The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 10148 malaria professionals are enjoying the free benefits of MalariaWorld today

resistance

Perspective: Exploiting Malaria Drug Resistance to Our Advantage

August 8, 2011 - 11:46 -- Patrick Sampao
Author(s): 
Nick Cammack
Reference: 
Science Vol. 333 no. 6043 pp. 705-706, 5 August 2011

On page 724 of this issue, Yuan et al. (2) confront the issue head-on. Using high-throughput chemical and gene analysis methods, they not only identify potential new antimalarial drugs that could be used in combination to suppress the development of drug resistance but also characterize a common set of genetic loci and genes affected by these molecules.

Medical Condition: 

Slowing the evolution of insecticide resistance in mosquitoes: a mathematical model

July 6, 2011 - 13:39 -- Patrick Sampao
Author(s): 
Stephen A. Gourley, Rongsong Liu, Jianhong Wu
Reference: 
Proc. R. Soc. A 8 August 2011 vol. 467 no. 2132 2127-2148

We derive, analyse and compare two mathematical models, one for an insecticide that kills on exposure, and the other for an insecticide that targets only older mosquitoes.

Cytochrome P450 6M2 from the malaria vector Anopheles gambiae metabolizes pyrethroids: Sequential metabolism of deltamethrin revealed

June 21, 2011 - 13:55 -- Kabogo Ndegwa
Author(s): 
Bradley J. Stevenson, Jaclyn Bibby, Mark J.I. Paine, et al.
Reference: 
Insect Biochemistry and Molecular Biology, Volume 41, Issue 7, July 2011, Pages 492-502

Resistance to pyrethroid insecticides in the malaria vector Anopheles gambiae is a major threat to malaria control programmes.

The Membrane Attack Complex of Complement Is Required for the Development of Murine Experimental Cerebral Malaria

June 7, 2011 - 07:17 -- Kabogo Ndegwa
Author(s): 
Theresa N. Ramos, Meghan M. Darley, Xianzhen Hu, Oliver Billker, Julian C. Rayner, Malika Ahras, Jillian E. Wohler, and Scott R. Barnum
Reference: 
The Journal of Immunology June 15, 2011 vol. 186 no. 12 6657-6660

Cerebral malaria is the most severe complication of Plasmodium falciparum infection and accounts for a large number of malaria fatalities worldwide.

Open Access | Patterns of chloroquine use and resistance in sub-Saharan Africa: a systematic review of household survey and molecular data

May 11, 2011 - 12:06 -- Patrick Sampao
Author(s): 
Anne EP Frosch, Meera Venkatesan, Miriam K Laufer
Reference: 
Malaria Journal 2011, 10:116 (9 May 2011)

This study demonstrates that in 2006-2007 chloroquine and SP continued to be used at high rates in many African countries.

Continent: 
Medical Condition: 
Medical Treatment: 

Review: Update on genetic markers of quinine resistance in Plasmodium falciparum

April 11, 2011 - 14:56 -- Patrick Sampao
Author(s): 
John Okombo, Eric Ohuma, Stephane Picot, Alexis Nzila
Reference: 
Molecular and Biochemical Parasitology, Volume 177, Issue 2, June 2011, Pages 77-82

In this report, we have reviewed work on the in vivo efficacy and in vitro activity of quinine, and discussed recent data on genetic markers of resistance to this drug.

Medical Treatment: 

Short Communication: Malaria drug resistance is associated with defective DNA mismatch repair

April 11, 2011 - 14:04 -- Patrick Sampao
Author(s): 
Meryl A. Castellini, Jeffrey S. Buguliskis, Louis J. Casta, Charles E. Butz, Alan B. Clark, Thomas A. Kunkel, Theodore F. Taraschi
Reference: 
Molecular and Biochemical Parasitology, Volume 177, Issue 2, June 2011, Pages 143-147

These data imply that antimalarial drug resistance can result from defective MMR.

Medical Condition: 
Medical Treatment: 

Manual: Second edition “Prevention and Management of Insecticide Resistance in Vectors of Public Health Importance”

March 31, 2011 - 18:53 -- Ingeborg van Schayk
Author(s): 
Insecticide Resistance Action Committee (IRAC)
Reference: 
Insecticide Resistance Action Committee

IRAC has just published the second edition of the very popular manual “Prevention and Management of Insecticide Resistance in Vectors of Public Health Importance”.

Technology: 
Product: 

Opinion: How artemisinin-containing combination therapies slow the spread of antimalarial drug resistance

February 2, 2011 - 13:23 -- Patrick Sampao
Author(s): 
Ian Hastings
Reference: 
Trends in Parasitology, Volume 27, Issue 2, February 2011, Pages 67-72

Recent reports suggest that early stages of resistance to artemisinins and/or its partner drugs could be occurring, thus it is timely to briefly review exactly how ACTs slow the origin and spread of resistance and to interpret the threat of resistance within this context.

Medical Condition: 

Open Access | Spatial and temporal variation in the kdr allele L1014S in Anopheles gambiae s.s. and phenotypic variability in susceptibility to insecticides in Western Kenya

January 19, 2011 - 06:46 -- Kabogo Ndegwa
Author(s): 
Mathias DK, Ochomo EO, Atieli F, Ombok M, Bayoh M, Olang G, Muhia D, Kamau L, Vulule JM, Hamel MJ, Hawley WA, Walker ED, Gimnig JE
Reference: 
Malaria Journal 2011, 10:10 (14 January 2011)

The kdr L1014S allele has approached fixation in A. gambiae s.s. populations of western Kenya, and these same populations exhibit varying degrees of phenotypic resistance to DDT and pyrethroid insecticides.

Country: 

Pages

Subscribe to RSS - resistance