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chloroquine-resistant

NOT Open Access | Synthesis and in vitro evaluation of new chloroquine-chalcone hybrids against chloroquine-resistant strain of Plasmodium falciparum

August 16, 2012 - 08:18 -- Kabogo Ndegwa
Author(s): 
Koneni V. Sashidhara, Srinivasa Rao Avula, Gopala Reddy Palnati, Shiv Vardan Singh, Kumkum Srivastava, Sunil K. Puri, J.K. Saxena
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 22, Issue 17, 1 September 2012, Pages 5455–5459

MalariaWorldThe control of malaria has been complicated with increasing resistance of malarial parasite against existing antimalarials.

Karavilagenin C derivatives as antimalarials

January 4, 2011 - 07:08 -- Kabogo Ndegwa
Author(s): 
Cátia Ramalhete, Dinora Lopes, Joseph Molnár, Silva Mulhovo, Virgílio E. Rosário, Maria-José U. Ferreira
Reference: 
Bioorganic & Medicinal Chemistry, Volume 19, Issue 1, 1 January 2011, Pages 330-338

Karavilagenin C (1), a cucurbitane-type triterpenoid, previously isolated from the aerial parts of Momordica balsamina, was acylated with different alkanoyl, aroyl and cinnamoyl chlorides/anydrides, yielding ten new mono or diesters, karavoates F (7) and H-P (8–16).

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In Vitro Activity of Pyronaridine against Multidrug-Resistant Plasmodium falciparum and Plasmodium vivax

November 19, 2010 - 11:38 -- Kabogo Ndegwa
Author(s): 
R. N. Price, J. Marfurt, F. Chalfein, E. Kenangalem, K. A. Piera, E. Tjitra, N. M. Anstey, and B. Russell
Reference: 
Antimicrobial Agents and Chemotherapy, December 2010, p. 5146-5150, Vol. 54, No. 12

Pyronaridine, a Mannich base antimalarial, has demonstrated high in vivo and in vitro efficacy against chloroquine-resistant Plasmodium falciparum.

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Open Access | In vitro antimalarial activity of traditionally used Western Ghats plants from India and their interactions with chloroquine against chloroquine-resistant Plasmodium falciparum

November 19, 2010 - 11:22 -- Kabogo Ndegwa
Author(s): 
Kuppusamy Chenniappan & Murugan Kadarkarai
Reference: 
Parasitology Research Volume 107, Number 6, Pages 1351-1364

Malaria is a major global public health problem, and the alarming spread of drug resistance and limited number of effective drugs now available underline how important it is to discover new antimalarial compounds.

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Selective accumulation of a novel antimalarial rhodacyanine derivative, SSJ-127, in an organelle of Plasmodium berghei

November 3, 2010 - 09:59 -- Kabogo Ndegwa
Author(s): 
Mayumi Ikegami-Kawai, Chika Arai, Yuko Ogawa, Ryohei Yanoshita, Masataka Ihara
Reference: 
Bioorganic & Medicinal Chemistry, Volume 18, Issue 22, 15 November 2010, Pages 7804-7808

SSJ-127, a novel antimalarial rhodacyanine derivative, has shown potent antimalarial activity against chloroquine-resistant Plasmodium strains in vitro and subcutaneous administration of SSJ-127 results in a complete cure of a mouse malaria model. SSJ-127 was detected by fluorescence microscopy in the mouse malaria parasites Plasmodium berghei after exposure of infected red blood cells to the compound in vitro and in vivo.

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3-Alkylthio-1,2,4-triazine dimers with potent antimalarial activity

September 23, 2010 - 09:10 -- Kabogo Ndegwa
Author(s): 
Kung Ban, Sandra Duffy, Yelena Khakham, Vicky M. Avery, Andrew Hughes, Oliver Montagnat, Kasiram Katneni, Eileen Ryan, Jonathan B. Baell
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 20, Issue 20, 15 October 2010, Pages 6024-6029

We report on the discovery of 3-alkylthio-1,2,4-triazine dimers that are potently toxic to Plasmodium falciparum, with single digit nanomolar activity, and up to several thousand-fold lower toxicity to mammalian cells.

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Open Access | In vitro and in vivo anti-malarial activity of Boerhavia elegans and Solanum surattense

May 13, 2010 - 14:27 -- Kabogo Ndegwa
Author(s): 
Ramazani A, Zakeri S, Sardari S, Khodakarim N, Djadid N
Reference: 
Malaria Journal 2010, 9:124 (12 May 2010)

Anti-plasmodial activities of extracts of B. elegans and S. surattense are reported for the first time.

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Imported Chloroquine-Resistant Plasmodium vivax in Singapore: Case Report and Literature Review

January 10, 2010 - 15:15 -- Ingeborg van Schayk
Author(s): 
Poh Lian Lim, Ying Juan Mok, David C. Lye, Yee Sin Leo
Reference: 
Journal of Travel Medicine, Volume 17 Issue 1, Pages 69 - 71

We report a 58-year-old business traveler who returned from Indonesia and experienced relapse due to CRPV. The epidemiology and diagnostic challenges of CRPV for travel medicine clinicians are reviewed.

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