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Open Access | Extreme CD8 T Cell Requirements for Anti-Malarial Liver-Stage Immunity following Immunization with Radiation Attenuated Sporozoites

August 2, 2010 - 13:26 -- Patrick Sampao
Nathan W. Schmidt, Noah S. Butler, Vladimir P. Badovinac, John T. Harty
PLoS Pathog 6(7): e1000998

Here, we used surrogate T cell activation markers to identify and track whole-parasite, RAS-vaccine-induced effector and memory CD8 T cell responses. Our data show that the differential susceptibility of RAS-immune inbred mouse strains to Plasmodium berghei or P. yoelii sporozoite challenge does not result from host- or parasite-specific decreases in the CD8 T cell response.

Medical Condition: 

Immunization with VAR2CSA-DBL5 Recombinant Protein Elicits Broadly Cross-Reactive Antibodies to Placental Plasmodium falciparum-Infected Erythrocytes

April 19, 2010 - 14:31 -- Patrick Sampao
Marion A., Megan M., et al
Infection and Immunity Vol. 78, No. 5, p. 2248-2256, May 2010

These findings demonstrate that the major PfEMP1 variant expressed by placental isolates exposes strain-transcendent epitopes that can be targeted by vaccination and may have application for pregnancy malaria vaccine development.

Medical Treatment: 

Open Access | Prime-Boost Immunization with Adenoviral and Modified Vaccinia Virus Ankara Vectors Enhances the Durability and Polyfunctionality of Protective Malaria CD8+ T-Cell Responses

January 10, 2010 - 14:29 -- Ingeborg van Schayk
Arturo Reyes-Sandoval, Tamara Berthoud, Nicola Alder, Loredana Siani, Sarah C. Gilbert, Alfredo Nicosia, Stefano Colloca, Riccardo Cortese, and Adrian V. S. Hill
Infect. Immun. 2010;78 145-153 Open Access

These data highlight the ability of optimized viral vector prime-boost regimens to generate more protective and sustained CD8+ T-cell responses, and our results encourage a more nuanced assessment of the importance of inducing polyfunctional CD8+ T cells by vaccination.

Medical Treatment: 
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