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Review: Shape-shifting gametocytes: how and why does P. falciparum go banana-shaped?

October 24, 2012 - 16:16 -- Open Access
Matthew W.A. Dixon, Megan K. Dearnley, Eric Hanssen, Tim Gilberger, Leann Tilley
Trends in Parasitology, Volume 28, Issue 11, November 2012, Pages 471-478

MalariaWorldWe describe the machinery that elongates falciparum gametocytes and discuss its relation with the machinery that elongates the invasive zoites. We address the question – why do falciparum malaria gametocytes go banana-shaped? 

Functional Analysis of the Exported Type IV HSP40 Protein PfGECO in Plasmodium falciparum Gametocytes

November 2, 2011 - 14:08 -- Patrick Sampao
Belinda J. Morahan, Carolyn Strobel, Uzma Hasan, Beata Czesny, Pierre-Yves Mantel, Matthias Marti, Saliha Eksi, and Kim C. Williamson
Eukaryot. Cell, Nov 2011; 10: 1492 - 1503.

MalariaWorldUsing microarray analysis, we identified several genes with encoded secretory or export sequences that were differentially expressed during early gametocytogenesis.

Short Communication: A high-throughput assay for the identification of drugs against late-stage Plasmodium falciparum gametocytes

October 20, 2011 - 09:39 -- Patrick Sampao
Christopher L. Peatey, Timothy P. Spicer, Peter S. Hodder, Katharine R. Trenholme, Donald L. Gardiner
Molecular and Biochemical Parasitology, Volume 180, Issue 2, December 2011, Pages 127-131

MalariaWorldHere we describe the development of a robust and simple assay that is amenable to a high throughput format for the discovery of new antigametocyte drugs.

Epidemiology and Infectivity of Plasmodium falciparum and Plasmodium vivax Gametocytes in Relation to Malaria Control and Elimination

April 12, 2011 - 14:15 -- Patrick Sampao
Teun Bousema and Chris Drakeley
Clin. Microbiol. Rev., Apr 2011; 24: 377 - 410.

We discuss how the application of molecular techniques has led to the identification of submicroscopic gametocyte carriage and to a reassessment of the human infectious reservoir.

Medical Treatment: 

Brief Report: Quantification of Plasmodium falciparum Gametocytes by Magnetic Fractionation

January 10, 2011 - 08:20 -- Patrick Sampao
Stephan Karl, Timothy M. E. Davis, AND Tim G. St. Pierre
Am J Trop Med Hyg, Jan 2011; 84: 158 - 160.

A method of gametocyte quantitation in human blood was developed based on magnetic fractionation using commercially available magnetic fractionation columns (MFCs) and exploiting the magnetic susceptibility of mature Plasmodium falciparum gametocytes.

Development of a reverse transcription-loop-mediated isothermal amplification (RT-LAMP) for clinical detection of Plasmodium falciparum gametocytes

August 9, 2010 - 14:08 -- Patrick Sampao
Sureemas B., Sirasate B., et al.
Parasitology International, Volume 59, Issue 3, September 2010, Pages 414-420

In this study, reverse transcription-loop-mediated isothermal amplification (RT-LAMP) was developed for clinical detection of P. falciparum gametocytes.

Medical Treatment: 

Open Access | An improved method for the in vitro differentiation of Plasmodium falciparum gametocytes into ookinetes

July 13, 2010 - 13:22 -- Kabogo Ndegwa
Ghosh AK, Dinglasan RR, Ikadai H, Jacobs-Lorena M
Malaria Journal 2010, 9:194 (8 July 2010)

This simple and practical improvement over the prevailing methodology will facilitate the investigation of how this important human malaria parasite initiates its development in the mosquito and will contribute to the understanding of its transmission biology.

Open Access | Identification of a major rif transcript common to gametocytes and sporozoites of Plasmodium falciparum

May 31, 2010 - 12:03 -- Kabogo Ndegwa
Wang CW, Mwakalinga SB, Sutherland CJ, Schwank S, Sharp S, Hermsen CC, Sauerwein RW, Theander TG, Lavstsen T
Malaria Journal 2010, 9:147 (28 May 2010)

The most prominent variant surface antigen transcribed in both gametocytes and sporozoites of 3D7/NF54 is a single variant of the RIFIN protein family. This discovery may lead to the identification of the parasites binding ligands responsible for the adhesion during sexual stages and potentially to novel vaccine candidates.

Medical Treatment: 

Open Access | Revisiting the circulation time of Plasmodium falciparum gametocytes: molecular detection methods to estimate the duration of gametocyte carriage and the effect of gametocytocidal drugs

May 25, 2010 - 12:19 -- Kabogo Ndegwa
Bousema T, Okell L, Shekalaghe S, Griffin JT, Omar S, Sawa P, Sutherland C, Sauerwein R, Ghani AC, Drakeley C
Malaria Journal 2010, 9:136 (24 May 2010)

These findings confirm previous estimates of the circulation time of gametocytes, but indicate a much longer duration of (low density) gametocyte carriage after apparently successful clearance of asexual parasites.

Medical Condition: 

Open Access | Parameterization of high magnetic field gradient fractionation columns for applications with Plasmodium falciparum infected human erythrocytes

May 5, 2010 - 13:02 -- Patrick Sampao
Karl S, Davis TM, St. Pierre TG
Malaria Journal 2010, 9:116 (3 May 2010)

A detailed quantitative analysis of a batchwise magnetic fractionation process for malaria infected erythrocytes using high gradient magnetic fractionation columns was performed. The models applied in this study allow the prediction of capture efficiency if the initial infected cell concentration and the flow rate are known.



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