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T-cell response

Open Access | Prime-Boost Immunization with Adenoviral and Modified Vaccinia Virus Ankara Vectors Enhances the Durability and Polyfunctionality of Protective Malaria CD8+ T-Cell Responses

January 10, 2010 - 14:29 -- Ingeborg van Schayk
Arturo Reyes-Sandoval, Tamara Berthoud, Nicola Alder, Loredana Siani, Sarah C. Gilbert, Alfredo Nicosia, Stefano Colloca, Riccardo Cortese, and Adrian V. S. Hill
Infect. Immun. 2010;78 145-153 Open Access

These data highlight the ability of optimized viral vector prime-boost regimens to generate more protective and sustained CD8+ T-cell responses, and our results encourage a more nuanced assessment of the importance of inducing polyfunctional CD8+ T cells by vaccination.

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