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resistance

Open Access | Invited Speaker Presentation: Epidemiology of malaria resistance to Artemisinin: resistance or temporary tolerance

November 3, 2010 - 12:53 -- Patrick Sampao
Author(s): 
Carol Hopkins Sibley
Reference: 
Malaria Journal 2010, 9(Suppl 2):I5 (20 October 2010)

Artemisinin-based combination therapies (ACTs) are the recommended first-line treatment for Plasmodium falciparum malaria.

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Case Reports: pfmdr1 Amplification Associated with Clinical Resistance to Mefloquine in West Africa: Implications for Efficacy of Artemisinin Combination Therapies

October 1, 2010 - 09:36 -- Patrick Sampao
Author(s): 
Benoit W., Xavier I., et al.
Reference: 
J. Clin. Microbiol., Oct 2010; 48: 3797 - 3799.

We describe here a clinical failure in the treatment with mefloquine of acute falciparum malaria contracted in Africa and associated with in vitro mefloquine resistance and pfmdr1 copy number amplification.

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A geography of resistance mutations in Africa

September 8, 2010 - 11:02 -- Cally Roper

We have collated and mapped reports of the dhps K540E mutation in Africa. The mutation is a marker of resistance to SP (Fansidar) and has a remarkable geographical distribution.

Check the interactive map http://www.drugresistancemaps.org/maps/dhps540/ to see the distribution and check that your study has been included.

Inbarani Naidoo and Cally Roper

A Comparison of Methods to Detect and Quantify the Markers of Antimalarial Drug Resistance

September 2, 2010 - 15:04 -- Patrick Sampao
Author(s): 
Ian M. Hastings, Christian Nsanzabana, and Tom A. Smith
Reference: 
Am. J. Trop. Med. Hyg., 83(3), 2010, pp. 489-495

Simple counting dramatically reduced sample size and estimate precision, and we show that analysis of unambiguous samples is biased, leaving maximum likelihood or similar statistical inference as the only practical option.

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Review: The ABCs of multidrug resistance in malaria

August 23, 2010 - 13:31 -- Patrick Sampao
Author(s): 
Jan B. Koenderink, Reginald A. Kavishe, Sanna R. Rijpma, Frans G.M. Russel
Reference: 
Trends in Parasitology, Volume 26, Issue 9, September 2010, Pages 440-446

Here, we give an overview of the PlasmodiumABC family members with reference to their possible role in multidrug resistance.

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Review: Following the path of most resistance: dhps K540E dispersal in African Plasmodium falciparum

August 23, 2010 - 11:56 -- Patrick Sampao
Author(s): 
Inbarani Naidoo, Cally Roper
Reference: 
Trends in Parasitology, Volume 26, Issue 9, September 2010, Pages 447-456

We discuss whether there are common principles governing resistance dispersal in Africa and how these might guide surveillance in future.

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Open Access | Review: Major effect genes or loose confederations? The development of insecticide resistance in the malaria vector Anopheles gambiae

August 19, 2010 - 14:53 -- Patrick Sampao
Author(s): 
Brooke BD, Koekemoer LL
Reference: 
Parasites & Vectors 2010, 3:74 (17 August 2010)

Insecticide resistance is a common occurrence and has been intensively studied in the major malaria vector Anopheles gambiae, providing a useful model for examining how insecticide resistance develops and what pleiotropic effects are likely to emerge as a consequence of resistance.

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Open Access | Malaria parasite genome scan: insights into antimalarial resistance

July 12, 2010 - 14:29 -- Kabogo Ndegwa
Author(s): 
Bhavna Gupta, Gauri Awasthi and Aparup Das
Reference: 
Parasitology Research, Volume 107, Number 2 / July, 2010

Genome scan and genotype-phenotype association study offer excellent opportunities to unearth drug/vaccine targets in human pathogens including malaria parasites.

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