculation of sporozoites of rodent malaria parasites for immunological studies

January 18, 2011 - 06:56 -- Kabogo Ndegwa
Author(s): 
M. Inoue, R. L. Culleton
Reference: 
Parasite Immunology, Volume 33, Issue 2, pages 137–142, February 2011

Rodent malaria parasites are commonly used for investigations into the immunology of pre-erythrocytic stage malaria infection, as sporozoites can be easily produced in the laboratory.

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Plasmodium falciparum: Differential merozoite dose requirements for maximal production of various inflammatory cytokines

January 3, 2011 - 09:12 -- Kabogo Ndegwa
Author(s): 
Xianzhu Wu, Nagaraj M. Gowda, D. Channe Gowda
Reference: 
Experimental Parasitology, Volume 127, Issue 1, January 2011, Pages 202-207

The ligand specificity of TLRs and the details of signaling pathways that are activated by ligand–receptor engagements have been studied extensively.

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