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Plasmodium chabaudi

Plasmodium chabaudi AS induces pregnancy loss in association with systemic pro-inflammatory immune responses in A/J and C57BL/6 mice

March 8, 2012 - 06:57 -- Kabogo Ndegwa
Author(s): 
D. Sarr, G. M. Smith, J. S. Poovassery, T. Nagy, J. M. Moore
Reference: 
Parasite Immunology, Volume 34, Issue 4, pages 224–235, April 2012

MalariaWorldThe molecular mechanisms that underlie poor birth outcomes in malaria during pregnancy remain poorly defined.

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The contribution of Plasmodium chabaudi to our understanding of malaria

January 30, 2012 - 14:56 -- Patrick Sampao
Author(s): 
Robin Stephens, Richard L. Culleton, Tracey J. Lamb
Reference: 
Trends in Parasitology, Volume 28, Issue 2, February 2012, Pages 73-82

MalariaWorldWe outline here the parallels between the Plasmodium chabaudi mouse model of malaria and human malaria.

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High-throughput multi-parameter flow-cytometric analysis from micro-quantities of Plasmodium-infected blood

November 16, 2011 - 09:03 -- Patrick Sampao
Author(s): 
Simon H. Apte, Penny L. Groves, Joanne S. Roddick, Vanusa P. da Hora, Denise L. Doolan
Reference: 
International Journal for Parasitology, Volume 41, Issue 12, October 2011, Pages 1285-1294

MalariaWorldHerein, we describe the technique and demonstrate its application in vaccinology and with a range of rodent and human parasite species including Plasmodium yoelii, Plasmodium chabaudi, Plasmodium berghei and Plasmodium falciparum.

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Open Access | Characterization and tissue-specific expression patterns of the Plasmodium chabaudi cir multigene family

September 28, 2011 - 08:04 -- Kabogo Ndegwa
Author(s): 
Petra Ebbinghaus, Jurgen Krucken
Reference: 
Malaria Journal 2011, 10:272 (19 September 2011)

The tissue-specific expression of cir mRNAs found in this study indicates correlation between expression of CIR antigens and distribution of parasites in inner organs.

Signalling through the IL-2 receptor [gamma]c peptide (CD132) is essential for the expression of immunity to Plasmodium chabaudi adami blood-stage malaria (pages 512–516)

August 16, 2011 - 12:57 -- Kabogo Ndegwa
Author(s): 
W. P. Weidanz, G. LaFleur, A. Kita-Yarbro, K. Nelson, J. M. Burns JR
Reference: 
Parasite Immunology, Volume 33, Issue 9, pages 512–516, September 2011

A genetic dissection approach was employed to determine whether the IL-2 receptor complex (IL-2R) comprised of α, β and γ chains is required for the suppression of Plasmodium chabaudi adami parasitemia.

Opioid δ1 receptor antagonist 7-benzylidenenaltrexone as an effective resistance reverser for chloroquine-resistant Plasmodium chabaudi

July 28, 2011 - 07:38 -- Kabogo Ndegwa
Author(s): 
Yoshinori Miyata, Hideaki Fujii, Yumiko Osa, Seiki Kobayashi, Tsutomu Takeuchi, Hiroshi Nagase
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 21, Issue 16, 15 August 2011, Pages 4710-4712

We evaluated antimalarial and/or chloroquine-resistance reversing effects of five opioid receptor antagonists.

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Hepatic miRNA expression reprogrammed by Plasmodium chabaudi malaria

April 20, 2011 - 07:46 -- Kabogo Ndegwa
Author(s): 
Denis Delić, Mohamed Dkhil, Saleh Al-Quraishy & Frank Wunderlich
Reference: 
Parasitology Research, Volume 108, Number 5, 1111-1121

Evidence is accumulating that miRNAs are critically implicated in the outcome of diseases, but little information is available for infectious diseases.

IL-2 Contributes to Maintaining a Balance between CD4+Foxp3+ Regulatory T Cells and Effector CD4+ T Cells Required for Immune Control of Blood-Stage Malaria Infection

April 7, 2011 - 07:26 -- Kabogo Ndegwa
Author(s): 
Floriana Berretta, Jessica St-Pierre, Ciriaco A. Piccirillo, and Mary M. Stevenson
Reference: 
The Journal of Immunology April 15, 2011 vol. 186 no. 8 4862-4871

To investigate the role of CD4+CD25+Foxp3+ regulatory T (Treg) cells in blood-stage malaria, we compared Plasmodium chabaudi AS infection in wild-type (WT) C57BL/6 and transgenic mice overexpressing the transcription factor Foxp3 (Foxp3Tg) and observed that Foxp3Tg mice experienced lethal infection and deficient malaria-specific immune responses.

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Transformation of the rodent malaria parasite Plasmodium chabaudi

April 4, 2011 - 12:25 -- Kabogo Ndegwa
Author(s): 
Philip J Spence, Deirdre Cunningham, William Jarra, Jennifer Lawton, Jean Langhorne, Joanne Thompson
Reference: 
Nature Protocols 6, 553–561 (2011)

The rodent malaria parasite Plasmodium chabaudi chabaudi shares many features with human malaria species, including P. falciparum, and is the in vivo model of choice for many aspects of malaria research in the mammalian host, from sequestration of parasitized erythrocytes, to antigenic variation and host immunity and immunopathology.

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Strain-specific immunity induced by immunization with pre-erythrocytic stages of Plasmodium chabaudi (pages 73–78)

December 16, 2010 - 08:54 -- Kabogo Ndegwa
Author(s): 
R. L. Culleton, M. Inoue, S. E. Reece, S. Cheesman, R. Carter
Reference: 
Parasite Immunology, Volume 33, Issue 1, pages 73–78, January 2011

One of the most promising approaches in the efforts to produce a malaria vaccine involves the use of attenuated whole sporozoite immunizations.

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