Rosetting of erythrocytes infected with Plasmodium falciparum is frequently observed in children with severe malaria. This adhesion phenomenon has been linked to the DBL1α domain of P. falciparum erythrocyte membrane protein 1 (PfEMP1) in three laboratory clones: FCR3S1.2, IT4R29 and Palo Alto varO.
Molecular and Biochemical Parasitology, Volume 170, Issue 2, April 2010, Pages 84-92
Am J Trop Med Hyg 2009;81 987-993
We investigated the relationship between rosetting and clinical malaria in 209 Malian children enrolled in a case-control study of severe malaria.