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Open Access | Protein Kinase A Dependent Phosphorylation of Apical Membrane Antigen 1 Plays an Important Role in Erythrocyte Invasion by the Malaria Parasite

June 7, 2010 - 11:47 -- Kabogo Ndegwa
Kerstin Leykauf, Moritz Treeck, Paul R. Gilson, Thomas Nebl, Thomas Braulke, Alan F. Cowman, Tim W. Gilberger, Brendan S. Crabb
PLoS Pathog 6(6): e1000941

Apicomplexan parasites are obligate intracellular parasites that infect a variety of hosts, causing significant diseases in livestock and humans. The invasive forms of the parasites invade their host cells by gliding motility, an active process driven by parasite adhesion proteins and molecular motors.

Antibodies to Chondroitin Sulfate A–Binding Infected Erythrocytes: Dynamics and Protection during Pregnancy in Women Receiving Intermittent Preventive Treatment

April 9, 2010 - 17:46 -- Ingeborg van Schayk
Elizabeth H. Aitken, Bernard Mbewe, Mari Luntamo, Ken Maleta, Teija Kulmala, Marc‐James Friso, Freya J. I. Fowkes, James G. Beeson, Per Ashorn, and Stephen J. Rogerson
The Journal of Infectious Diseases 2010;201:1316–1325

Levels of IgG antibody to pregnancy‐specific VSAs decrease during receipt of IPTp. Antibody levels in early pregnancy did not predict clinical outcome. IPTp and decreasing malaria prevalence pose challenges for the evaluation of novel interventions for malaria during pregnancy.

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Small variant surface antigens and Plasmodium evasion of immunity

April 7, 2010 - 13:29 -- Patrick Sampao
Jemmely, Noelle Yvonne1; Niang, Makhtar; Preiser, Peter Rainer
Future Microbiology, Volume 5, Number 4, April 2010 , pp. 663-682(20)


In this article, we highlight our current understanding of these variant antigens and provide insights on the mechanisms developed by malaria parasites to effectively avoid the host immune response and establish chronic infection.

Review: Erythrocyte binding ligands in malaria parasites: Intracellular trafficking and parasite virulence

March 31, 2010 - 09:27 -- Patrick Sampao
Richard Culleton, Osamu Kaneko
Acta Tropica, Volume 114, Issue 3, June 2010, Pages 131-137

In this review, we describe the current understanding of the role of EBL and other erythrocyte binding ligands in erythrocyte invasion, and discuss the mechanisms by which they may control multiplication rates and virulence in malaria parasites.

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PfPI3K, a phosphatidylinositol-3 kinase from Plasmodium falciparum, is exported to the host erythrocyte and is involved in hemoglobin trafficking

March 31, 2010 - 07:18 -- Kabogo Ndegwa
Ankush Vaid, Ravikant Ranjan, Wynand A. Smythe, Heinrich C. Hoppe, and Pushkar Sharma
Blood, 25 March 2010, Vol. 115, No. 12, pp. 2500-2507

Our present studies suggest that PfPI3K, a novel phosphatidylinositol-3-kinase (PI3K) in Plasmodium falciparum, is exported to the host erythrocyte by the parasite in an active form.

Open Access | Epigenetic control of the variable expression of a Plasmodium falciparum receptor protein for erythrocyte invasion

February 5, 2010 - 16:59 -- Ingeborg van Schayk
Lubin Jiang, María José López-Barragán, Hongying Jiang, Jianbing Mu, Deepak Gaur, Keji Zhao, Gary Felsenfeld, and Louis H. Miller
PNAS February 2, 2010 vol. 107 no. 5 2224-2229

Our data indicate that the failure of Dd2 to express the sialic acid-independent invasion receptor gene RH4 is associated with the epigenetic silencing mark H3K9 trimethylation present throughout the cycle.


Absence of Erythrocyte Sequestration and Lack of Multicopy Gene Family Expression in Plasmodium falciparum from a Splenectomized Malaria Patient

October 25, 2009 - 16:01 -- Bart G.J. Knols
Predehl S, von Kalckreuth V, et al.
PLoS ONE 4(10): e7459. doi:10.1371/journal.pone.0007459

This case strongly supports the hypothesis that parasite surface proteins such as PfEMP1, A-type RIFIN or STEVOR are involved in interactions of infected erythrocytes with endothelial receptors mediating sequestration of mature asexual and immature sexual stages of P. falciparum. In contrast, multicopy gene families coding for B-type RIFIN and PfMC-2TM proteins may not be involved in sequestration, as these genes were transcribed in infected but not sequestered erythrocytes.


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