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resistance

High chloroquine treatment failure rates and predominance of mutant genotypes associated with chloroquine and antifolate resistance among falciparum malaria patients from the island of Car Nicobar, India

April 16, 2010 - 12:50 -- Patrick Sampao
Author(s): 
Manoj K. Das, Vanshika Lumb, Pooja Mittra, Shiv S. Singh, Aditya P. Dash and Yagya D. Sharma
Reference: 
Journal of Antimicrobial Chemotherapy

A WHO protocol with a 28 day follow-up schedule was used for chloroquine efficacy studies. Finger-prick blood from P. falciparum malaria patients was used for sequencing the genes encoding PfCRT (exon 2), dihydrofolate reductase (PfDHFR) and dihydropteroate synthetase (PfDHPS).

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Origins and spread of pfdhfr mutant alleles in Plasmodium falciparum

March 31, 2010 - 11:08 -- Patrick Sampao
Author(s): 
Toshihiro Mita
Reference: 
Acta Tropica, Volume 114, Issue 3, June 2010, Pages 166-170

Here, I review recent studies about the history of SP usage and the evolution and spread of resistant lineages while addressing the technical issue of microsatellite analysis.

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Mechanisms of Resistance: Evidence of Selective Sweeps in Genes Conferring Resistance to Chloroquine and Pyrimethamine in Plasmodium falciparum Isolates in India

February 25, 2010 - 21:28 -- Kabogo Ndegwa
Author(s): 
Tonya Mixson-Hayden, Vidhan Jain, Neeru Singh et al.
Reference: 
Antimicrobial Agents and Chemotherapy, March 2010, Pages 997-1006, Volume 54, No. 3

We tested whether chloroquine- and antifolate drug-resistant genotypes would be more commonly associated with cases of cerebral malaria than with cases of mild malaria in the province of Jabalpur, India, by genotyping the dhps, dhfr, pfmdr-1, and pfcrt genes using pyrosequencing, direct sequencing, and real-time PCR.

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Monitoring of in vitro susceptibilities and molecular markers of resistance of Plasmodium falciparum isolates from Thai-Myanmar border to chloroquine, quinine, mefloquine and artesunate

January 21, 2010 - 09:13 -- Kabogo Ndegwa
Author(s): 
Wanna Chaijaroenkula, Raewadee Wisedpanichkija and Kesara Na-Bangchang
Reference: 
Acta Tropica, Volume 113, Issue 2, February 2010, Pages 190-194

The objective of this work was to broaden the insight into the molecular mechanisms of resistance of P. falciparum to quinoline-containing antimalarials and artemisinin derivatives.

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Open Access | Costs of insensitive acetylcholinesterase insecticide resistance for the malaria vector Anopheles gambiae homozygous for the G119S mutation

January 13, 2010 - 13:31 -- Ingeborg van Schayk
Author(s): 
Luc Djogbenou, Valerie Noel, Philip Agnew
Reference: 
Malaria Journal 2010, 9:12 (13 January 2010)

The paper provides valuable information on fitness costs to the homozygote susceptible and resistant strains. The authors show that the largest impact is on pupal mortality, while the costs of earlier pupation and smaller adult size are less clear.

Open Access | Molecular markers of resistance to sulphadoxine-pyrimethamine one year after implementation of intermittent preventive treatment of malaria in infants in Mali

January 13, 2010 - 13:20 -- Ingeborg van Schayk
Author(s): 
Alassane Dicko, Issaka Sagara, Abdoulaye A Djimde, Sidy O Toure, Mariam Traore, Souleymane Dama, Abdoulbaki I Diallo, Amadou Barry, Mohamed Dicko, Oumar M Coulibaly, Christophe Rogier, Alexandra de Sousa, Ogobara K Doumbo
Reference: 
Malaria Journal 2010, 9:9 (10 January 2010)

A paper that addresses the issue of possible selection of drug resistant parasites in the context of Intermittent Preventive Treatment in infants. Importantly, this study evaluates the impact of the intervention at community level, in a context of a large scale implementation.

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Open Access | Plasmodium falciparum resistance to anti-malarial drugs in Papua New Guinea: evaluation of a community-based approach for the molecular monitoring of resistance

January 13, 2010 - 13:15 -- Ingeborg van Schayk
Author(s): 
Jutta Marfurt, Thomas A Smith, Ian M Hastings, Ivo Muller, Albert Sie, Olive Oa, Moses Baisor, John C Reeder, Hans-Peter Beck, Blaise Genton
Reference: 
Malaria Journal 2010, 9:8 (7 January 2010)

Interesting paper aiming at investigating the role and applicability of the molecular drug resistance profiles in community samples in Papua New Guinea.

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Open Access| Residual Antimalarials in Malaria Patients from Tanzania – Implications on Drug Efficacy Assessment and Spread of Parasite Resistance

December 22, 2009 - 12:06 -- Ingeborg van Schayk
Author(s): 
Hodel EM, Kabanywanyi AM, Malila A, Zanolari B, Mercier T, et al.
Reference: 
PLoS ONE 4(12): e8184

We report the findings from baseline plasma sampling of malaria patients prior to inclusion into an in vivo study in Tanzania and discuss the implications of residual concentrations of antimalarials in this setting.

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Open Access | Clinical Microbiology : Therapeutic efficacy of chloroquine and sequence variation in pfcrt gene among patients with falciparum malaria in central India

December 17, 2009 - 13:17 -- Kabogo Ndegwa
Author(s): 
Praveen Kumar Bharti, Mohammad Tauqeer Alam, Robert Boxer, Man Mohan Shukla, Sant P. Gautam, Yagya D. Sharma, Neeru Singh
Reference: 
Tropical Medicine & International Health,Volume 15, Issue 1, Date: January 2010, Pages: 33-40

To assess the therapeutic efficacy of chloroquine (CQ) treatment against uncomplicated Plasmodium falciparum infections in a tribal population of central India (Madhya Pradesh) and to investigate the prevalence of mutant P. falciparum chloroquine-resistant transporter (pfcrt) gene in the parasite population.

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