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malaria parasites

Genetic mapping of fitness determinants across the malaria parasite Plasmodium falciparum life cycle

October 28, 2019 - 16:20 -- Open Access
Author(s): 
Xue Li, Sudhir Kumar, Ashley M. Vaughan, et al.
Reference: 
PLoS Genet 15(10): e1008453

Determining the genetic basis of fitness is central to understanding evolution and transmission of microbial pathogens.

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Review: Do malaria parasites manipulate mosquitoes?

October 23, 2012 - 10:52 -- Patrick Sampao
Author(s): 
Lauren J. Cator, Penelope A. Lynch, Andrew F. Read, Matthew B. Thomas
Reference: 
Trends in Parasitology, Volume 28, Issue 11, November 2012, Pages 466-470

MalariaWorldWe review and discuss the current evidence for manipulation, explore its potential significance for malaria transmission, and suggest ways to move this hypothesis forward from theory to potential application in malaria control.

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Not Open Access |Genomic Sequencing of Plasmodium falciparum Malaria Parasites from Senegal Reveals the Demographic History of the Population

October 17, 2012 - 16:08 -- Patrick Sampao
Author(s): 
Hsiao-Han Chang, Daniel J. Park, Daniel L. Hartl, et al.
Reference: 
Mol Biol Evol (2012) 29 (11): 3427-3439.

MalariaWorldWe show that there is no significant population structure among these Senegal sampling sites. By fitting demographic models to the synonymous allele-frequency spectrum, we also estimated a major 60-fold population expansion of this parasite population ∼20,000–40,000 years ago.

SNP Genotyping Identifies New Signatures of Selection in a Deep Sample of West African Plasmodium falciparum Malaria Parasites

October 17, 2012 - 16:04 -- Patrick Sampao
Author(s): 
Alfred Amambua-Ngwa, Daniel J. Park, Stephen F. Schaffner, et al.
Reference: 
Molecular Biology and Evolution, Volume 29, Issue 11 Pp. 3249-3253.

MalariaWorldWe discuss the value of deep population-specific genomic analyses for identifying selection signals within sampled endemic populations of parasites, which may correspond to local selection pressures such as distinctive therapeutic regimes or mosquito vectors.

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Letter: Novel Vectors of Malaria Parasites in the Western Highlands of Kenya

August 23, 2012 - 15:05 -- Patrick Sampao
Author(s): 
Jennifer Stevenson, Brandyce St. Laurent, Neil F. Lobo, Mary K. Cooke, Samuel C. Kahindi, Robin M. Oriango, Ralph E. Harbach, Jonathan Cox, and Chris Drakeley
Reference: 
Emerging Infectious Diseases, Volume 18, Number 9—September 2012

MalariaWorldWe evaluated indoor and outdoor trapping methods for anopheline mosquitoes in Bigege village, in Kisii Central District in the highlands of western Kenya, which are prone to periodic malaria epidemics.

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Not Open Access | The Plasmodium Apicoplast Genome: Conserved Structure and Close Relationship of P. ovale to Rodent Malaria Parasites

August 22, 2012 - 14:36 -- Patrick Sampao
Author(s): 
Nobuko Arisue, Tetsuo Hashimoto, Hideya Mitsui, Nirianne M.Q. Palacpac, Akira Kaneko, Satoru Kawai, Masami Hasegawa, Kazuyuki Tanabe and Toshihiro Horii
Reference: 
Mol Biol Evol (2012) 29 (9): 2095-2099

MalariaWorldHere, we obtained the near-complete apicoplast genome sequences from eight Plasmodium species that infect a wide variety of vertebrate hosts and performed structural and phylogenetic analyses.

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Not Open Access | Generation of second messengers in Plasmodium

July 13, 2012 - 09:09 -- Patrick Sampao
Author(s): 
Alexandre Budu, Célia R.S. Garcia
Reference: 
Microbes and Infection, Volume 14, Issue 10, August 2012, Pages 787-795

MalariaWorldThe scope of this review is to discuss external stimuli in the parasite life cycle and the upstream machinery responsible for translating them into intracellular responses, focussing particularly on the calcium signalling pathway.

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PCR detection of malaria parasites in desiccated Anopheles mosquitoes is uninhibited by storage time and temperature

June 14, 2012 - 07:48 -- Patrick Sampao
Author(s): 
Rider MA, Byrd BD, Keating J, Wesson DM, Caillouët KA
Reference: 
Malaria Journal 2012, 11:193 (10 June 2012)

MalariaWorldThis study investigated the effect of storage time and temperature on the ability to detect Plasmodium parasites in desiccated Anopheles mosquitoes by real-time polymerase chain reaction (PCR).

Open Access | Intracellular proteolysis of kininogen by malaria parasites promotes release of active kinins

May 10, 2012 - 10:00 -- Patrick Sampao
Author(s): 
Bagnaresi P, de Barros NM, Assis DM, Melo PM, Fonseca RG, Juliano MA, Pesquero JB, Juliano L, Rosenthal PJ, Carmona AK, Gazarini ML
Reference: 
Malaria Journal 2012, 11:156 (7 May 2012)

MalariaWorldIn the present work, it was demonstrated by mass spectrometry analysis that Plasmodium parasites (Plasmodium chabaudi and Plasmodium falciparum) internalize and process plasma kininogen, thereby releasing vasoactive kinins (Lys-BK, BK and des-Arg9-BK) that may mediate haemodynamic alterations during acute malaria.

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