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Open Access | Combination of measures distinguishes pre-miRNAs from other stem-loops in the genome of the newly sequenced Anopheles darlingi

September 30, 2010 - 08:57 -- Patrick Sampao
Mendes ND, Freitas AT, Vasconcelos AT, Sagot M
BMC Genomics 2010, 11:529 (29 September 2010)

We show that there is a strong bias amongst annotated pre-miRNAs towards robust stem-loops in the genomes of Drosophila melanogaster and Anopheles gambiae and we propose a scoring scheme for precursor candidates which combines four robustness measures.

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Open Access | Long- and Short-Term Selective Forces on Malaria Parasite Genomes

September 13, 2010 - 13:03 -- Kabogo Ndegwa
Sanne Nygaard, Alexander Braunstein, Daniel C. Jeffares,.et al
PLoS Genet 6(9): e1001099

Plasmodium parasites, the causal agents of malaria, result in more than 1 million deaths annually. Plasmodium are unicellular eukaryotes with small ~23 Mb genomes encoding ~5200 protein-coding genes.

Open Access | Malaria parasite genome scan: insights into antimalarial resistance

July 12, 2010 - 14:29 -- Kabogo Ndegwa
Bhavna Gupta, Gauri Awasthi and Aparup Das
Parasitology Research, Volume 107, Number 2 / July, 2010

Genome scan and genotype-phenotype association study offer excellent opportunities to unearth drug/vaccine targets in human pathogens including malaria parasites.

Open Access | Heritability of the Human Infectious Reservoir of Malaria Parasites

July 2, 2010 - 11:11 -- Kabogo Ndegwa
Yaye Ramatoulaye Lawaly, Anavaj Sakuntabhai, Rick Paul, et al
PLoS ONE 5(6): e11358

The existence of a significant human genetic contribution to gametocyte prevalence in asymptomatic infections suggests that candidate gene and genome wide association approaches may be usefully applied to explore the underlying human genetics.


Open Access | Geographical origin of Plasmodium vivax in the Republic of Korea: haplotype network analysis based on the parasite's mitochondrial genome

June 29, 2010 - 09:54 -- Kabogo Ndegwa
Iwagami M, Hwang S, Fukumoto M, Hayakawa T, Tanabe K, Kim S, Kho W, Kano S
Malaria Journal 2010, 9:184 (25 June 2010)

Although the direct introduction of the two P. vivax populations in South Korea were thought to have been from North Korea, the results of this analysis suggest the genealogical origin to be the two different populations in southern China.


Open Access | Genome Wide Analysis of Inbred Mouse Lines Identifies a Locus Containing Ppar-γ as Contributing to Enhanced Malaria Survival

June 4, 2010 - 07:58 -- Kabogo Ndegwa
Selina E. R. Bopp, Vandana Ramachandran, Kerstin Henson, Angelina Luzader, Merle Lindstrom, Muriel Spooner, Brian M. Steffy, Oscar Suzuki, Chris Janse, Andrew P. Waters, Yingyao Zhou, Tim Wiltshire, Elizabeth A. Winzeler
PLoS ONE 5(5): e10903.

The genetic background of a patient determines in part if a person develops a mild form of malaria and recovers, or develops a severe form and dies. We have used a mouse model to detect genes involved in the resistance or susceptibility to Plasmodium berghei malaria infection.


Open Access | Defining species specific genome differences in malaria parasites

March 3, 2010 - 12:35 -- Ingeborg van Schayk
Liew KJ, Hu G, Bozdech Z, Preiser PR
BMC Genomics 2010, 11:128 (23 February 2010)

To improve the current annotation and gene identification status of the draft genomes of P. berghei, P. chabaudi and P. yoelii, we performed genome-wide comparisons between these three species.

Nucleosome landscape and control of transcription in the human malaria parasite

January 10, 2010 - 15:26 -- Ingeborg van Schayk
Nadia Ponts, Elena Y. Harris, Jacques Prudhomme, Ivan Wick, Colleen Eckhardt-Ludka, Glenn R. Hicks, Gary Hardiman, Stefano Lonardi, and Karine G. Le Roch
Genome Res. published 6 January 2010

Our results demonstrate that the processes driving gene expression in Plasmodium challenge the classical eukaryotic model of transcriptional regulation occurring mostly at the transcription initiation level.

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