The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 10480 malaria professionals are enjoying the free benefits of MalariaWorld today

Anemia

Open Access | Review: Severe Malarial Anemia: Innate Immunity and Pathogenesis

November 21, 2011 - 14:56 -- Patrick Sampao
Author(s): 
Douglas J. Perkins, Tom Were, Gregory C. Davenport, Prakasha Kempaiah, James B. Hittner, John Michael Ong'echa
Reference: 
Int J Biol Sci 2011; 7:1427-1442

MalariaWorldAn improved understanding of the etiological basis of suppression of erythropoietic responses in children with SMA may offer the much needed therapeutic alternatives for control of this global disease burden.

Refractory Pancytopenia and Megaloblastic Anemia due to Falciparum Malaria

August 2, 2011 - 09:22 -- Kabogo Ndegwa
Author(s): 
Varun Aggarwal, Anu Maheshwari, Bimbadhar Rath, Praveen Kumar, and Srikanta Basu
Reference: 
J Trop Pediatr (2011) 57 (4): 283-285. doi: 10.1093/tropej/fmq090

Anemia is a common complication in malarial infection. Direct destruction and ineffective erythropoesis does not adequately explain the cause of anemia in malaria.

Medical Condition: 

Intermittent Preventive Treatment with Sulfadoxine-Pyrimethamine against Malaria and Anemia in Pregnant Women

July 7, 2011 - 12:26 -- Patrick Sampao
Author(s): 
Nana O. Wilson., Fatou K. Ceesay., Jonathan K. Stiles., et al.
Reference: 
Am J Trop Med Hyg 2011 vol. 85 no. 1 12-21

This study evaluates the effectiveness of IPTp-SP among pregnant women attending the antenatal clinic at Korle-Bu Teaching Hospital in Accra, Ghana.

Medical Condition: 
Medical Treatment: 

Epidemiology of Hookworm Infection in Kintampo North Municipality, Ghana: Patterns of Malaria Coinfection, Anemia, and Albendazole Treatment Failure

May 5, 2011 - 09:19 -- Patrick Sampao
Author(s): 
Debbie Humphries, Emily Mosites, Michael Cappello, et al.
Reference: 
Am J Trop Med Hyg, May 2011; 84: 792 - 800.

These data confirm a high prevalence of low-intensity hookworm infection in central Ghana and its association with poor nutritional status. The high rate of albendazole failure raises concern about emerging resistance.

Country: 
Medical Treatment: 

Inhibition of erythropoiesis in malaria anemia: role of hemozoin and hemozoin-generated 4-hydroxynonenal

November 23, 2010 - 08:11 -- Kabogo Ndegwa
Author(s): 
Oleksii A. Skorokhod, Luisa Caione, Tiziana Marrocco, Giorgia Migliardi, Valentina Barrera, Paolo Arese, Wanda Piacibello, and Evelin Schwarzer
Reference: 
Blood, 18 November 2010, Vol. 116, No. 20, pp. 4328-4337

Severe malaria anemia is characterized by inhibited/altered erythropoiesis and presence of hemozoin-(HZ)-laden bone-marrow macrophages.

Open Access | Clinical Trials and Observations: High mortality from Plasmodium falciparum malaria in children living with sickle cell anemia on the coast of Kenya

September 10, 2010 - 13:29 -- Kabogo Ndegwa
Author(s): 
Charlotte F. McAuley, Clare Webb, Julie Makani, Alexander Macharia, Sophie Uyoga, Daniel H. Opi, Carolyne Ndila, Antony Ngatia, John Anthony G. Scott, Kevin Marsh, and Thomas N. Williams
Reference: 
Blood, 9 September 2010, Vol. 116, No. 10, pp. 1663-1668.

Although malaria is widely considered a major cause of death in young children born with sickle cell anemia (SCA) in sub-Saharan Africa, this is poorly quantified. We attempted to investigate this question through 4 large case-control analyses involving 7164 children living on the coast of Kenya.

Person: 
Country: 

Open Access | Disorders of Iron Metabolism: Increased serum hepcidin and alterations in blood iron parameters associated with asymptomatic P. falciparum and P. vivax malaria

July 1, 2010 - 10:02 -- Kabogo Ndegwa
Author(s): 
Quirijn de Mast, Din Syafruddin, Stephan Keijmel, Teun Olde Riekerink, Oktavian Deky, Puji B. Asih, Dorine W. Swinkels, Andre J. van der Ven
Reference: 
Haematologica, July 2010; 95: 1068 - 1074.

Asymptomatic malarial parasitemia is associated with increased hepcidin concentrations and anemia, in the absence of a manifest acute phase response.

Open Access | Concurrent Helminthic Infection Protects Schoolchildren with Plasmodium vivax from Anemia

June 25, 2010 - 09:07 -- Kabogo Ndegwa
Author(s): 
Gisely Cardoso Melo, Roberto Carlos Reyes-Lecca, Sheila Vitor-Silva, Wuelton Marcelo Monteiro, Marilaine Martins, Silvana Gomes Benzecry, Maria das Graças Costa Alecrim, Marcus Vinícius Guimarães Lacerda
Reference: 
PLoS ONE 5(6): e11206

For the first time, a cohort study showed that intestinal helminthes protect against hemoglobin decrease during an acute malarial attack by P. vivax.

Country: 

Red Cells, Iron, and Erythropoiesis: Differing effects of HbS and HbC traits on uncomplicated falciparum malaria, anemia, and child growth

June 7, 2010 - 08:47 -- Patrick Sampao
Author(s): 
Benno K., Christina K., et al.
Reference: 
Blood, Jun 2010; 115: 4551 - 4558.

Infants with HbAS were protected from uncomplicated malaria (P < .005) and anemia (P < .001), had lower age-adjusted parasite densities (P < .001), and higher age-adjusted hemoglobin levels compared with children with the HbAA genotype (P = .004).

Person: 
Country: 

Open Access | Chloroquine and Its Derivatives Exacerbate B19V-Associated Anemia by Promoting Viral Replication

April 29, 2010 - 13:21 -- Kabogo Ndegwa
Author(s): 
Claudia Bönsch, Christoph Kempf, Ivo Mueller, Laurens Manning, Moses Laman, Timothy M. E. Davis, Carlos Ros
Reference: 
PLoS Negl Trop Dis 4(4): e669

Our data strongly suggest that 4-aminoquinoline drugs and their metabolites exacerbate B19V-associated anemia by promoting B19V replication. Consideration should be given for choosing a non-4-aminoquinoline drug to partner artemisinin compounds in combination antimalarial therapy.

Medical Condition: 

Pages

Subscribe to RSS - Anemia