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Plasmodium chabaudi

Virulence, drug sensitivity and transmission success in the rodent malaria Plasmodium chabaudi.

October 4, 2012 - 16:39 -- Patrick Sampao
Author(s): 
Schneider P, Bell AS, Sim DG, O'Donnell AJ, Blanford S, Paaijmans KP, Read AF, Reece SE.
Reference: 
Proc Biol Sci. 2012 Sep 26.

MalariaWorldHere, we test the hypothesis that virulent malaria parasites are less susceptible to drug treatment than less virulent parasites.

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NOT Open Access | Organ-specific testosterone-insensitive response of miRNA expression of C57BL/6 mice to Plasmodium chabaudi malaria

September 3, 2012 - 08:05 -- Kabogo Ndegwa
Author(s): 
Saleh Al-Quraishy, Mohamed A. Dkhil, Denis Delic, Abdel Azeem Abdel-Baki & Frank Wunderlich
Reference: 
Parasitology Research, Volume 111, Number 3 (2012), 1093-1101

MalariaWorldIncreasing evidence critically implicates miRNAs in the pathogenesis of diseases, but little is known in context with infectious diseases.

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The Evolutionary Consequences of Blood-Stage Vaccination on the Rodent Malaria Plasmodium chabaudi

August 2, 2012 - 09:14 -- Kabogo Ndegwa
Author(s): 
Victoria C. Barclay, Derek Sim, Brian H. K. Chan, Lucas A. Nell, Maia A. Rabaa, Andrew S. Bell, Robin F. Anders, Andrew F. Read
Reference: 
PLos Biol 10(7): e1001368

MalariaWorldMalaria vaccine developers are concerned that antigenic escape will erode vaccine efficacy.

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NOT Open Access | Investigation of 7-benzylidenenaltrexone derivatives as resistance reverser for chloroquine-resistant Plasmodium chabaudi

July 31, 2012 - 07:10 -- Kabogo Ndegwa
Author(s): 
Yoshinori Miyata, Hideaki Fujii, Yuka Uenohara, Seiki Kobayashi, Tsutomu Takeuchi, Hiroshi Nagase
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 22, Issue 16, 15 August 2012, Pages 5174–5176

MalariaWorldDerivatives of 7-benzylidenenaltrexone (BNTX), which was recently reported to be an effective chloroquine (CQ)-resistance reverser, were synthesized and evaluated for their CQ-resistance reversing activities.

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NOT Open Access | Endogenous galectin-3 controls experimental malaria in a species-specific manner

June 14, 2012 - 07:28 -- Kabogo Ndegwa
Author(s): 
M. A. Toscano, J. E. Tongren, J. B. De Souza, F.-T. Liu, E. M. Riley and G. A. Rabinovich
Reference: 
Parasite Immunology, Volume 34, Issue 7, pages 383–387, July 2012

MalariaWorldGalectins are evolutionarily conserved glycan-binding proteins with pleiotropic roles in innate and adaptive immune responses.

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Improved methods for haemozoin quantification in tissues yield organ- and parasite-specific information in malaria infected mice

May 16, 2012 - 07:01 -- Kabogo Ndegwa
Author(s): 
Deroost K, Lays N, Noppen S, Martens E, Opdenakker G, Van den Steen PE
Reference: 
Malaria Journal 2012, 11:166 (14 May 2012)

MalariaWorldThe developed techniques were useful to quantify Hz in different organs with a high reproducibility and sensitivity.

Restricted | Recombinant Viral-Vectored Vaccines Expressing Plasmodium chabaudi AS Apical Membrane Antigen 1: Mechanisms of Vaccine-Induced Blood-Stage Protection

May 8, 2012 - 13:36 -- Kabogo Ndegwa
Author(s): 
Sumi Biswas, Alexandra J. Spencer, Emily K. Forbes, Sarah C. Gilbert, Anthony A. Holder, Adrian V. S. Hill, and Simon J. Draper
Reference: 
The Journal of Immunology May 15, 2012 vol. 188 no. 10 5041-5053

MalariaWorldApical membrane Ag 1 (AMA1) is one of the leading candidate Ags for inclusion in a subunit vaccine against blood-stage malaria.

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Direct loop-mediated isothermal amplification from Plasmodium chabaudi infected blood samples: Inability to discriminate genomic and cDNA sequences

May 2, 2012 - 08:52 -- Kabogo Ndegwa
Author(s): 
Petra Ebbinghaus, Georg von Samson-Himmelstjerna, Jürgen Krücken
Reference: 
Experimental Parasitology, Volume 131, Issue 1, May 2012, Pages 40–44

MalariaWorldLoop-mediated isothermal amplification (LAMP) has been increasingly used for diagnosis and quantification of pathogens.

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Open Access | Characterization and gene expression analysis of the cir multi-gene family of Plasmodium chabaudi chabaudi (AS)

April 2, 2012 - 14:20 -- Patrick Sampao
Author(s): 
Lawton J, Brugat T, Yam X, Reid AJ, Boehme U, Otto TD, Pain A, Jackson A, Berriman M, Cunningham D, Preiser P, Langhorne J
Reference: 
BMC Genomics 2012, 13:125 (29 March 2012)

MalariaWorldIn this model, pir genes are called cirs and may be involved in this mechanism, allowing evasion of host immune responses. In order to fully understand the role(s) of CIR proteins during P. chabaudi infection, a detailed characterization of the cir gene family was required.

Plasmodium chabaudi AS induces pregnancy loss in association with systemic pro-inflammatory immune responses in A/J and C57BL/6 mice

March 8, 2012 - 06:57 -- Kabogo Ndegwa
Author(s): 
D. Sarr, G. M. Smith, J. S. Poovassery, T. Nagy, J. M. Moore
Reference: 
Parasite Immunology, Volume 34, Issue 4, pages 224–235, April 2012

MalariaWorldThe molecular mechanisms that underlie poor birth outcomes in malaria during pregnancy remain poorly defined.

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