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Plasmodium yoelii

Allicin enhances host pro-inflammatory immune responses and protects against acute murine malaria infection

August 9, 2012 - 14:21 -- Kabogo Ndegwa
Author(s): 
Feng Y, Zhu X, Wang Q, Jiang Y, Shang H, Cui L, Cao Y
Reference: 
Malaria Journal 2012, 11:268 (8 August 2012)

MalariaWorldAllicin could partially protect host against P. yoelii 17XL through enhancement of the host innate and adaptive immune responses.

Medical Condition: 

Remarkable stability in patterns of blood-stage gene expression during episodes of non-lethal Plasmodium yoelii malaria

August 8, 2012 - 07:11 -- Kabogo Ndegwa
Author(s): 
Cernetich-Ott A, Daly TM, Vaidya AB, Bergman LW, Burns JM
Reference: 
Malaria Journal 2012, 11:265 (6 August 2012)

MalariaWorldTaken together, these results indicate that 1) P. yoelii gene expression remains stable in the presence of a changing host environment, and 2) concurrent expression of a large number of the polymorphic yir and pyst-a genes, rather than differential expression in response to specific host factors, may in itself limit the effectiveness of host immune responses.

NOT Open Access | Supplement of L-Arg improves protective immunity during early-stage Plasmodium yoelii 17XL infection

August 8, 2012 - 06:53 -- Kabogo Ndegwa
Author(s): 
X. Zhu, Y. Pan, Y. Li, L. Cui, Y. Cao
Reference: 
Parasite Immunology, Volume 34, Issue 8-9, pages 412–420, August/September 2012

MalariaWorldL-arginine (L-Arg), the precursor of nitric oxide (NO), plays multiple important roles in nutrient metabolism and immune regulation.

Medical Condition: 

NOT Open Access | The course of a primary infection of Plasmodium yoelii 17XL in both 129S1 and IFN-y receptor-deficient mice

July 26, 2012 - 11:55 -- Kabogo Ndegwa
Author(s): 
Akira Ishih, Toshi Nagata & Fumie Kobayashi
Reference: 
Parasitology Research, Volume 111, Number 2 (2012), 593-600

MalariaWorldIn the present study, we found that 129S1 mice are resistant to the infection with Plasmodium yoelii 17XL, which is highly virulent and causes lethal infection in various strains of mice.

Medical Condition: 

NOT Open Access | Efficient control of Plasmodium yoelii infection in BALB/c and C57BL/6 mice with pre-existing Strongyloides ratti infection

June 14, 2012 - 07:39 -- Kabogo Ndegwa
Author(s): 
J. Kolbaum, M.-L. Eschbach, C. Steeg, T. Jacobs, B. Fleischer and M. Breloer
Reference: 
Parasite Immunology, Volume 34, Issue 7, pages 388–393, July 2012

MalariaWorldAbout 225 million malaria cases have been reported worldwide in 2009, and one-third of the world’s population is infected with parasitic helminths.

Medical Condition: 

NOT Open Access | Strong Impact of CD4+Foxp3+ Regulatory T Cells and Limited Effect of T Cell-Derived IL-10 on Pathogen Clearance during Plasmodium yoelii Infection

May 23, 2012 - 10:12 -- Kabogo Ndegwa
Author(s): 
Simone Abel, Nadja Lückheide, Astrid M. Westendorf, Robert Geffers, Axel Roers, Werner Müller, Tim Sparwasser, Kai Matuschewski, Jan Buer, and Wiebke Hansen
Reference: 
The Journal of Immunology June 1, 2012 vol. 188 no. 11 5467-5477

MalariaWorldIt is well established that CD4+CD25+Foxp3+ regulatory T cells (Tregs) play a crucial role in the course of different infectious diseases.

Medical Condition: 

Macrophage migration inhibitory factor homolog from Plasmodium yoelii modulates monocyte recruitment and activation in spleen during infection

April 27, 2012 - 09:35 -- Kabogo Ndegwa
Author(s): 
Yanhui Zhang, Kazutoyo Miura, Jian Li, Gregory Tullo, Feng Zhu, Lingxian Hong, Tianlong Lin, Xin-zhuan Su & Carole Long
Reference: 
Parasitology Research, Volume 110, Number 5 (2012), 1755-1763,

MalariaWorldMacrophage migration inhibitory factor (MIF) has been shown to be involved in the pathogenesis of severe malaria.

Medical Condition: 

Open Access | Plasmodium yoelii blood-stage primes macrophage-mediated innate immune response through modulation of toll-like receptor signalling

April 4, 2012 - 14:12 -- Kabogo Ndegwa
Author(s): 
Fu Y, Ding Y, Zhou T, Fu X, Xu W
Reference: 
Malaria Journal 2012, 11:104 (1 April 2012)

MalariaWorldBoth P. yoelii 17XL and 17XNL strains could enhance the response of peritoneal macrophages to pRBC lysate and TLR agonists, through up-regulating the expression of TLR2 and intracellular signalling molecules MyD88, IRAK-1, and TRAF-6.

Medical Condition: 

A new malaria antigen produces partial protection against Plasmodium yoelii challenge

March 22, 2012 - 13:06 -- Kabogo Ndegwa
Author(s): 
Yanhui Zhang, Yanwei Qi, Jian Li, Shengfa Liu, Lingxian Hong, Tianlong Lin, Carole Long & Xin-zhuan Su
Reference: 
Parasitology Research, Volume 110, Number 4, 1337-1345

MalariaWorldOf all the parasitic diseases, malaria is the number one killer.

Person: 

Open Access | Extracellular ATP triggers proteolysis and cytosolic Ca2+ rise in Plasmodium berghei and Plasmodium yoelii malaria parasites

March 22, 2012 - 06:58 -- Kabogo Ndegwa
Author(s): 
Nogueira da Cruz L, Juliano M, Budu A, Juliano L, Holder AA, Blackman MJ, Garcia CR
Reference: 
Malaria Journal 2012, 11:69 (15 March 2012)

MalariaWorldThe data clearly show that purinergic signalling modulates P. berghei protease(s) activity and that MSP1 is one target in this pathway.

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