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anopheles gambiae

Malaria transmission in two rural communities in the forest zone of Ghana

May 25, 2011 - 07:53 -- Kabogo Ndegwa
Ayimbire Abonuusum, Kofi Owusu-Daako, Egbert Tannich, Jürgen May, Rolf Garms and Thomas Kruppa
Parasitology Research, Volume 108, Number 6, 1465-1471

Malaria transmission was assessed in two rural communities, Kona and Afamanaso in Sekyere South district, Ashanti Region, in the forest zone of Ghana to provide baseline data for ongoing clinical studies and the evaluation of the effect of interventions.


Open Access | Wolbachia Infections Are Virulent and Inhibit the Human Malaria Parasite Plasmodium Falciparum in Anopheles Gambiae

May 24, 2011 - 10:06 -- Kabogo Ndegwa
Grant L. Hughes, Ryuichi Koga, Ping Xue, Takema Fukatsu, Jason L. Rasgon
PLoS Pathog 7(5): e1002043

Endosymbiotic Wolbachia bacteria are potent modulators of pathogen infection and transmission in multiple naturally and artificially infected insect species, including important vectors of human pathogens.

Open Access | Comparative Genomic Analysis of Chitinase and Chitinase-Like Genes in the African Malaria Mosquito (Anopheles gambiae)

May 24, 2011 - 08:06 -- Kabogo Ndegwa
Jianzhen Zhang, Xin Zhang, Yasuyuki Arakane, Subbaratnam Muthukrishnan, Karl J. Kramer, Enbo Ma, Kun Yan Zhu
PLoS ONE 6(5): e19899

Chitinase is an important enzyme responsible for chitin metabolism in a wide range of organisms including bacteria, yeasts and other fungi, nematodes and arthropods.

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Open Access | Crystal structure of a novel type of odorant binding protein from Anopheles gambiae, belonging to the C+ class

May 13, 2011 - 08:34 -- Patrick Sampao
Amandine Lagarde, Silvia Spinelli, Huili Qiao, Mariella Tegoni, Paolo Pelosi and Christian Cambillau
Biochem. J. (2011)

Here, we report the first 3D structure of a member of the OBP C+ class, AgamOBP47, which has a longer sequence than classical OBPs and contains 6 disulphide bridges.

A synthetic homing endonuclease-based gene drive system in the human malaria mosquito

May 13, 2011 - 08:03 -- Kabogo Ndegwa
Nikolai Windbichler, Miriam Menichelli, Hui Li, Andrea Crisanti, et al.
Nature, Volume: 473, Pages: 212–215 Date published: (12 May 2011)

Genetic methods of manipulating or eradicating disease vector populations have long been discussed as an attractive alternative to existing control measures because of their potential advantages in terms of effectiveness and species specificity1, 2, 3.

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Open Access | Structure-Function Analysis of the Anopheles gambiae LRIM1/APL1C Complex and its Interaction with Complement C3-Like Protein TEP1

May 4, 2011 - 06:37 -- Kabogo Ndegwa
Michael Povelones, Leanna M. Upton, Katarzyna A. Sala, George K. Christophides
PLoS Pathog 7(4): e1002023

Malaria threatens half the world's population and exacts a devastating human toll.

Cooperative interactions between odorant-binding proteins of Anopheles gambiae

April 27, 2011 - 06:39 -- Kabogo Ndegwa
Huili Qiao, Xiaoli He, Danuta Schymura, Liping Ban, Linda Field, Francesca Romana Dani, Elena Michelucci, Beniamino Caputo, Alessandra della Torre, Kostas Iatrou, Jing-Jiang Zhou, Jürgen Krieger & Paolo Pelosi
Cellular and Molecular Life Sciences, Volume 68, Number 10, 1799-1813

To understand olfactory discrimination in Anopheles gambiae, we made six purified recombinant OBPs and investigated their ligand-binding properties.

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Mosquito age and susceptibility to insecticides

April 26, 2011 - 14:03 -- Patrick Sampao
Shavanthi Rajatileka, Joseph Burhani, Hilary Ranson
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 105, Issue 5, May 2011, Pages 247-253

This study investigated the impact of senescence and blood feeding on insecticide induced mortality in six different mosquito populations and found higher mortality after insecticide exposure in older mosquitoes in three populations of Aedes aegypti and two Anopheles gambiae populations.

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Energy metabolism affects susceptibility of Anopheles gambiae mosquitoes to Plasmodium infection

April 14, 2011 - 13:01 -- Kabogo Ndegwa
Jose Henrique M. Oliveira, Renata L.S. Gonçalves, Giselle A. Oliveira, Pedro L. Oliveira, Marcus F. Oliveira and Carolina Barillas-Mury
Insect Biochemistry and Molecular Biology, Volume 41, Issue 6, June 2011, Pages 349-355

Previous studies showed that Anopheles gambiae L3-5 females, which are refractory (R) to Plasmodium infection, express higher levels of genes involved in redox-metabolism and mitochondrial respiration than susceptible (S) G3 females.

Open Access | Aquaporin water channel AgAQP1 in the malaria vector mosquito Anopheles gambiae during blood feeding and humidity adaptation

April 14, 2011 - 11:44 -- Kabogo Ndegwa
Kun Liu, Hitoshi Tsujimoto, Sung-Jae Cha, Peter Agre and Jason L. Rasgon
PNAS April 12, 2011 vol. 108 no. 15 6062-6066

Altered patterns of malaria endemicity reflect, in part, changes in feeding behavior and climate adaptation of mosquito vectors.

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