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parasites

Open Access | var gene transcription and PfEMP1 expression in the rosetting and cytoadhesive Plasmodium falciparum clone FCR3S1.2

January 27, 2011 - 06:27 -- Kabogo Ndegwa
Author(s): 
Albrecht L, Moll K, Blomqvist K, Normark J, Chen Q, Wahlgren M
Reference: 
Malaria Journal 2011, 10:17 (25 January 2011)

The major transcript in the rosetting model parasite FCR3S1.2 is FCR3S1.2var2 (IT4var60).

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Short Communication: Implication of intracellular glutathione and its related enzymes on resistance of malaria parasites to the antimalarial drug arteether

January 21, 2011 - 08:42 -- Patrick Sampao
Author(s): 
Ramesh Chandra, L.M. Tripathi, J.K. Saxena, S.K. Puri
Reference: 
Parasitology International, Volume 60, Issue 1, January 2011, Pages 97-100

In this study, we examined the relationship between the intracellular levels of glutathione (GSH) and antioxidant enzymes and resistance to the artemisinin-based drug arteether in experimentally selected arteether-resistant Plasmodium vinckei.

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Review: A genotype and phenotype database of genetically modified malaria-parasites

December 31, 2010 - 13:42 -- Patrick Sampao
Author(s): 
Chris J. Janse., Andrew P. Waters., Shahid M. Khan., et al
Reference: 
Trends in Parasitology, Volume 27, Issue 1, January 2011, Pages 31-39

The RMgm database, www.pberghei.eu, is a web-based, manually curated, repository containing information on genetically modified rodent-malaria parasites.

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Fungal and Parasitic Infections: Persistence of Plasmodium falciparum Parasites in Infected Pregnant Mozambican Women after Delivery

December 23, 2010 - 08:49 -- Patrick Sampao
Author(s): 
Elisa Serra-Casas., Clara Menéndez., Alfredo Mayor., et al.
Reference: 
Infect. Immun., Jan 2011; 79: 298 - 304.

These results suggest that parasites infecting pregnant women persist after delivery and increase the risk of malaria during the postpartum period.

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Review: Central carbon metabolism of Plasmodium parasites

December 20, 2010 - 10:41 -- Patrick Sampao
Author(s): 
Kellen L. Olszewski, Manuel Llinás
Reference: 
Molecular and Biochemical Parasitology, Volume 175, Issue 2, February 2011, Pages 95-103

We focus primarily on the blood stages of Plasmodium falciparum, the most lethal of the human malaria parasites, but also integrate results from simian, avian and rodent models of malaria that were a major focus of early investigations into plasmodial metabolism.

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Open Access | Interrupting Malaria Transmission: Quantifying the Impact of Interventions in Regions of Low to Moderate Transmission

December 16, 2010 - 06:32 -- Kabogo Ndegwa
Author(s): 
Michelle L. Gatton, Qin Cheng
Reference: 
PLoS ONE 5(12): e15149

Malaria has been eliminated from over 40 countries with an additional 39 currently planning for, or committed to, elimination.

Transgenic Plasmodium that expresses HIV-1 Gag elicits immunity and protects mice against vaccinia virus-gag and malarial parasites

November 23, 2010 - 09:54 -- Patrick Sampao
Author(s): 
Bo Jiang, Li Qin, Yanhua Du, Nanzheng Peng, Ling Chen, Zhiwei Chen, Xiaoping Chen
Reference: 
Vaccine, Volume 28, Issue 50, 23 November 2010, Pages 7915-7922

We demonstrated a novel vaccination strategy that uses a live transgenic protozoan parasite-based bivalent vaccine to immunize mice and confer significant levels of protection against VV-gag and malarial parasite challenges.

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Chemotherapy, Within-Host Ecology and the Fitness of Drug-Resistant Malaria Parasites.

November 11, 2010 - 07:36 -- Patrick Sampao
Author(s): 
Silvie Huijben,William A. Nelson, Andrew R. Wargo, Derek G. Sim, Damien R. Drew,Andrew F.
Reference: 
Evolution, Volume 64, Issue 10, pages 2952–2968, October 2010

Here, we test the hypothesis that the spread of resistance can be slowed by reducing drug treatment and hence restricting competitive release.

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Open Access | Oral Presentation: Complete abrogation of sporozoite-induced sterile immunity by blood stage parasites of homologous and heterologous malaria species

November 8, 2010 - 14:48 -- Patrick Sampao
Author(s): 
Megumi Inoue, Jianxia Tang, Osamu Kaneko, Katsuyuki Yui, Richard Culleton
Reference: 
Malaria Journal 2010, 9(Suppl 2):O19 (20 October 2010)

There are ongoing efforts to develop a vaccine based on this system. Attenuation of sporozoites may be achieved via irradiation, genetic modification, or through the use of drugs targeting the blood stage parasite.

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