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parasites

Open Access | Invited Speaker Presentation: Transporters used by parasites as drug targets: tempting but underexploited

November 3, 2010 - 13:37 -- Patrick Sampao
Author(s): 
Henry Staines
Reference: 
Malaria Journal 2010, 9(Suppl 2):I9 (20 October 2010)

Here are presented recent studies on this potential antimalarial target, utilising the rodent P. berghei model to investigate the physiological importance of D-glucose transport in transmission and liver life cycle stages and to generate an in vivo model for testing inhibitors of PfHT.

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Open Access | Invited Speaker Presentation: A common protein export pathway in malaria parasites

November 3, 2010 - 12:33 -- Patrick Sampao
Author(s): 
Brendan Crabb, Hayley Bullen, Sarah Charnaud, Silvia Haase, Justin Boddey, Alan Cowman, Tania de Koning-Ward, Paul Gilson
Reference: 
Malaria Journal 2010, 9(Suppl 2):I3 (20 October 2010)

Protozoan parasites that cause malaria export hundreds of proteins into their host red blood cell cytosol, and some even beyond that to the extracellular environment.

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Malaria Vaccine Design: Immunological Considerations

November 2, 2010 - 08:36 -- Kabogo Ndegwa
Author(s): 
Michael F. Good, Denise L. Doolan
Reference: 
Immunity, Volume 33, Issue 4, 29 October 2010, Pages 555-566

The concept of a malaria vaccine has sparked great interest for decades; however, the challenge is proving to be a difficult one.

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Open Access | Experimental evolution, genetic analysis and genome re-sequencing reveal the mutation conferring artemisinin resistance in an isogenic lineage of malaria parasites

September 17, 2010 - 13:45 -- Patrick Sampao
Author(s): 
Hunt P., Martinelli A., et al.
Reference: 
BMC Genomics 2010, 11:499 (16 September 2010)

Here, we combine in vivo experimental evolution, a rapid genetic strategy and whole genome re-sequencing to identify the precise genetic basis of artemisinin resistance in a lineage of the rodent malaria parasite, Plasmodium chabaudi.

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Open Access | Dispatch: Co-infections with Plasmodium knowlesi and Other Malaria Parasites, Myanmar

August 23, 2010 - 14:23 -- Patrick Sampao
Author(s): 
Ning Jiang,1 Qiaocheng Chang,1 Xiaodong Sun,1 Huijun Lu, Jigang Yin, Zaixing Zhang, Mats Wahlgren, and Qijun Chen
Reference: 
Emerging Infectious Diseases, Volume 16, Number 9–September 2010

To determine the frequency of co-infections with Plasmodium species in southern Myanmar, we investigated the prevalence of P. knowlesi.

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Open Access | Plasmodium falciparum FIKK Kinase Members Target Distinct Components of the Erythrocyte Membrane

July 29, 2010 - 11:46 -- Kabogo Ndegwa
Author(s): 
Marta C. Nunes, Mami Okada, Christine Scheidig-Benatar, Brian M. Cooke, Artur Scherf
Reference: 
PLoS ONE 5(7): e11747

Our results suggest that FIKK members phosphorylate different membrane skeleton proteins of the infected erythrocyte in a stage-specific manner, inducing alterations in the mechanical properties of the parasite-infected red blood cell.

Open Access | Plasmodium falciparum parasites causing cerebral malaria share variant surface antigens, but are they specific?

July 29, 2010 - 10:32 -- Kabogo Ndegwa
Author(s): 
Kheliouen N, Viwami F, Lalya F, Tuikue-Ndam N, Eboumbou Moukoko EC, Rogier C, Deloron P, Aubouy A
Reference: 
Malaria Journal 2010, 9:220 (27 July 2010)

In conclusion, this study suggests the existence of serologically distinct VSACM and VSAUM. CM isolates were shown to share common epitopes. Specific antibody response to VSAUM was predominant, suggesting a relative low diversity of VSAUM in the study area.

Open Access | Commentary: Genome-wide association studies in Plasmodium species

July 15, 2010 - 09:43 -- Patrick Sampao
Author(s): 
Bridget Penman, Caroline Buckee, Sunetra Gupta and Sean Nee
Reference: 
BMC Biology 2010, 8:90

A recent study in BMC Genetics has found that populations of the malaria parasite Plasmodium vivax should be amenable to GWAS searching for a genetic basis of parasite pathogenicity.

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Update: Genetically engineered parasites: the solution to designing an effective malaria vaccine?

June 29, 2010 - 08:07 -- Patrick Sampao
Author(s): 
Joseph R. Fitchett, Mary K. Cooke
Reference: 
Trends in Parasitology, Volume 26, Issue 7, July 2010, Pages 322-323

Genetic engineering provides an ingenious method of attenuating Plasmodium falciparum parasites for next generation vaccines.

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Open Access | Lack of allele-specific efficacy of a bivalent AMA1 malaria vaccine

June 22, 2010 - 10:36 -- Kabogo Ndegwa
Author(s): 
Ouattara A, Mu J, Takala-Harrison S, Saye R, Sagara I, Dicko A, Niangaly A, Duan J, Ellis RD, Miller LH, Su X, Plowe CV, Doumbo OK
Reference: 
Malaria Journal 2010, 9:175 (21 June 2010)

This Phase 2 trial of a bivalent AMA1 malaria vaccine found no evidence of vaccine selection or strain-specific efficacy, suggesting that the extreme genetic diversity of AMA1 did not account for failure of the vaccine to provide protection.

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