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antigen

Open Access | PvRON2, a new Plasmodium vivax rhoptry neck antigen

March 15, 2011 - 08:57 -- Kabogo Ndegwa
Author(s): 
Arevalo-Pinzon G, Curtidor H, Patino LC, Patarroyo MA
Reference: 
Malaria Journal 2011, 10:60 (14 March 2011)

The identification and partial characterization of the first P. vivax rhoptry neck protein are described in the present study.

A recombinant vaccine based on domain II of Plasmodium vivax Apical Membrane Antigen 1 induces high antibody titres in mice

August 16, 2010 - 14:24 -- Patrick Sampao
Author(s): 
Fernanda G., Daniel Y., et al
Reference: 
Vaccine, Volume 28, Issue 38, 31 August 2010, Pages 6183-6190

These results demonstrate that a recombinant protein containing PvAMA-1 DII is immunogenic when administered in different adjuvant formulations, and indicate that this region of the AMA-1 protein should continue to be evaluated as part of a subunit vaccine against vivax malaria.

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Open Access | Protein Kinase A Dependent Phosphorylation of Apical Membrane Antigen 1 Plays an Important Role in Erythrocyte Invasion by the Malaria Parasite

June 29, 2010 - 09:43 -- Kabogo Ndegwa
Author(s): 
Kerstin Leykauf, Moritz Treeck, Paul R. Gilson, Thomas Nebl, Thomas Braulke, Alan F. Cowman, Tim W. Gilberger, Brendan S. Crabb
Reference: 
PLoS Pathog 6(6): e1000941

Apicomplexan parasites are obligate intracellular parasites that infect a variety of hosts, causing significant diseases in livestock and humans. The invasive forms of the parasites invade their host cells by gliding motility, an active process driven by parasite adhesion proteins and molecular motors.

Open Access | Protein Kinase A Dependent Phosphorylation of Apical Membrane Antigen 1 Plays an Important Role in Erythrocyte Invasion by the Malaria Parasite

June 7, 2010 - 11:47 -- Kabogo Ndegwa
Author(s): 
Kerstin Leykauf, Moritz Treeck, Paul R. Gilson, Thomas Nebl, Thomas Braulke, Alan F. Cowman, Tim W. Gilberger, Brendan S. Crabb
Reference: 
PLoS Pathog 6(6): e1000941

Apicomplexan parasites are obligate intracellular parasites that infect a variety of hosts, causing significant diseases in livestock and humans. The invasive forms of the parasites invade their host cells by gliding motility, an active process driven by parasite adhesion proteins and molecular motors.

Open Access | Prolonged Antigen Presentation Is Required for Optimal CD8+ T Cell Responses against Malaria Liver Stage Parasites

May 10, 2010 - 08:52 -- Kabogo Ndegwa
Author(s): 
Ian A. Cockburn, Yun-Chi Chen, Michael G. Overstreet, Jason R. Lees, Nico van Rooijen, Donna L. Farber, Fidel Zavala
Reference: 
PLoS Pathog 6(5): e1000877

Immunization with irradiated sporozoites is currently the most effective vaccination strategy against liver stages of malaria parasites, yet the mechanisms underpinning the success of this approach are unknown. Here we show that the complete development of protective CD8+ T cell responses requires prolonged antigen presentation.

Immunity to infection: Blood-stage Plasmodium berghei infection leads to short-lived parasite-associated antigen presentation by dendritic cells

April 19, 2010 - 13:09 -- Kabogo Ndegwa
Author(s): 
RJ Lundie, LJ Young, GM Davey, JA Villadangos, FR Carbone, WR Heath, BS Crabb
Reference: 
European Journal of Immunology, Volume 9999 Issue 999A

Despite extensive evidence that Plasmodium species are capable of stimulating the immune system, the association of malaria with a higher incidence of other infectious diseases and reduced responses to vaccination against unrelated pathogens, suggests the existence of immune suppression.

Small variant surface antigens and Plasmodium evasion of immunity

April 7, 2010 - 13:29 -- Patrick Sampao
Tags: 
Author(s): 
Jemmely, Noelle Yvonne1; Niang, Makhtar; Preiser, Peter Rainer
Reference: 
Future Microbiology, Volume 5, Number 4, April 2010 , pp. 663-682(20)

 

In this article, we highlight our current understanding of these variant antigens and provide insights on the mechanisms developed by malaria parasites to effectively avoid the host immune response and establish chronic infection.

Open Access | Antibody-Dependent Transplacental Transfer of Malaria Blood-Stage Antigen Using a Human Ex Vivo Placental Perfusion Model

December 15, 2009 - 20:42 -- Ingeborg van Schayk
Tags: 
Author(s): 
May K, Grube M, Malhotra I, Long CA, Singh S, et al.
Reference: 
PLoS ONE 4(11): e7986

Here we studied Plasmodium falciparum merozoite surface protein 1 (MSP1) that is released upon erythrocyte invasion.

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What you see is not what you get: implications of the brevity of antibody responses to malaria antigens and transmission heterogeneity in longitudinal studies of malaria immunity

October 29, 2009 - 12:37 -- Ingeborg van Schayk
Author(s): 
Samson M Kinyanjui, Philip Bejon, Faith H Osier, Peter C Bull, Kevin Marsh
Reference: 
Malaria Journal 2009, 8:242 (28 October 2009)

Failure to distinguish between individuals who do not get a clinical episode during follow-up because they were unexposed and those who are genuinely immune undermines our ability to assign a protective role to immune responses against malaria. The brevity of antibodies responses makes it difficult to assign the true serological status of an individual at any given time, i.e. those positive at a survey may be negative by the time they encounter the next infection.

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Heritability of Antibody Isotype and Subclass Responses to Plasmodium falciparum Antigens

October 25, 2009 - 16:06 -- Bart G.J. Knols
Author(s): 
Tetteh KKA, Whittle HC, et al.
Reference: 
PLoS ONE 4(10): e7381. doi:10.1371/journal.pone.0007381

Genome-wide approaches are now warranted to map the major genetic determinants of variable antibody isotype and subclass responses to malaria, alongside evaluation of their impact on infection and disease. Although plasma levels of IgG4 to malaria antigens are generally low, the exceptionally high heritability of levels of this subclass in children deserves particular investigation.

 

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