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Short Technical Report: Hemozoin-free Plasmodium falciparum mitochondria for physiological and drug susceptibility studies

October 6, 2010 - 13:25 -- Patrick Sampao
Michael W. Mather, Joanne M. Morrisey, Akhil B. Vaidya
Molecular and Biochemical Parasitology, Volume 174, Issue 2, December 2010, Pages 150-153

We describe here an improved procedure for the isolation of a mitochondrially enriched preparation from the trophozoite stage of erythrocytic Plasmodium falciparum, combining disruption by N2 cavitation and differential centrifugation with magnetic removal of hemozoin-associated material.

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Open Access | Artemisinin Directly Targets Malarial Mitochondria through Its Specific Mitochondrial Activation

March 17, 2010 - 11:02 -- Ingeborg van Schayk
Juan Wang, Liying Huang, Jian Li, Qiangwang Fan, Yicheng Long, Ying Li, Bing Zhou
PLoS ONE 5(3): e9582

We suggest that fundamental differences among mitochondria from different species delineate the action specificity of this class of drugs, and differing from many other drugs, the action specificity of artemisinins originates from their activation mechanism.

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