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chloroquine resistance

Confirmation of Plasmodium falciparum in vitro resistance to monodesethylamodiaquine and chloroquine in Dakar, Senegal, in 2015

March 21, 2017 - 16:15 -- Open Access
Author(s): 
Silman Diawara, Marylin Madamet, Bruno Pradines, et al.
Reference: 
Malaria Journal 2017 16:118, 16 March 2017

The establishment of a reduced susceptibility to monodesethylamodiaquine as well as chloroquine resistance, and the emergence of a reduced susceptibility to doxycycline are disturbing.

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Vivax malaria and chloroquine resistance: a neglected disease as an emerging threat

April 14, 2015 - 17:25 -- Open Access
Author(s): 
Waheed AA, Ghanchi NK, Rehman KA, Raza A, Mahmood SF, Beg MA
Reference: 
Malaria Journal 2015, 14 :146 (8 April 2015)

In Pakistan, Plasmodium vivax contributes to major malaria burden.

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Investigation of the Plasmodium falciparum Food Vacuole through Inducible Expression of the Chloroquine Resistance Transporter (PfCRT)

June 20, 2012 - 09:15 -- Kabogo Ndegwa
Author(s): 
Florian Ehlgen, James S. Pham, Tania de Koning-Ward, Alan F. Cowman, Stuart A. Ralph
Reference: 
PLoS ONE 7(6): e38781

MalariaWorldHaemoglobin degradation during the erythrocytic life stages is the major function of the food vacuole (FV) of Plasmodium falciparum and the target of several anti-malarial drugs that interfere with this metabolic pathway, killing the parasite.

Genetic diversity in the merozoite surface protein 1 and 2 genes o Plasmodium falciparum from the Artibonite Valley of Haiti

November 17, 2011 - 10:53 -- Kabogo Ndegwa
Author(s): 
Berlin Londono-Renteria, Thomas P. Eisele, Joseph Keating, Adam Bennett, Donald J. Krogstad
Reference: 
Acta Tropica, Volume 121, Issue 1, January 2012, Pages 6-12

MalariaWorldDescribing genetic diversity of the Plasmodium falciparum parasite provides important information about the local epidemiology of malaria.

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A Partial Convergence in Action of Methylene Blue and Artemisinins: Antagonism with Chloroquine, a Reversal with Verapamil, and an Insight into the Antimalarial Activity of Chloroquine

October 6, 2011 - 09:39 -- Kabogo Ndegwa
Author(s): 
Richard K. Haynes, Kwan-Wing Cheu, Ka-Yan Li, Maggie Mei-Ki Tang, Ho-Ning Wong, Min-Jiao Chen, Zu-Feng Guo, Zhi-Hong Guo, Paolo Coghi, Diego Monti
Reference: 
ChemMedChem, Volume 6, Issue 9, pages 1603–1615, September 5, 2011

MalariaWorldArtemisinins rapidly oxidize leucomethylene blue (LMB) to methylene blue (MB); they also oxidize dihydroflavins such as the reduced conjugates RFH2 of riboflavin (RF), and FADH2 of the cofactor flavin adenine dinucleotide (FAD), to the corresponding flavins.

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Detecting mutations in PfCRT and PfMDR1 genes among Plasmodium falciparum isolates from Saudi Arabia by pyrosequencing

July 26, 2011 - 07:16 -- Kabogo Ndegwa
Author(s): 
Saad M. Bin Dajem, Adel Ali H. Al-Sheikh, Marie Fe Bohol, Mohammad Alhawi, Mohammed N. Al-Ahdal & Ahmed Al-Qahtani
Reference: 
Parasitology Research, Volume 109, Number 2, 291-296

The emergence of chloroquine resistance in Plasmodium falciparum is a significant public health problem where malaria is endemic.

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Open Access | On the Mechanism of Chloroquine Resistance in Plasmodium falciparum

November 26, 2010 - 13:59 -- Kabogo Ndegwa
Author(s): 
Mauro Chinappi, Allegra Via, Paolo Marcatili, Anna Tramontano
Reference: 
PLoS ONE 5(11): e14064

Resistance to chloroquine of malaria strains is known to be associated with a parasite protein named PfCRT, the mutated form of which is able to reduce chloroquine accumulation in the digestive vacuole of the pathogen.

Reinvestigation of structure–activity relationship of methoxylated chalcones as antimalarials: Synthesis and evaluation of 2,4,5-trimethoxy substituted patterns as lead candidates derived from abundantly available natural β-asarone

October 13, 2010 - 10:10 -- Kabogo Ndegwa
Author(s): 
Rakesh Kumar, Dinesh Mohanakrishnan, Abhishek Sharma, Naveen Kumar Kaushik, Kalpana Kalia, Arun Kumar Sinha, Dinkar Sahal
Reference: 
European Journal of Medicinal Chemistry, Volume 45, Issue 11, November 2010, Pages 5292-5301

We have examined the antimalarial structure–activity relationship of a series of methoxylated chalcones (A–CHdouble bond; length as m-dashCH–CO–B) against Plasmodium falciparum (3D7 strain) using fluorescence-based SYBR Green assay. Our study has revealed that electron releasing methoxy groups on ring A and electron withdrawing groups on ring B increases antimalarial potency while the positional interchange of these groups causes a decrease.

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pfmdr1 Amplification and Fixation of pfcrt Chloroquine Resistance Alleles in Plasmodium falciparum in Venezuela

March 25, 2010 - 20:25 -- Patrick Sampao
Author(s): 
Sean Griffing,Luke Syphard,Sankar Sridaran, Andrea M. McCollum,Tonya Mixson-Hayden, Sumiti Vinayak,Leopoldo Villegas,John W. Barnwell, Ananias A. Escalante, and Venkatachalam Udhayakumar
Reference: 
Antimicrobial Agents and Chemotherapy, April 2010, p. 1572-1579, Vol. 54, No. 4

In order to assess how historical drug policies impacted Plasmodium falciparum in Venezuela, we examined molecular changes in genes associated with drug resistance.

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Open Access | Potential contribution of prescription practices to the emergence and spread of chloroquine resistance in south-west Nigeria: caution in the use of artemisinin combination therapy

January 7, 2010 - 13:22 -- Ingeborg van Schayk
Author(s): 
Grace O Gbotosho, Christian T Happi, Abideen Ganiyu, Olumide A Ogundahunsi, Akin Sowunmi, Ayoade M Oduola
Reference: 
Malaria Journal 2009, 8:313 (30 December 2009)

The results from this study describe a lack of adherence to national treatment guidelines, especially in the private sector, and a relationship between prescription practices and dissemination of drug resistant falciparum malaria.

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