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Open Access | VEGF Promotes Malaria-Associated Acute Lung Injury in Mice

May 27, 2010 - 07:46 -- Kabogo Ndegwa
Sabrina Epiphanio, Marta G. Campos, Ana Pamplona, Daniel Carapau, Ana C. Pena, Ricardo Ataíde, Carla A. A. Monteiro, Nuno Félix, Artur Costa-Silva, Claudio R. F. Marinho, Sérgio Dias, Maria M. Mota
PLoS Pathog 6(5): e1000916.

The spectrum of the clinical presentation and severity of malaria infections is broad, ranging from uncomplicated febrile illness to severe forms of disease such as cerebral malaria (CM), acute lung injury (ALI), acute respiratory distress syndrome (ARDS), pregnancy-associated malaria (PAM) or severe anemia (SA).

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Brief report: Elevated Levels of Vascular Endothelial Growth Factor (VEGF) and Soluble Vascular Endothelial Growth Factor Receptor (VEGFR)-2 in Human Malaria

January 14, 2010 - 10:48 -- Ingeborg van Schayk
Takahisa Furuta, Mikio Kimura, AND Naohiro Watanabe
Am J Trop Med Hyg 2010;82 136-139

This is the first report to suggest that the interaction of VEGF and sVEGFR-2 is involved in the host immune response to malarial infection and that malarial parasites induce VEGF secretion from human mast cells.

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