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Biochemical and biophysical characterisation of DBL1α1-varO, the rosetting domain of PfEMP1 from the VarO line of Plasmodium falciparum

February 11, 2010 - 09:04 -- Kabogo Ndegwa
Alexandre Juillerata, Sébastien Igoneta, Inès Vigan-Womas, Micheline Guillotte, Stéphane Gangnard, Grazyna Faure, Bruno Baron, Bertrand Raynal, Odile Mercereau-Puijalon and Graham A. Bentley
Molecular and Biochemical Parasitology, Volume 170, Issue 2, April 2010, Pages 84-92

Rosetting of erythrocytes infected with Plasmodium falciparum is frequently observed in children with severe malaria. This adhesion phenomenon has been linked to the DBL1α domain of P. falciparum erythrocyte membrane protein 1 (PfEMP1) in three laboratory clones: FCR3S1.2, IT4R29 and Palo Alto varO.

High Levels of Plasmodium falciparum Rosetting in All Clinical Forms of Severe Malaria in African Children

December 18, 2009 - 16:23 -- Ingeborg van Schayk
Ogobara K. Doumbo, Mahamadou A. Thera, Abdoulaye K. Koné, Ahmed Raza, Louisa J. Tempest, Kirsten E. Lyke, Christopher V. Plowe, AND J. Alexandra Rowe
Am J Trop Med Hyg 2009;81 987-993

We investigated the relationship between rosetting and clinical malaria in 209 Malian children enrolled in a case-control study of severe malaria.

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