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resistance

Open Access | Monitoring for Plasmodium falciparum drug resistance to artemisinin and artesunate in Binh Phuoc Province, Vietnam: 1998-2009

June 25, 2010 - 09:58 -- Kabogo Ndegwa
Author(s): 
Thanh NV, Toan TQ, Cowman AF, Casey GJ, Phuc BQ, Tien NT, Hung NM, Biggs B
Reference: 
Malaria Journal 2010, 9:181 (24 June 2010)

This study showed stable levels of P. falciparum sensitivity to artemisinin compounds in the two sites over a ten-year period.

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Review: The ABCs of multidrug resistance in malaria

June 22, 2010 - 08:43 -- Kabogo Ndegwa
Author(s): 
Jan B. Koenderink, Reginald A. Kavishe, Sanna R. Rijpma and Frans G.M. Russel
Reference: 
Trends in Parasitology, 11 June 2010

Expanding drug resistance could become a major problem in malaria treatment, as only a limited number of effective antimalarials are available.

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Open Access | Pyrethroid resistance in Anopheles gambiae leads to increased susceptibility to the entomopathogenic fungi Metarhizium anisopliae and Beauveria bassiana

June 18, 2010 - 12:11 -- Patrick Sampao
Author(s): 
Howard AF, Koenraadt CJ, Farenhorst M, Knols BG, Takken W
Reference: 
Malaria Journal 2010, 9:168 (16 June 2010)

The insecticide-resistant mosquito strain was susceptible to both species of fungus indicating that entomopathogenic fungi can be used in resistance management and integrated vector management programmes to target insecticide-resistant mosquitoes.

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Entomological survey and report of a knockdown resistance mutation in the malaria vector Anopheles gambiae from the Republic of Guinea

June 7, 2010 - 10:13 -- Patrick Sampao
Author(s): 
P. Carnevale, J.C. Toto, P. Guibert, M. Keita, S. Manguin
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 104, Issue 7, July 2010, Pages 484-489

The purpose of our entomological survey was to estimate mosquito biodiversity, infectivity rates and insecticide resistance levels in Anopheles species in four study sites in a mining area with high malaria transmission in southeastern Guinea.

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Evolutionary insights into insecticide resistance gene families of Anopheles gambiae

May 27, 2010 - 11:42 -- Patrick Sampao
Author(s): 
Hemlata Srivastava, Meenu Sharma, Jyotsana Dixit, Aparup Das
Reference: 
Infection, Genetics and Evolution, Volume 10, Issue 5, July 2010, Pages 620-628

We herein utilized the whole genome sequence information of the malaria vector Anopheles gambiae and inferred evolutionary pattern of the three known IR gene families (CYP, GST and COE).

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Open Access | Plasmodium chabaudi chabaudi malaria parasites can develop stable resistance to atovaquone with a mutation in the cytochrome b gene

May 24, 2010 - 13:18 -- Kabogo Ndegwa
Author(s): 
Afonso A, Neto Z, Castro H, Lopes D, Alves AC, Tomas AM, Rosario VD
Reference: 
Malaria Journal 2010, 9:135 (21 May 2010)

A mutation was found on the P. chabaudi cytb gene from the AS-ATQ sample a substitution at the residue Tyr268 for an Asn, this mutation is homologous to the one found in P. falciparum isolates resistant to ATQ.

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High prevalence of sulfadoxine/pyrimethamine resistance alleles in Plasmodium falciparum parasites from Bangladesh

May 5, 2010 - 08:10 -- Patrick Sampao
Author(s): 
Aung Swi Prue Marma, Toshihiro Mita, Hideaki Eto, Takahiro Tsukahara, Sumon Sarker, Hiroyoshi Endo
Reference: 
Parasitology International, Volume 59, Issue 2, June 2010, Pages 178-182

To assess the distribution of pfcrt, pfmdr1, dhfr, and dhps genotypes in Plasmodium falciparum, we conducted hospital- and community-based surveys in Bandarban, Bangladesh (near the border with Myanmar) in 2007 and 2008.

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Update: Monitoring antimalarial resistance: launching a cooperative effort

April 28, 2010 - 15:43 -- Patrick Sampao
Author(s): 
Carol Hopkins Sibley, Philippe J. Guerin, Pascal Ringwald
Reference: 
Trends in Parasitology, Volume 26, Issue 5, May 2010, Pages 221-224

A collaborative effort between the Global Malaria Program of the World Health Organization (WHO) and the WorldWide Antimalarial Resistance Network (WWARN) has recently been launched.

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Open Access | Alpha-tocopherol transfer protein disruption confers resistance to malarial infection in mice

April 20, 2010 - 09:25 -- Kabogo Ndegwa
Author(s): 
Herbas MS, Ueta YY, Ichikawa C, Chiba M, Ishibashi K, Shichiri M, Fukumoto S, Yokoyama N, Takeya M, Xuan X, Arai H, Suzuki H
Reference: 
Malaria Journal 2010, 9:101 (19 April 2010)

Various factors impact the severity of malaria, including the nutritional status of the host. Vitamin E, an intra and extracellular anti-oxidant, is one such nutrient whose absence was shown previously to negatively affect Plasmodium development.

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Mechanisms of Resistance: Selection of Known Plasmodium falciparum Resistance-Mediating Polymorphisms by Artemether-Lumefantrine and Amodiaquine- Sulfadoxine-Pyrimethamine but Not Dihydroartemisinin- Piperaquine in Burkina Faso

April 20, 2010 - 09:01 -- Kabogo Ndegwa
Author(s): 
Anyirékun Fabrice Somé, Yves Y. Séré, Christian Dokomajilar, Issaka Zongo, Noël Rouamba, Bryan Greenhouse, Jean-Bosco Ouédraogo, and Philip J. Rosenthal
Reference: 
Antimicrobial Agents and Chemotherapy, May 2010, p. 1949-1954, Vol. 54, No. 5

Artemether-lumefantrine (AL), dihydroartemisinin-piperaquine (DP), and amodiaquine-sulfadoxine-pyrimethamine (AQ-SP) offer excellent antimalarial efficacy but may select for parasite polymorphisms that decrease drug sensitivity. We evaluated the selection of known polymorphisms in genes encoding putative transporters (pfcrt and pfmdr1) and SP targets (pfdhfr and pfdhps) in parasites that caused new infections within 42 days of therapy for uncomplicated falciparum malaria in Burkina Faso.

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