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Malaria vaccine efficacy: overcoming the helminth hurdle

July 19, 2010 - 13:26 -- Kabogo Ndegwa
JV Cruz-Chan, M Rosado-Vallado, E Dumonteil
Expert Review of Vaccines, July 2010, Vol. 9, No. 7, Pages 707-711

Several studies have documented that helminth infections can interfere with the development of the immune response of vaccines against different diseases, although some results have been contradictory.

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Open Access | Low doses of killed parasite in CpG elicit vigorous CD4+ T cell responses against blood-stage malaria in mice

July 19, 2010 - 12:16 -- Kabogo Ndegwa
A Pinzon-Charry, V McPhun, V Kienzle, C Hirunpetcharat, C Engwerda, J McCarthy, MF Good
J Clin Invest, July 12, 2010

Development of a vaccine that targets blood-stage malaria parasites is imperative if we are to sustainably reduce the morbidity and mortality caused by this infection.

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