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protein export

The host targeting motif in exported Plasmodium proteins is cleaved in the parasite endoplasmic reticulum

March 26, 2010 - 16:40 -- Kabogo Ndegwa
Author(s): 
Andrew R. Osborne, Kaye D. Speicher, Pamela A. Tamez, Souvik Bhattacharjee, David W. Speicher, Kasturi Haldar
Reference: 
Molecular and Biochemical Parasitology, Volume 171, Issue 1, May 2010, Pages 25-31

Here, we generate parasite lines expressing HT motif containing proteins that are localized to different compartments within the parasite or host cell.

Protein export marks the early phase of gametocytogenesis of the human malaria parasite plasmodium falciparum

March 25, 2010 - 13:54 -- Ingeborg van Schayk
Author(s): 
Francesco Silvestrini, Edwin Lasonder, Anna Olivieri, Grazia Camarda, Ben van Schaijk, Massimo Sanchez, Sumera Younis Younis, Robert Sauerwein, and Pietro Alano
Reference: 
Mol. Cell. Proteomics. published 22 March 2010, 10.1074/mcp.M900479-MCP200

This work indicates that protein export profoundly marks early sexual differentiation in P. falciparum, probably contributing to host cell remodelling in this phase of the life cycle, and that gametocyte-enriched molecules are recruited to modulate this process in gametocytogenesis.

Opinion: Protein export in malaria parasites: do multiple export motifs add up to multiple export pathways?

December 29, 2009 - 14:13 -- Patrick Sampao
Author(s): 
Tobias Spielmann and Tim-Wolf Gilberger
Reference: 
Trends in Parasitology, Volume 26, Issue 1, January 2010, Pages 6-10

We review recent data on the sequences mediating export of PNEPs and compare this process to PEXEL export taking into account novel findings on the function of this motif.

Medical Condition: 
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