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antimalarial resistance

Synthesis, Structure-Activity Relationship, and Mode-of-Action Studies of Antimalarial Reversed Chloroquine Compounds

August 10, 2010 - 08:20 -- Kabogo Ndegwa
Author(s): 
SJ Burgess, JX Kelly, S Shomloo, S Wittlin, R Brun, K Liebmann, DH Peyton
Reference: 
J. Med. Chem. August 4, 2010

We have previously shown that a "reversed chloroquine (RCQ)" molecule, composed of a chloroquine-like moiety and a resistance reversal-like moiety, can overcome chloroquine resistance in P. falciparum

Open Access | Heterogeneity in malaria exposure and vaccine response: implications for the interpretation of vaccine efficacy trials

March 23, 2010 - 21:10 -- Ingeborg van Schayk
Author(s): 
Michael T White, Jamie T Griffin, Chris J Drakeley, Azra C Ghani
Reference: 
Malaria Journal 2010, 9:82 (23 March 2010)

Phase III trials of the malaria vaccine, RTS,S, are now underway across multiple sites of varying transmission intensity in Africa. Heterogeneity in exposure, vaccine response and waning of efficacy may bias estimates of vaccine efficacy.
 

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Longitudinal Survey of Plasmodium falciparum Infection in Vietnam: Characteristics of Antimalarial Resistance and Their Associated Factors

January 14, 2010 - 17:54 -- Kabogo Ndegwa
Author(s): 
Rie Isozumi, Haruki Uemura, Le Duc Dao, Truong Van Hanh, Nguyen Duc Giang, Ha Viet Vien, Bui Quang Phuc, Nguyen Van Tuan, and Shusuke Nakazawa
Reference: 
Journal of Clinical Microbiology, January 2010, p. 70-77, Vol. 48, No. 1

Defining the trend in genotypes related to drug resistance is essential for the control of malaria in Vietnam.

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