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antigens

A highly sensitive solid-phase radioimmunoassay for the assay of Plasmodium falciparum antigens and antibodies

January 21, 2011 - 08:30 -- Patrick Sampao
Author(s): 
H. Avraham, J. Golenser, Y. Gazitt, D.T. Spira, D. Sulitzeanu
Reference: 
Journal of Immunological Methods, Volume 53, Issue 1, 27 August 1982, Pages 61-68

A highly sensitive radioimmunoassay for detection of P. falciparum antibodies and antigens is described.

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Production of IFN-γ by CD4+ T cells in response to malaria antigens is IL-2 dependent

December 16, 2010 - 09:16 -- Patrick Sampao
Author(s): 
Daisuke Kimura, Mana Miyakoda, Kiri Honma, Yoshisada Shibata, Masao Yuda, Yasuo Chinzei and Katsuyuki Yui
Reference: 
Int. Immunol. (2010) 22 (12): 941-952.

We examined the regulation of CD4+ T-cell cytokine responses during infection with Plasmodium berghei ANKA (PbA).

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Open Access | Oral Presentation: Variant surface antigens in cerebral malaria: distinct from others and similar to each other?

November 4, 2010 - 07:24 -- Patrick Sampao
Author(s): 
Agnès Aubouy, Nabila Kheliouen, Philippe Deloron, et al.
Reference: 
Malaria Journal 2010, 9(Suppl 2):O2 (20 October 2010)

In distinct malaria clinical presentations, as placental malaria, specific antibody response against VSA provides protection.

Open Access | Surface Co-Expression of Two Different PfEMP1 Antigens on Single Plasmodium falciparum-Infected Erythrocytes Facilitates Binding to ICAM1 and PECAM1

September 9, 2010 - 12:07 -- Patrick Sampao
Author(s): 
Louise J., Dominique C., et al.
Reference: 
PLoS Pathogens Volume 6 Issue 9 September 02, 2010

These new results on PfEMP1 antigen expression indicate that a re-evaluation of the molecular mechanisms involved in P. falciparum adhesion and of the accepted paradigm of absolutely mutually exclusive var gene transcription is required.

Open Access | Plasmodium falciparum parasites causing cerebral malaria share variant surface antigens, but are they specific?

July 29, 2010 - 10:32 -- Kabogo Ndegwa
Author(s): 
Kheliouen N, Viwami F, Lalya F, Tuikue-Ndam N, Eboumbou Moukoko EC, Rogier C, Deloron P, Aubouy A
Reference: 
Malaria Journal 2010, 9:220 (27 July 2010)

In conclusion, this study suggests the existence of serologically distinct VSACM and VSAUM. CM isolates were shown to share common epitopes. Specific antibody response to VSAUM was predominant, suggesting a relative low diversity of VSAUM in the study area.

Bottleneck effects on vaccine-candidate antigen diversity of malaria parasites in Thailand

March 31, 2010 - 11:26 -- Patrick Sampao
Author(s): 
Somchai Jongwutiwes, Chaturong Putaporntip, Austin L. Hughes
Reference: 
Vaccine, Volume 28, Issue 18, 19 April 2010, Pages 3112-3117

These results suggest a two-pronged strategy for malaria eradication: (1) strenuous non-vaccine control measures that will cause a severe population bottleneck in the parasite; and (2) a subsequent local vaccine focused on one or a few locally occurring alleles at antigen-encoding loci.

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Acquired immune response to defined Plasmodium vivax antigens in individuals residing in northern India

February 25, 2010 - 21:59 -- Kabogo Ndegwa
Author(s): 
Ratanesh K. Seth, Ajaz A. Bhat, Donthamsetty N. Rao, Sukla Biswas
Reference: 
Microbes and Infection, Volume 12, Issue 3, March 2010, Pages 199-206

In this investigation, we evaluated the naturally acquired immune response to Plasmodium vivax stage-specific antigens in individuals of different age groups belonging to malaria endemic areas of northern India.

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Open Access | Acquisition of antibody isotypes against Plasmodium falciparum blood stage antigens in a birth cohort

January 14, 2010 - 11:31 -- Ingeborg van Schayk
Author(s): 
N. Duah, D. Miles, H. Whittle, D. Conway
Reference: 
Parasite Immunology, Volume 32 Issue 2, Pages 125 - 13

Information on the period during which infants lose their maternally derived antibodies to malaria and begin to acquire naturally their own immune responses against parasite antigens is crucial for understanding when malaria vaccines may be best administered.

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