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Plasmodium chabaudi

Open Access | Distinct Kinetics of Memory B-Cell and Plasma-Cell Responses in Peripheral Blood Following a Blood-Stage Plasmodium chabaudi Infection in Mice

November 30, 2010 - 11:34 -- Kabogo Ndegwa
Author(s): 
Eunice W. Nduati, Dorothy H. L. Ng, Francis M. Ndungu, Peter Gardner, Britta C. Urban, Jean Langhorne
Reference: 
PLoS ONE 5(11): e15007

B cell and plasma cell responses take place in lymphoid organs, but because of the inaccessibility of these organs, analyses of human responses are largely performed using peripheral blood mononuclear cells (PBMC).

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Open Access | Effector Memory Th1 CD4 T Cells Are Maintained in a Mouse Model of Chronic Malaria

November 26, 2010 - 09:52 -- Kabogo Ndegwa
Author(s): 
Robin Stephens, Jean Langhorne
Reference: 
PLoS Pathog 6(11): e1001208

Protection against malaria often decays in the absence of infection, suggesting that protective immunological memory depends on stimulation.

Testosterone-induced permanent changes of hepatic gene expression in female mice sustained during Plasmodium chabaudi malaria infection

November 24, 2010 - 09:11 -- Patrick Sampao
Author(s): 
Denis Delic, Nicole Gailus, Hans-Werner Vohr, Mohamed Dkhil, Saleh Al-Quraishy and Frank Wunderlich
Reference: 
Journal of Molecular Endocrinology (2010) 45 379-390 

Here, we investigate as to whether this conversion coincides with permanent changes of hepatic gene expression profiles. Female mice aged 10–12 weeks were treated with testosterone for 3 weeks; then, testosterone treatment was discontinued for 12 weeks before challenging with 106 P. chabaudi-infected erythrocytes.

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Fungal and Parasitic Infections: T Cells but Not NK Cells Are Essential for Cell-Mediated Immunity against Plasmodium chabaudi Malaria

September 24, 2010 - 07:05 -- Patrick Sampao
Author(s): 
William P. Weidanz, GayeLyn LaFleur, Andrew Brown, James M. Burns, Jr., Irene Gramaglia, and Henri C. van der Heyde
Reference: 
Infect. Immun., Oct 2010; 78: 4331 - 4340.

Collectively, these data indicate that the suppression of acute P. chabaudi infection by CMI is T cell dependent, is independent of NK cells, and may be attributed to the deficient IFN response seen early in T-cell-depleted mice.

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Induction of an IL7-R+c-Kithi myelolymphoid progenitor critically dependent on IFN-γ signaling during acute malaria

May 19, 2010 - 14:19 -- Patrick Sampao
Author(s): 
Nikolai N B., Douglas E B., et al.
Reference: 
Nature Immunology 11, 477-485 (2 May 2010)

Here we show that after infection of mice with Plasmodium chabaudi, a c-Kithi progenitor subset positive for interleukin 7 receptor-α (IL-7Rα) emerged that had both lymphoid and myeloid potential in vitro.

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Open Access | On the Control of Acute Rodent Malaria Infections by Innate Immunity

May 13, 2010 - 06:35 -- Kabogo Ndegwa
Author(s): 
Beth F. Kochin, Andrew J. Yates, Jacobus C. de Roode, Rustom Antia
Reference: 
PLoS ONE 5(5): e10444

Does specific immunity, innate immunity or resource (red blood cell) limitation control the first peak of the blood-stage parasite in acute rodent malaria infections?

Loss of Ability To Self-Heal Malaria upon Taurine Transporter Deletion

March 21, 2010 - 11:18 -- Ingeborg van Schayk
Author(s): 
Denis Delic, Ulrich Warskulat, Elena Borsch, Saad Al-Qahtani, Saleh Al-Quraishi, Dieter Haussinger, and Frank Wunderlich
Reference: 
Infect. Immun. 2010;78 1642-1649

Deletion of the taurine transporter gene (taut) results in lowered levels of taurine, the most abundant amino acid in mammals. Here, we show that taut–/– mice have lost their ability to self-heal blood-stage infections with Plasmodium chabaudi malaria. 

Immunology: Parasitaemia levels in Plasmodium chabaudi infected-mice modify IFN-gamma and IL-10 expression after a homologous or heterologous challenge

March 11, 2010 - 13:18 -- Patrick Sampao
Author(s): 
M. Aguilar-Medina, R. Ramos-Payan, E. Arambula-Meraz, L. Sanchez-Torres, L. Favila-Castillo.
Reference: 
Parasite Immunology,Volume 32, Issue 4, April 2010, Pages: 267-274

CB6F1 mice infected with the nonlethal Plasmodium chabaudi chabaudi AS suffer parasitaemia levels up to 40% (full parasitaemia, FP) and develop both homologous and heterologous (against the lethal Plasmodium yoelii 17XL) protective immunity.

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Open Access | Functional Memory B Cells and Long-Lived Plasma Cells Are Generated after a Single Plasmodium chabaudi Infection in Mice

December 23, 2009 - 09:21 -- Ingeborg van Schayk
Author(s): 
Ndungu FM, Cadman ET, Coulcher J, Nduati E, Couper E, et al.
Reference: 
PLoS Pathog 5(12): e1000690

The cellular mechanisms underlying B cell and antibody responses are difficult to study in human infections; therefore, we have investigated the kinetics, duration and characteristics of the Plasmodium-specific memory B cell response in an infection of P. chabaudi in mice.

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Short communication: Investigation of memory responses following Plasmodium chabaudi AS infection in mice distinct in susceptibility to clinical malaria

December 16, 2009 - 10:44 -- Ingeborg van Schayk
Author(s): 
Jiraprapa Wipasa, Panida Hemsokana, Tunlaya Ruankham & Surat Hongsibsong
Reference: 
Parasitology Research, Volume 106, Number 1 / December, 2009 : 283-287

This study aimed to investigate the development of memory responses in susceptible A/J and resistant C57BL/6 mice which differ in the degree of susceptibility to clinical malaria following P. chabaudi AS infection.

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