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Open Access | Heritability of the Human Infectious Reservoir of Malaria Parasites

July 2, 2010 - 11:11 -- Kabogo Ndegwa
Yaye Ramatoulaye Lawaly, Anavaj Sakuntabhai, Rick Paul, et al
PLoS ONE 5(6): e11358

The existence of a significant human genetic contribution to gametocyte prevalence in asymptomatic infections suggests that candidate gene and genome wide association approaches may be usefully applied to explore the underlying human genetics.


Review: Malaria gametocytogenesis

May 21, 2010 - 07:00 -- Patrick Sampao
David A. Baker
Molecular and Biochemical Parasitology, Volume 172, Issue 2, August 2010, Pages 57-65

Recent transcriptome, proteome and reverse genetic studies have added valuable information to that obtained from traditional studies. However, we still have no answer to the fundamental question regarding sexual development: ‘what triggers gametocytogenesis’?

Medical Treatment: 

Open Access | Substantial Contribution of Submicroscopical Plasmodium falciparum Gametocyte Carriage to the Infectious Reservoir in an Area of Seasonal Transmission

December 24, 2009 - 13:05 -- Ingeborg van Schayk
Ouédraogo AL, Bousema T, Schneider P, de Vlas SJ, Ilboudo-Sanogo E, et al.
PLoS ONE 4(12): e8410

Submicroscopical gametocyte carriage is common in an area of seasonal transmission in Burkina Faso and contributes substantially to the human infectious reservoir.


Open Access | Effects of mefloquine and artesunate mefloquine on the emergence, clearance and sex ratio of Plasmodium falciparum gametocytes in malarious children

December 23, 2009 - 11:35 -- Ingeborg van Schayk
Akintunde Sowunmi, Oluchi O Nkogho, Titilope M Okuboyejo, Grace O Gbotosho, Christian T Happi, Elsie O Adewoye
Malaria Journal 2009, 8:297 (16 December 2009)

Addition of artesunate to mefloquine significantly modified the emergence, clearance, and densities of gametocytes and has short-lived, but significant, sex ratio modifying effects in children from this endemic area.

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