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anopheles gambiae

Variation in metabolic rate of Anopheles gambiae and A. arabiensis in a Sahelian village.

July 6, 2011 - 13:05 -- Patrick Sampao
Huestis DL, Yaro AS, Traoré AI, Adamou A, Kassogué Y, Diallo M, Timbiné S, Dao A, Lehmann T.
J Exp Biol. 2011 Jul 15;214(Pt 14):2345-53.

To examine possible physiological divergence between these taxa, we measured metabolic rates of mosquitoes during the wet season in a Sahelian village in Mali. To our knowledge, this study provides the first measurements of metabolic rates of A. gambiae and A. arabiensis in the field.

Medical Condition: 

Identification and characterization of a novel chitinase-like gene cluster (AgCht5) possibly derived from tandem duplications in the African malaria mosquito, Anopheles gambiae

June 29, 2011 - 06:34 -- Kabogo Ndegwa
Jianzhen Zhang, Xin Zhang, Yasuyuki Arakane, Subbaratnam Muthukrishnan, Karl J. Kramer, Enbo Ma, Kun Yan Zhu
Insect Biochemistry and Molecular Biology, Volume 41, Issue 8, August 2011, Pages 521-528

Insect chitinase 5 (Cht5), a well-characterized enzyme found in the molting fluid and/or integument, is classified as a group I chitinase and is usually encoded by a single gene.

Open Access | Efficacy of PermaNet(R) 2.0 and PermaNet(R) 3.0 against insecticide-resistant Anopheles gambiae in experimental huts in Cote d'Ivoire

June 28, 2011 - 06:52 -- Kabogo Ndegwa
Koudou BG, Koffi AA, Malone D, Hemingway J
Malaria Journal 2011, 10:172 (23 June 2011)

This study showed that unwashed PermaNet(R) 3.0 caused significantly higher mortality against pyrethroid resistant An. gambiae s.s and Culex spp than PermaNet(R) 2.0 and the CTN.

Medical Treatment: 

Cytochrome P450 6M2 from the malaria vector Anopheles gambiae metabolizes pyrethroids: Sequential metabolism of deltamethrin revealed

June 21, 2011 - 13:55 -- Kabogo Ndegwa
Bradley J. Stevenson, Jaclyn Bibby, Mark J.I. Paine, et al.
Insect Biochemistry and Molecular Biology, Volume 41, Issue 7, July 2011, Pages 492-502

Resistance to pyrethroid insecticides in the malaria vector Anopheles gambiae is a major threat to malaria control programmes.

Open Access | Alternative splicing of the Anopheles gambiae Dscam gene in diverse Plasmodium falciparum infections

June 9, 2011 - 14:34 -- Kabogo Ndegwa
Smith PH, Mwangi JM, Afrane YA, Yan G, Obbard DJ, Ranford-Cartwright LC, Little TJ
Malaria Journal 2011, 10:156 (8 June 2011)

While the data clearly indicate that AgDscam diversity increases with P. falciparum exposure, they do not suggest that AgDscam diversity rises further in response to increased parasite diversity.

Open Access | Anopheles gambiae distribution and insecticide resistance in the cities of Douala and Yaounde (Cameroon): influence of urban agriculture and pollution

June 9, 2011 - 13:41 -- Kabogo Ndegwa
Antonio-Nkondjio C, Tene Fossog B, Ndo C, Menze Djantio B, Zebaze Togouet S, Awono-Ambene P, Costantini C, Wondji CS, Ranson H
Malaria Journal 2011, 10:154 (8 June 2011)

The data confirm high selection pressure on mosquitoes originating from urban areas and suggest urban agriculture rather than pollution as the major factor driving resistance to insecticide.


Open Access | A comprehensive gene expression atlas of sex- and tissue-specificity in the malaria vector, Anopheles gambiae.

June 8, 2011 - 14:26 -- Patrick Sampao
Dean A Baker, Tony Nolan, Bettina Fischer, Alex Pinder, Andrea Crisanti and Steven Russell
BMC Genomics 2011, 12:296, 7 June 2011

In this study, we present transcription profiles for ~82% of annotated Anopheles genes in dissected adult male and female tissues.


Open Access | Malaria prevalence pattern observed in the highland fringe of Butajira, Southern Ethiopia: a longitudinal study from parasitological and entomological survey

June 8, 2011 - 07:01 -- Kabogo Ndegwa
Tesfaye S, Belyhun Y, Teklu T, Mengesha T, Petros B
Malaria Journal 2011, 10:153 (7 June 2011)

Malaria parasite and its vectors were found to be common during transmission periods in the highland fringes of Butajira.


Open Access | The contribution of aestivating mosquitoes to the persistence of Anopheles gambiae in the Sahel

June 7, 2011 - 07:33 -- Kabogo Ndegwa
Adamou A, Dao A, Timbine S, Kassogue Y, Yaro AS, Diallo M, Traore SF, Huestis DL, Lehmann T
Malaria Journal 2011, 10:151 (6 June 2011)

These results support the hypothesis that the M form persist in the arid Sahel primarily by aestivation, whereas the S form and An. arabiensis rely on migration from distant locations. Implications for malaria control are discussed.


Open Access | Biochemical Comparison of Anopheles gambiae and Human NADPH P450 Reductases Reveals Different 2′-5′-ADP and FMN Binding Traits

June 6, 2011 - 07:41 -- Kabogo Ndegwa
Lu-Yun Lian, Philip Widdowson, Lesley A. McLaughlin, Mark J. I. Paine
PLoS ONE 6(5): e20574

NADPH-cytochrome P450 oxidoreductase (CPR) plays a central role in chemical detoxification and insecticide resistance in Anopheles gambiae, the major vector for malaria.


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