Here, we describe the identification of inhibitors from the Malaria Medicine Venture Malaria Box against the interaction of PfAtg8 with its E2-conjugating enzyme, PfAtg3, by surface plasmon resonance.
Date: Monday August 6th – Thursday August 9h, 2012
Location: National Conservation Training Center, Shepherdstown, West Virginia, USA
Sponsored by the NSF Research Coordination Network for Haemosporida of Terrestrial Vertebrates1
The focus of this study is to develop a robust, unsupervised and sensitive malaria screening technique with low material cost and one that has an advantage over other techniques in that it minimizes human reliance and is, therefore, more consistent in applying diagnostic criteria.
To survive within erythrocytes, malaria parasites modify the permeability of the host membrane to increase nutrient uptake.
Our phylogenomic analyses strongly support the hypotheses that the Laverania have been founded by a single Plasmodium species switching from birds to African great apes or vice versa.
This is a practical laboratory overview of current detection methods for malaria parasites, suitable for use in developing countries.
We investigated the prevalence and transmission of avian malaria parasite and determined the bloodmeal hosts of mosquitoes collected in a zoological garden in Tokyo, Japan, by using the polymerase chain reaction.
An evolutionary approach has the power to explain why patterns of investment vary between strains and during infections, giving important insights into parasite biology.
This advance holds promise for identifying and validating new targets for intervention against malaria.
This study reports the development and application of the piggyBac transposition system for the rodent malaria parasite P. berghei and the evaluation of its potential as a tool in forward genetic studies. P. berghei is the most frequently used malaria parasite model in gene function analysis since phenotype screens throughout the complete Plasmodium life cycle are possible both in vitro and in vivo.