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spleen

Parasitaemia levels in Plasmodium chabaudi infected-mice modify IFN-γ and IL-10 expression after a homologous or heterologous challenge

March 17, 2010 - 10:28 -- Ingeborg van Schayk
Author(s): 
M. Aguilar-Medina, R. Ramos-Payan, E. Arambula-Meraz, L. Sanchez-Torres, L. Favila-Castillo
Reference: 
Parasite Immunology Volume 32 Issue 4, Pages 267 - 274

CB6F1 mice infected with the nonlethal Plasmodium chabaudi chabaudi AS suffer parasitaemia levels up to 40% (full parasitaemia, FP) and develop both homologous and heterologous (against the lethal Plasmodium yoelii 17XL) protective immunity.

Migrating monocytes recruited to the spleen play an important role in control of blood stage malaria

December 29, 2009 - 12:39 -- Patrick Sampao
Author(s): 
Anne-Marit Sponaas, Ana Paula Freitas do Rosario, Cecile Voisine, Beatris Mastelic, Joanne Thompson, Sandra Koernig, William Jarra, Laurent Renia, Marjorie Mauduit, Alexandre J. Potocnik, and Jean Langhorne
Reference: 
Blood, 24 December 2009, Vol. 114, No. 27, pp. 5522-5531.

During Plasmodium chabaudi infection in mice, a population of CD11bhighLy6C+ monocytes are generated in bone marrow, most of which depend on the chemokine receptor CCR2 for migration from bone marrow to the spleen.

Medical Condition: 
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