The major transcript in the rosetting model parasite FCR3S1.2 is FCR3S1.2var2 (IT4var60).
In this study, we examined the relationship between the intracellular levels of glutathione (GSH) and antioxidant enzymes and resistance to the artemisinin-based drug arteether in experimentally selected arteether-resistant Plasmodium vinckei.
No abstract available.
The RMgm database, www.pberghei.eu, is a web-based, manually curated, repository containing information on genetically modified rodent-malaria parasites.
These results suggest that parasites infecting pregnant women persist after delivery and increase the risk of malaria during the postpartum period.
We focus primarily on the blood stages of Plasmodium falciparum, the most lethal of the human malaria parasites, but also integrate results from simian, avian and rodent models of malaria that were a major focus of early investigations into plasmodial metabolism.
Malaria has been eliminated from over 40 countries with an additional 39 currently planning for, or committed to, elimination.
We demonstrated a novel vaccination strategy that uses a live transgenic protozoan parasite-based bivalent vaccine to immunize mice and confer significant levels of protection against VV-gag and malarial parasite challenges.
Here, we test the hypothesis that the spread of resistance can be slowed by reducing drug treatment and hence restricting competitive release.
There are ongoing efforts to develop a vaccine based on this system. Attenuation of sporozoites may be achieved via irradiation, genetic modification, or through the use of drugs targeting the blood stage parasite.