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malaria parasites

Extrahepatic exoerythrocytic forms of rodent malaria parasites at the site of inoculation: Clearance after immunization, susceptibility to primaquine and contribution to blood stage infection

March 21, 2012 - 06:59 -- Patrick Sampao
Author(s): 
Tatiana Voza, Jessica L. Miller, Stefan H.I. Kappe and Photini Sinnis
Reference: 
Infection and Immunity, volume 80, issue 4

MalariaWorldOur studies demonstrate that skin exoerythrocytic stages are susceptible to destruction in immunized mice, suggesting that their aberrant location does not protect them from the host's adaptive immune response.

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Open Access | The complexities of malaria disease manifestations with a focus on asymptomatic malaria

February 7, 2012 - 08:23 -- Kabogo Ndegwa
Author(s): 
Laishram DD, Sutton PL, Nanda N, Sharma VL, Sobti RC, Carlton JM, Joshi H
Reference: 
Malaria Journal 2012, 11:29 (31 January 2012)

MalariaWorldMalaria is a serious parasitic disease in the developing world, causing high morbidity and mortality.

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Synthesis of purineN9-[2-hydroxy-3-O-(phosphonomethoxy)propyl] derivatives and their side-chain modified analogs as potential antimalarial agents

January 24, 2012 - 13:31 -- Kabogo Ndegwa
Author(s): 
Marcela Krečmerová, Martin Dračínský, Dana Hocková, Antonín Holý, Dianne T. Keough, Luke W. Guddat
Reference: 
Bioorganic & Medicinal Chemistry, Volume 20, Issue 3, 1 February 2012, Pages 1222–1230

MalariaWorld6-Oxopurine acyclic nucleoside phosphonates (ANPs) have been shown to be potent inhibitors of hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT), a key enzyme of the purine salvage pathway in human malarial parasites.

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Open Access | Plasticity in parasite phenotypes: evolutionary and ecological implications for disease

January 23, 2012 - 09:38 -- Kabogo Ndegwa
Author(s): 
Nicole Mideo , Sarah E Reece
Reference: 
Future Microbiology, January 2012, Vol. 7, No. 1, Pages 17-24

MalariaWorldPreventing disease is a major goal of applied bioscience and explaining variation in the harm caused by parasites, and their infectiousness, are major goals of evolutionary biology.

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Open Access | Plate-based transfection and culturing technique for genetic manipulation of Plasmodium falciparum

January 19, 2012 - 06:56 -- Kabogo Ndegwa
Author(s): 
Caro F, Miller MG, DeRisi JL
Reference: 
Malaria Journal 2012, 11:22 (18 January 2012)

MalariaWorldGenetic manipulation of malaria parasites remains an inefficient, time-consuming and resource-intensive process.

A Critical Role of Perinuclear Filamentous Actin in Spatial Repositioning and Mutually Exclusive Expression of Virulence Genes in Malaria Parasites

January 16, 2012 - 14:22 -- Patrick Sampao
Author(s): 
Qingfeng Zhang, Yufu Huang, Yilong Zhang, Xiaonan Fang, Aurelie Claes, Magalie Duchateau, Abdelkader Namane, Jose-Juan Lopez-Rubio, Weiqing Pan, Artur Scherf
Reference: 
Cell Host & Microbe, Volume 10, Issue 5, 17 November 2011, Pages 451–463

MalariaWorldWe show that var introns can control this process and that var intron addition relocalizes episomes from a random to a perinuclear position.

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Ontology-based malaria parasite stage and species identification from peripheral blood smear images

January 12, 2012 - 07:19 -- Kabogo Ndegwa
Author(s): 
Makkapati, Vishnu V; Rao, Raghuveer M
Reference: 
Engineering in Medicine and Biology Society,EMBC, 2011 Annual International Conference of the IEEE Aug. 30 2011-Sept. 3 2011

MalariaWorldThe diagnosis and treatment of malaria infection requires detecting the presence of the malaria parasite in the patient as well as identification of the parasite species.

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Open Access | Genome Comparison of Human and Non-Human Malaria Parasites Reveals Species Subset-Specific Genes Potentially Linked to Human Disease

December 28, 2011 - 06:55 -- Kabogo Ndegwa
Author(s): 
Christian Frech, Nansheng Chen
Reference: 
PLoS Comput Biol 7(12): e1002320

MalariaWorldGenes underlying important phenotypic differences between Plasmodium species, the causative agents of malaria, are frequently found in only a subset of species and cluster at dynamically evolving subtelomeric regions of chromosomes.

Open Access | clag9 Is Not Essential for PfEMP1 Surface Expression in Non-Cytoadherent Plasmodium falciparum Parasites with a Chromosome 9 Deletion

December 28, 2011 - 06:53 -- Kabogo Ndegwa
Author(s): 
Adéla Nacer, Emeric Roux, Sébastien Pomel, Christine Scheidig-Benatar, Hiroshi Sakamoto, Frank Lafont, Artur Scherf, Denise Mattei
Reference: 
PLoS ONE 6(12): e29039

MalariaWorldOur data show the surface expression of non-functional PfEMP1 in D10 strongly indicating that genes other than clag9 deleted from chromosome 9 are involved in this virulence process possibly via post-translational modifications.

Molecular interactions and signaling mechanisms during erythrocyte invasion by malaria parasites

October 19, 2011 - 09:09 -- Patrick Sampao
Author(s): 
Deepak Gaur, Chetan E Chitnis
Reference: 
Current Opinion in Microbiology, Volume 14, Issue 4, August 2011, Pages 422-428

MalariaWorldHere, we review recent studies on interactions between erythrocyte binding antigens (EBA) and PfRH proteins from the parasite and erythrocyte receptors involved in invasion.

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