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toxicity

Selective toxicity of dihydroartemisinin on human CD34+ erythroid cell differentiation

September 14, 2010 - 13:03 -- Patrick Sampao
Author(s): 
Sara Finaurini, Luisa Ronzoni, Alessandra Colancecco, Alessandra Cattaneo, Maria Domenica Cappellini, Stephen A. Ward, Donatella Taramelli
Reference: 
Toxicology, Volume 276, Issue 2, 9 October 2010, Pages 128-134

This is the first demonstration that DHA affects human erythropoiesis in vitro, in a dose- and time-dependent manner; the target population seems to be the pro-erythroblast and basophilic erythroblast stage, suggesting that DHA toxicity is limited to primitive human erythropoiesis.

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Synthesis, antimalarial activity, and cellular toxicity of new arylpyrrolylaminoquinolines

September 6, 2010 - 09:29 -- Patrick Sampao
Author(s): 
Manolo Casagrande, Nicoletta Basilico, Chiara Rusconi, Donatella Taramelli, Anna Sparatore
Reference: 
Bioorganic & Medicinal Chemistry, Volume 18, Issue 18, 15 September 2010, Pages 6625-6633

The antimalarial activity of this new class of compounds seems to be related to the inhibition of heme detoxification process of parasites, as in the case of chloroquine.

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Antiplasmodial activity and toxicity of crude extracts from alternatives parts of plants widely used for the treatment of malaria in Burkina Faso: contribution for their preservation

January 10, 2010 - 15:06 -- Ingeborg van Schayk
Author(s): 
Adama Gansané, Souleymane Sanon, Lamoussa P. Ouattara, Abdoulaye Traoré, Sébastien Hutter, Evelyne Ollivier, Nadine Azas, Alfred S. Traore, Innocent P. Guissou, Sodiomon B. Sirima & Issa Nebié
Reference: 
Parasitology Research, Volume 106, Number 2 / January, 2010 : 335-340

In order to prevent the destruction of the ecology and to sustain the flora mainly for medicinal plants, we investigated on alternative parts taken from four plants already known to display antiplasmodial activities and largely used by traditional healers in sub-Saharan Africa.

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