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artemether resistance

Open Access | Artemether resistance in vitro is linked to mutations in PfATP6 that also interact with mutations in PfMDR1 in travellers returning with Plasmodium falciparum infections

May 2, 2012 - 14:27 -- Kabogo Ndegwa
Author(s): 
Pillai DR, Lau R, Khairnar K, Lepore R, Via A, Staines HM, Krishna S
Reference: 
Malaria Journal 2012, 11:131 (27 April 2012)

MalariaWorldThese findings were further explored in molecular modelling experiments that suggest mutations in pfatp6 are unlikely to affect differential binding of artemisinins at their proposed site, whereas there may be differences in such binding associated with mutations in pfmdr1.

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