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Evidence for negative selection on the gene encoding rhoptry-associated protein 1 (RAP-1) in Plasmodium spp.

May 27, 2010 - 14:51 -- Patrick Sampao
Elizabeth M. R., Amanda C. P., et al.
Infection, Genetics and Evolution, Volume 10, Issue 5, July 2010, Pages 655-661

We investigated the genetic diversity of orthologous genes encoding the rhoptry-associated protein 1 (RAP-1), a low polymorphic protein of malarial parasites that is involved in erythrocyte invasion.

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Interaction between Plasmodium falciparum Apical Membrane Antigen 1 and the Rhoptry Neck Protein Complex Defines a Key Step in the Erythrocyte Invasion Process of Malaria Parasites

May 3, 2010 - 14:12 -- Patrick Sampao
Dave R., Christopher A., et al.
The Journal of Biological Chemistry, 285, 14815-14822.

Here we show that the R1 peptide binds the PfAMA1 hydrophobic trough and demonstrate that binding to this region prevents its interaction with the PfRON complex. We show that this defined association between PfAMA1 and the PfRON complex occurs after reorientation and engagement of the actomyosin motor and argue that it precedes rhoptry release.

Open Access | Plasmodium vivax: Induction of CD4+CD25+FoxP3+ Regulatory T Cells during Infection Are Directly Associated with Level of Circulating Parasites

March 17, 2010 - 13:51 -- Ingeborg van Schayk
Lilian Lacerda Bueno, Cristiane Guimarães Morais, Fernanda Fortes Araújo, Juliana Assis Silva Gomes, Rodrigo Corrêa-Oliveira, Irene Silva Soares, Marcus Vinícius Lacerda, Ricardo Toshio Fujiwara, Érika Martins Braga
PLoS ONE 5(3): e9623

Our findings indicate that malaria vivax infection lead to an increased number of activated Treg cells that are highly associated with parasite load, which probably exert an important contribution to the modulation of immune responses during P. vivax infection.

Subpatent infection with nucleoside transporter 1-deficient Plasmodium blood stage parasites confers sterile protection against lethal malaria in mice

March 15, 2010 - 13:55 -- Ingeborg van Schayk
Ahmed S. I. Aly, Megan J. Downie, Choukri Ben Mamoun and Stefan H. I. Kappe
Cellular Microbiology Early View

The study demonstrates that genetic manipulation provides a platform for the designed, complete attenuation of malaria parasite blood stages and suggests testing the safety and efficacy of P. falciparum NT1 knockout strains in humans.

Opinion: Protein export in malaria parasites: do multiple export motifs add up to multiple export pathways?

December 29, 2009 - 14:13 -- Patrick Sampao
Tobias Spielmann and Tim-Wolf Gilberger
Trends in Parasitology, Volume 26, Issue 1, January 2010, Pages 6-10

We review recent data on the sequences mediating export of PNEPs and compare this process to PEXEL export taking into account novel findings on the function of this motif.

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